Registration of 3D+t coronary CTA and monoplane 2D+t X-ray angiography

Coert T. Metz, Michiel Schaap, Stefan Klein, Nora Baka, Lisan A. Neefjes, Carl Schultz, Wiro J. Niessen, Theo Van Walsum

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


A method for registering preoperative 3D+t coronary CTA with intraoperative monoplane 2D+t X-ray angiography images is proposed to improve image guidance during minimally invasive coronary interventions. The method uses a patient-specific dynamic coronary model, which is derived from the CTA scan by centerline extraction and motion estimation. The dynamic coronary model is registered with the 2D+t X-ray sequence, considering multiple X-ray time points concurrently, while taking breathing induced motion into account. Evaluation was performed on 26 datasets of 17 patients by comparing projected model centerlines with manually annotated centerlines in the X-ray images. The proposed 3D+t/2D+t registration method performed better than a 3D/2D registration method with respect to the accuracy and especially the robustness of the registration. Registration with a median error of 1.47 mm was achieved.

Original languageEnglish
Article number6451286
Pages (from-to)919-931
Number of pages13
JournalIEEE Transactions on Medical Imaging
Issue number5
Publication statusPublished - 20 May 2013
Externally publishedYes


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