Redox poly(ethylene glycol)-b-poly(l-lactide) micelles containing diselenide bonds for effective drug delivery

X. Zeng, X. Zhou, M. Li, C. Wang, Jiake Xu, D. Ma, W. Xue

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

© 2015, Springer Science+Business Media New York. Bioreducible polymers have appeared as the ideal drug carriers for tumor therapy due to their properties of high stability in extracellular circulation and rapid drug release in intracellular reducing environment. Recently, the diselenide bond has emerged as a new reduction-sensitive linkage. In this work, the amphiphilic poly(ethylene glycol)-b-poly(l-lactide) containing diselenide bond has been synthesized and used to load anti-tumor drug, docetaxel (DTX), to form the redox micelles. It was found that the redox micelles showed a rapid response to glutataione (GSH), which resulted in a fast release of DTX in the presence of GSH. In contrast,
Original languageEnglish
Pages (from-to)1-12
JournalJournal of Materials Science: Materials in Medicine
Volume26
Issue number9
DOIs
Publication statusPublished - 2015

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