Reduced risk of plasmodium vivax malaria in Papua New Guinean children with South East Asian Ovalocytosis in two cohorts and a case-control study

A. Rosanas-Urgell; E. Lin; Laurens Manning; P. Rarau; Moses Laman; N. Senn; B. Grimberg; L. Tavul; D. Stanisic; L. Robinson; J. Aponte; E. Dabod; J.C. Reeder; P. Siba; P.A. Zimmerman; Timothy Davis; C.L. King; P. Michon; I. Mueller

doi:10.1371/journal.pmed.1001305

Reduced risk of plasmodium vivax malaria in Papua New Guinean children with South East Asian Ovalocytosis in two cohorts and a case-control study

A. Rosanas-Urgell
, E. Lin
, Laurens Manning
, P. Rarau
, Moses Laman
, N. Senn
, B. Grimberg
, L. Tavul
, D. Stanisic
, L. Robinson
, J. Aponte
, E. Dabod
, J.C. Reeder
, P. Siba
, P.A. Zimmerman
, Timothy Davis
, C.L. King
, P. Michon
, I. Mueller

Research output: Contribution to journal › Article › peer-review

53 Citations (Scopus)

Abstract

[Truncated abstract] Background: The erythrocyte polymorphism, Southeast Asian ovalocytosis (SAO) (which results from a 27-base pair deletion in the erythrocyte band 3 gene, SLC4A1Δ27) protects against cerebral malaria caused by Plasmodium falciparum; however, it is unknown whether this polymorphism also protects against P. vivax infection and disease.Methods and Findings: The association between SAO and P. vivax infection was examined through genotyping of 1,975 children enrolled in three independent epidemiological studies conducted in the Madang area of Papua New Guinea. SAO was associated with a statistically significant 46% reduction in the incidence of clinical P. vivax episodes (adjusted incidence rate ratio [IRR] = 0.54, 95% CI 0.40–0.72, p

Original language	English
Pages (from-to)	1-11
Journal	PLoS Medicine
Volume	9
Issue number	9
DOIs	https://doi.org/10.1371/journal.pmed.1001305
Publication status	Published - 4 Sept 2012

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1371/journal.pmed.1001305Licence: CC BY

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Rosanas-Urgell, A., Lin, E., Manning, L., Rarau, P., Laman, M., Senn, N., Grimberg, B., Tavul, L., Stanisic, D., Robinson, L., Aponte, J., Dabod, E., Reeder, J. C., Siba, P., Zimmerman, P. A., Davis, T., King, C. L., Michon, P., & Mueller, I. (2012). Reduced risk of plasmodium vivax malaria in Papua New Guinean children with South East Asian Ovalocytosis in two cohorts and a case-control study. PLoS Medicine, 9(9), 1-11. https://doi.org/10.1371/journal.pmed.1001305

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title = "Reduced risk of plasmodium vivax malaria in Papua New Guinean children with South East Asian Ovalocytosis in two cohorts and a case-control study",

abstract = "[Truncated abstract] Background: The erythrocyte polymorphism, Southeast Asian ovalocytosis (SAO) (which results from a 27-base pair deletion in the erythrocyte band 3 gene, SLC4A1Δ27) protects against cerebral malaria caused by Plasmodium falciparum; however, it is unknown whether this polymorphism also protects against P. vivax infection and disease.Methods and Findings: The association between SAO and P. vivax infection was examined through genotyping of 1,975 children enrolled in three independent epidemiological studies conducted in the Madang area of Papua New Guinea. SAO was associated with a statistically significant 46\% reduction in the incidence of clinical P. vivax episodes (adjusted incidence rate ratio [IRR] = 0.54, 95\% CI 0.40–0.72, p",

author = "A. Rosanas-Urgell and E. Lin and Laurens Manning and P. Rarau and Moses Laman and N. Senn and B. Grimberg and L. Tavul and D. Stanisic and L. Robinson and J. Aponte and E. Dabod and J.C. Reeder and P. Siba and P.A. Zimmerman and Timothy Davis and C.L. King and P. Michon and I. Mueller",

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Rosanas-Urgell, A, Lin, E, Manning, L, Rarau, P, Laman, M, Senn, N, Grimberg, B, Tavul, L, Stanisic, D, Robinson, L, Aponte, J, Dabod, E, Reeder, JC, Siba, P, Zimmerman, PA, Davis, T, King, CL, Michon, P & Mueller, I 2012, 'Reduced risk of plasmodium vivax malaria in Papua New Guinean children with South East Asian Ovalocytosis in two cohorts and a case-control study', PLoS Medicine, vol. 9, no. 9, pp. 1-11. https://doi.org/10.1371/journal.pmed.1001305

TY - JOUR

T1 - Reduced risk of plasmodium vivax malaria in Papua New Guinean children with South East Asian Ovalocytosis in two cohorts and a case-control study

AU - Rosanas-Urgell, A.

AU - Lin, E.

AU - Manning, Laurens

AU - Rarau, P.

AU - Laman, Moses

AU - Senn, N.

AU - Grimberg, B.

AU - Tavul, L.

AU - Stanisic, D.

AU - Robinson, L.

AU - Aponte, J.

AU - Dabod, E.

AU - Reeder, J.C.

AU - Siba, P.

AU - Zimmerman, P.A.

AU - Davis, Timothy

AU - King, C.L.

AU - Michon, P.

AU - Mueller, I.

PY - 2012/9/4

Y1 - 2012/9/4

N2 - [Truncated abstract] Background: The erythrocyte polymorphism, Southeast Asian ovalocytosis (SAO) (which results from a 27-base pair deletion in the erythrocyte band 3 gene, SLC4A1Δ27) protects against cerebral malaria caused by Plasmodium falciparum; however, it is unknown whether this polymorphism also protects against P. vivax infection and disease.Methods and Findings: The association between SAO and P. vivax infection was examined through genotyping of 1,975 children enrolled in three independent epidemiological studies conducted in the Madang area of Papua New Guinea. SAO was associated with a statistically significant 46% reduction in the incidence of clinical P. vivax episodes (adjusted incidence rate ratio [IRR] = 0.54, 95% CI 0.40–0.72, p

AB - [Truncated abstract] Background: The erythrocyte polymorphism, Southeast Asian ovalocytosis (SAO) (which results from a 27-base pair deletion in the erythrocyte band 3 gene, SLC4A1Δ27) protects against cerebral malaria caused by Plasmodium falciparum; however, it is unknown whether this polymorphism also protects against P. vivax infection and disease.Methods and Findings: The association between SAO and P. vivax infection was examined through genotyping of 1,975 children enrolled in three independent epidemiological studies conducted in the Madang area of Papua New Guinea. SAO was associated with a statistically significant 46% reduction in the incidence of clinical P. vivax episodes (adjusted incidence rate ratio [IRR] = 0.54, 95% CI 0.40–0.72, p

U2 - 10.1371/journal.pmed.1001305

DO - 10.1371/journal.pmed.1001305

M3 - Article

SN - 1549-1277

VL - 9

SP - 1

EP - 11

JO - PLoS Medicine

JF - PLoS Medicine

IS - 9

ER -

Reduced risk of plasmodium vivax malaria in Papua New Guinean children with South East Asian Ovalocytosis in two cohorts and a case-control study

Abstract

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