Reduced risk of plasmodium vivax malaria in Papua New Guinean children with South East Asian Ovalocytosis in two cohorts and a case-control study

A. Rosanas-Urgell, E. Lin, Laurens Manning, P. Rarau, Moses Laman, N. Senn, B. Grimberg, L. Tavul, D. Stanisic, L. Robinson, J. Aponte, E. Dabod, J.C. Reeder, P. Siba, P.A. Zimmerman, Timothy Davis, C.L. King, P. Michon, I. Mueller

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    43 Citations (Scopus)

    Abstract

    [Truncated abstract] Background: The erythrocyte polymorphism, Southeast Asian ovalocytosis (SAO) (which results from a 27-base pair deletion in the erythrocyte band 3 gene, SLC4A1Δ27) protects against cerebral malaria caused by Plasmodium falciparum; however, it is unknown whether this polymorphism also protects against P. vivax infection and disease.Methods and Findings: The association between SAO and P. vivax infection was examined through genotyping of 1,975 children enrolled in three independent epidemiological studies conducted in the Madang area of Papua New Guinea. SAO was associated with a statistically significant 46% reduction in the incidence of clinical P. vivax episodes (adjusted incidence rate ratio [IRR] = 0.54, 95% CI 0.40–0.72, p
    Original languageEnglish
    Pages (from-to)1-11
    JournalPLoS Medicine
    Volume9
    Issue number9
    DOIs
    Publication statusPublished - 4 Sep 2012

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