Refining the Risk Stratification in Patients with Acute Coronary Syndrome: Investigating the Potential Role of Optical Coherence Tomography

Kamran Majeed

doi:10.26182/vytq-pt58

Refining the Risk Stratification in Patients with Acute Coronary Syndrome: Investigating the Potential Role of Optical Coherence Tomography

Kamran Majeed

UWA Medical School

Research output: Thesis › Doctoral Thesis

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Abstract

Patients presenting with acute coronary syndrome (ACS) carry a significant risk of future major adverse cardiovascular events (MACE), despite the use of existing risk stratification tools and advancement in available therapies. This has led to the need for improvement in the existing risk stratification tools.
Optical coherence tomography (OCT) is a light based, intravascular imaging modality with the ability to characterise atherosclerotic plaque with a high resolution that approaches to that of histology. Existing data suggests that presence of high risk plaque features potentially provides prognostic information in patients with ACS. This doctoral thesis focuses on refining the methodology of plaque analysis and evaluating the potential role of OCT in risk stratification of patients with ACS.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Schultz, Carl, Supervisor Mori, Trevor, Supervisor Hillis, Graham, Supervisor
Award date	27 Apr 2021
DOIs	https://doi.org/10.26182/vytq-pt58
Publication status	Unpublished - 2021

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10.26182/vytq-pt58

THESIS - DOCTOR OF PHILOSOPHY - MAJEED, Kamran - 2021
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Cite this

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title = "Refining the Risk Stratification in Patients with Acute Coronary Syndrome: Investigating the Potential Role of Optical Coherence Tomography",

abstract = "Patients presenting with acute coronary syndrome (ACS) carry a significant risk of future major adverse cardiovascular events (MACE), despite the use of existing risk stratification tools and advancement in available therapies. This has led to the need for improvement in the existing risk stratification tools. Optical coherence tomography (OCT) is a light based, intravascular imaging modality with the ability to characterise atherosclerotic plaque with a high resolution that approaches to that of histology. Existing data suggests that presence of high risk plaque features potentially provides prognostic information in patients with ACS. This doctoral thesis focuses on refining the methodology of plaque analysis and evaluating the potential role of OCT in risk stratification of patients with ACS. ",

keywords = "Acute coronary syndrome, Percutaneous Coronary Intervention, Optical coherence tomography, plaque behind struts, Vulnerable plaque, risk stratification",

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AB - Patients presenting with acute coronary syndrome (ACS) carry a significant risk of future major adverse cardiovascular events (MACE), despite the use of existing risk stratification tools and advancement in available therapies. This has led to the need for improvement in the existing risk stratification tools. Optical coherence tomography (OCT) is a light based, intravascular imaging modality with the ability to characterise atherosclerotic plaque with a high resolution that approaches to that of histology. Existing data suggests that presence of high risk plaque features potentially provides prognostic information in patients with ACS. This doctoral thesis focuses on refining the methodology of plaque analysis and evaluating the potential role of OCT in risk stratification of patients with ACS.

KW - Acute coronary syndrome

KW - Percutaneous Coronary Intervention

KW - Optical coherence tomography

KW - plaque behind struts

KW - Vulnerable plaque

KW - risk stratification

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M3 - Doctoral Thesis

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Refining the Risk Stratification in Patients with Acute Coronary Syndrome: Investigating the Potential Role of Optical Coherence Tomography

Abstract

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