Redox proteomics identification of oxidatively modified brain proteins in inherited Alzheimer's disease: An initial assessment

D.A. Butterfield, Anastazija Gnjec, H.F. Poon, A. Castegna, W.M. Pierce, J.B. Klien, Ralph Martins

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    Abstract

    Objective: To identify oxidatively modified proteins in brains of persons with inherited Alzheimer's disease. Methods: Redox proteomics was used to identify oxidatively modified brain proteins in persons with mutations in the genes for presenilin-1 (PS-1). Results: An initial redox proteornics assessment of oxidatively modified proteins from brains of individuals with PS-1 mutations was performed. These PS-1 mutations, Q222H and M233T, are completely penetrant causing early-onset familial AD as, previously reported in these Australian families. We show that oxidative modifications of ubiquitin carboxyl-terminal hydrolase L1 (UCH-LI), gamma-enolase, actin, and dimethylarginine dimethylarninohydrolase 1 (DMDMAH-1) are present in the brain of familial AD subjects. Conclusions: These initial results suggest that oxidatively modified proteins are important common features in both familial and sporadic AD.
    Original languageEnglish
    Pages (from-to)391-397
    JournalJournal of Alzheimer's Disease
    Volume10
    Issue number4
    Publication statusPublished - 2006

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    Butterfield, D. A., Gnjec, A., Poon, H. F., Castegna, A., Pierce, W. M., Klien, J. B., & Martins, R. (2006). Redox proteomics identification of oxidatively modified brain proteins in inherited Alzheimer's disease: An initial assessment. Journal of Alzheimer's Disease, 10(4), 391-397.