TY - JOUR
T1 - Refined phenotyping identifies links between preeclampsia and related diseases in a Norwegian preeclampsia family cohort
AU - Thomsen, L.C.V.
AU - Melton, Phillip
AU - Tollaksen, K.
AU - Lyslo, I.
AU - Roten, L.T.
AU - Odland, M.L.
AU - Strand, K.M.
AU - Nygard, O.
AU - Sun, C.
AU - Iversen, A.C.
AU - Austgulen, R.
AU - Moses, Eric
AU - Bjørge, L.
PY - 2015
Y1 - 2015
N2 - © 2015 Wolters Kluwer Health, Inc. All rights reserved. Objective: Preeclampsia is a complex genetic disease of pregnancy with a heterogenous presentation, unknown cause and potential severe outcomes for both mother and child. Preeclamptic women have increased risk for atherothrombotic cardiovascular disease. We aimed to identify heritabilities and phenotypic correlations of preeclampsia and related conditions in the Norwegian Preeclampsia Family Biobank. Methods: By applying a variance components model, a total of 493 individuals (from 138 families with increased occurrence of preeclampsia) were classified according to 30 disease-related phenotypes. Results: Of parous women, 75.7% (263/338) had experienced preeclampsia and 35.7% of women with and 22.4% without preeclampsia delivered children small for gestational age (SGA). We identified 11 phenotypes as heritable. The increased occurrence of preeclampsia was reflected by the presence [heritability (H2r)=0.60)] and severity (H2r=0.15) of preeclampsia and being born in a preeclamptic pregnancy (H2r=0.25). Other heritable phenotypes identified included SGA (H2r=0.40), chronic hypertension (H2r=0.57), severity of atherothrombotic cardiovascular disease (H2r=0.31), BMI (H2r=0.60) and pulmonary disease (H2r=0.91). The heritable phenotype preeclampsia overlapped with SGA (P=0.03), whereas pulmonary disease was phenotypically correlated with atherothrombotic cardiovascular disease (P
AB - © 2015 Wolters Kluwer Health, Inc. All rights reserved. Objective: Preeclampsia is a complex genetic disease of pregnancy with a heterogenous presentation, unknown cause and potential severe outcomes for both mother and child. Preeclamptic women have increased risk for atherothrombotic cardiovascular disease. We aimed to identify heritabilities and phenotypic correlations of preeclampsia and related conditions in the Norwegian Preeclampsia Family Biobank. Methods: By applying a variance components model, a total of 493 individuals (from 138 families with increased occurrence of preeclampsia) were classified according to 30 disease-related phenotypes. Results: Of parous women, 75.7% (263/338) had experienced preeclampsia and 35.7% of women with and 22.4% without preeclampsia delivered children small for gestational age (SGA). We identified 11 phenotypes as heritable. The increased occurrence of preeclampsia was reflected by the presence [heritability (H2r)=0.60)] and severity (H2r=0.15) of preeclampsia and being born in a preeclamptic pregnancy (H2r=0.25). Other heritable phenotypes identified included SGA (H2r=0.40), chronic hypertension (H2r=0.57), severity of atherothrombotic cardiovascular disease (H2r=0.31), BMI (H2r=0.60) and pulmonary disease (H2r=0.91). The heritable phenotype preeclampsia overlapped with SGA (P=0.03), whereas pulmonary disease was phenotypically correlated with atherothrombotic cardiovascular disease (P
U2 - 10.1097/HJH.0000000000000696
DO - 10.1097/HJH.0000000000000696
M3 - Article
C2 - 26259119
SN - 0263-6352
VL - 33
SP - 2294
EP - 2302
JO - Journal of Hypertension
JF - Journal of Hypertension
IS - 11
ER -
