TY - JOUR
T1 - Redox poly(ethylene glycol)-b-poly(l-lactide) micelles containing diselenide bonds for effective drug delivery
AU - Zeng, X.
AU - Zhou, X.
AU - Li, M.
AU - Wang, C.
AU - Xu, Jiake
AU - Ma, D.
AU - Xue, W.
PY - 2015
Y1 - 2015
N2 - © 2015, Springer Science+Business Media New York. Bioreducible polymers have appeared as the ideal drug carriers for tumor therapy due to their properties of high stability in extracellular circulation and rapid drug release in intracellular reducing environment. Recently, the diselenide bond has emerged as a new reduction-sensitive linkage. In this work, the amphiphilic poly(ethylene glycol)-b-poly(l-lactide) containing diselenide bond has been synthesized and used to load anti-tumor drug, docetaxel (DTX), to form the redox micelles. It was found that the redox micelles showed a rapid response to glutataione (GSH), which resulted in a fast release of DTX in the presence of GSH. In contrast,
AB - © 2015, Springer Science+Business Media New York. Bioreducible polymers have appeared as the ideal drug carriers for tumor therapy due to their properties of high stability in extracellular circulation and rapid drug release in intracellular reducing environment. Recently, the diselenide bond has emerged as a new reduction-sensitive linkage. In this work, the amphiphilic poly(ethylene glycol)-b-poly(l-lactide) containing diselenide bond has been synthesized and used to load anti-tumor drug, docetaxel (DTX), to form the redox micelles. It was found that the redox micelles showed a rapid response to glutataione (GSH), which resulted in a fast release of DTX in the presence of GSH. In contrast,
U2 - 10.1007/s10856-015-5573-5
DO - 10.1007/s10856-015-5573-5
M3 - Article
C2 - 26395359
VL - 26
SP - 1
EP - 12
JO - Journal of Materials in Medicine
JF - Journal of Materials in Medicine
SN - 0957-4530
IS - 9
ER -