Refractory Fetal Supraventricular Tachycardia and Obstetric Cholestasis

Jan Dickinson, A.W. Shand, L. D'Orsogna

Research output: Contribution to journalReview article

12 Citations (Scopus)


Objective: Supraventricular tachycardia (SVT) is the most common form of sustained fetal tachyarrhythmia in pregnancy. The development of hydrops with SVT is associated with significant worsening of prognosis. Case: We report a case of fetal SVT with hydrops at 28 weeks' gestation that required both transplacental and direct fetal treatment in a woman with concurrent obstetric cholestasis. Antiarrhythmic therapy and control of the maternal liver function and bile acid levels with ursodeoxycholic acid was associated with a fetal response to treatment resulting in a healthy term live birth. Conclusion: Fetal SVT and hydrops fetalis are associated with significant perinatal morbidity and mortality. Resistance to intensive antiarrhythmic therapies may be augmented by the myocardial effects of obstetric cholestasis and remains a challenge for management. Copyright (C) 2008 S. Karger AG, Basel.
Original languageEnglish
Pages (from-to)277-281
JournalFetal Diagnosis and Therapy
Publication statusPublished - 2008

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