TY - JOUR
T1 - Regional and ethnic differences among patients with heart failure in Asia
T2 - The Asian sudden cardiac death in heart failure registry
AU - Lam, Carolyn S P
AU - Teng, Katherine
AU - Tay, Wan Ting
AU - Anand, Inder
AU - Zhang, Shu Dong
AU - Shimizu, Wataru
AU - Narasimhan, Calambur
AU - Park, Sang Weon
AU - Yu, Cheuk Man
AU - Ngarmukos, Tachapong
AU - Omar, Razali
AU - Reyes, Eugene B.
AU - Siswanto, Ambang B.
AU - Hung, Chung Lieh
AU - Ling, Lieng H.
AU - Yap, Jonathan
AU - MacDonald, Michael
AU - Richards, A. Mark
PY - 2016/11/1
Y1 - 2016/11/1
N2 - Aims To characterize regional and ethnic differences in heart failure (HF) across Asia. Methods and results We prospectively studied 5276 patients with stable HF and reduced ejection fraction (≤40%) from 11 Asian regions (China, Hong Kong, India, Indonesia, Japan, Korea, Malaysia, Philippines, Singapore, Taiwan, and Thailand). Mean age was 59.6+13.1 years, 78.2% were men, and mean body mass index was 24.9+5.1 kg/m2. Majority (64%) of patients had two or more comorbid conditions such as hypertension (51.9%), coronary artery disease (CAD, 50.2%), or diabetes (40.4%). The prevalence of CAD was highest in Southeast Asians (58.8 vs. 38.2% in Northeast Asians). Compared with Chinese ethnicity, Malays (adjusted odds ratio [OR] 1.97, 95% CI 1.63-2.38) and Indians (OR 1.44, 95% CI 1.24-1.68) had higher odds of CAD, whereas Koreans (OR 0.38, 95% CI 0.29-0.50) and Japanese (OR 0.44, 95% CI 0.36-0.55) had lower odds. The prevalence of hypertension and diabetes was highest in Southeast Asians (64.2 and 49.3%, respectively) and high-income regions (59.7 and 46.2%, respectively). There was significant interaction between ethnicity and region, where the adjusted odds were 3.95 (95% CI 2.51-6.21) for hypertension and 4.91 (95% CI 3.07-7.87) for diabetes among Indians from high- vs. low-income regions; and 2.60 (95% CI 1.66-4.06) for hypertension and 2.62 (95% CI 1.73-3.97) for diabetes among Malays from high- vs. low-income regions. Conclusions These first prospective multi-national data from Asia highlight the significant heterogeneity among Asian patients with stable HF, and the important influence of both ethnicity and regional income level on patient characteristics. ClinicalTrials.gov identifier NCT01633398.
AB - Aims To characterize regional and ethnic differences in heart failure (HF) across Asia. Methods and results We prospectively studied 5276 patients with stable HF and reduced ejection fraction (≤40%) from 11 Asian regions (China, Hong Kong, India, Indonesia, Japan, Korea, Malaysia, Philippines, Singapore, Taiwan, and Thailand). Mean age was 59.6+13.1 years, 78.2% were men, and mean body mass index was 24.9+5.1 kg/m2. Majority (64%) of patients had two or more comorbid conditions such as hypertension (51.9%), coronary artery disease (CAD, 50.2%), or diabetes (40.4%). The prevalence of CAD was highest in Southeast Asians (58.8 vs. 38.2% in Northeast Asians). Compared with Chinese ethnicity, Malays (adjusted odds ratio [OR] 1.97, 95% CI 1.63-2.38) and Indians (OR 1.44, 95% CI 1.24-1.68) had higher odds of CAD, whereas Koreans (OR 0.38, 95% CI 0.29-0.50) and Japanese (OR 0.44, 95% CI 0.36-0.55) had lower odds. The prevalence of hypertension and diabetes was highest in Southeast Asians (64.2 and 49.3%, respectively) and high-income regions (59.7 and 46.2%, respectively). There was significant interaction between ethnicity and region, where the adjusted odds were 3.95 (95% CI 2.51-6.21) for hypertension and 4.91 (95% CI 3.07-7.87) for diabetes among Indians from high- vs. low-income regions; and 2.60 (95% CI 1.66-4.06) for hypertension and 2.62 (95% CI 1.73-3.97) for diabetes among Malays from high- vs. low-income regions. Conclusions These first prospective multi-national data from Asia highlight the significant heterogeneity among Asian patients with stable HF, and the important influence of both ethnicity and regional income level on patient characteristics. ClinicalTrials.gov identifier NCT01633398.
KW - Asia
KW - Epidemiology
KW - Ethnicity
KW - Heart failure
KW - Risk factors
UR - http://www.scopus.com/inward/record.url?scp=85015743050&partnerID=8YFLogxK
U2 - 10.1093/eurheartj/ehw331
DO - 10.1093/eurheartj/ehw331
M3 - Article
C2 - 27502121
AN - SCOPUS:85015743050
SN - 0195-668X
VL - 37
SP - 3141
EP - 3153
JO - European Heart Journal
JF - European Heart Journal
IS - 41
ER -