Recurrence in patients with stage I colorectal cancer

P.E. Teloken, D. Ransom, I. Faragher, I. Jones, P. Gibbs, Cameron Platell

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

© 2016 Royal Australasian College of Surgeons. Background: Outcomes of patients with stage I colorectal cancer submitted to surgery with curative intent have not been thoroughly explored in contemporary series. Methods: All patients with colon or rectal adenocarcinoma who underwent resection from the St John of God Hospital (1996-2013) and BioGrid (1991-2013) databases were identified. Patients submitted to local excision, polypectomies or neoadjuvant treatment were excluded. Outcomes included recurrence (combined local and systemic), recurrence-free and overall survival, and survival after recurrence. Results: A total of 1193 patients with stage I disease were included. Median age was 67 (interquartile range 59-75) and median follow-up was 3.2 years (interquartile range 1.4-5.8). Five-year recurrence rate was 7.1% (95% confidence interval (CI) 5.4-9.4%; 5.0% for colon and 11.1% for rectal cancer). Rectal location was an independent predictor of recurrence (hazard ratio (HR) 1.97, 95% CI 1.09-3.55; P=0.024). Lymphovascular invasion was an independent predictor of recurrence only in patients with rectal cancer (HR 3.0, 95% CI 1.2-7.6; P=0.018). Five-year recurrence-free survival was 83.2% (95% CI 80.3-85.4%). Age (HR 1.05, 95% CI 1.03-1.07; P
Original languageEnglish
Pages (from-to)49-53
JournalANZ Journal of Surgery
Volume86
Issue number1-2
DOIs
Publication statusPublished - 2016

Fingerprint

Colorectal Neoplasms
Recurrence
Confidence Intervals
Rectal Neoplasms
Survival
Colon
Neoadjuvant Therapy
Adenocarcinoma
Databases

Cite this

Teloken, P. E., Ransom, D., Faragher, I., Jones, I., Gibbs, P., & Platell, C. (2016). Recurrence in patients with stage I colorectal cancer. ANZ Journal of Surgery, 86(1-2), 49-53. https://doi.org/10.1111/ans.13254
Teloken, P.E. ; Ransom, D. ; Faragher, I. ; Jones, I. ; Gibbs, P. ; Platell, Cameron. / Recurrence in patients with stage I colorectal cancer. In: ANZ Journal of Surgery. 2016 ; Vol. 86, No. 1-2. pp. 49-53.
@article{00865d3bd26e4ebfa8e7f7694b7c7e9d,
title = "Recurrence in patients with stage I colorectal cancer",
abstract = "{\circledC} 2016 Royal Australasian College of Surgeons. Background: Outcomes of patients with stage I colorectal cancer submitted to surgery with curative intent have not been thoroughly explored in contemporary series. Methods: All patients with colon or rectal adenocarcinoma who underwent resection from the St John of God Hospital (1996-2013) and BioGrid (1991-2013) databases were identified. Patients submitted to local excision, polypectomies or neoadjuvant treatment were excluded. Outcomes included recurrence (combined local and systemic), recurrence-free and overall survival, and survival after recurrence. Results: A total of 1193 patients with stage I disease were included. Median age was 67 (interquartile range 59-75) and median follow-up was 3.2 years (interquartile range 1.4-5.8). Five-year recurrence rate was 7.1{\%} (95{\%} confidence interval (CI) 5.4-9.4{\%}; 5.0{\%} for colon and 11.1{\%} for rectal cancer). Rectal location was an independent predictor of recurrence (hazard ratio (HR) 1.97, 95{\%} CI 1.09-3.55; P=0.024). Lymphovascular invasion was an independent predictor of recurrence only in patients with rectal cancer (HR 3.0, 95{\%} CI 1.2-7.6; P=0.018). Five-year recurrence-free survival was 83.2{\%} (95{\%} CI 80.3-85.4{\%}). Age (HR 1.05, 95{\%} CI 1.03-1.07; P",
author = "P.E. Teloken and D. Ransom and I. Faragher and I. Jones and P. Gibbs and Cameron Platell",
year = "2016",
doi = "10.1111/ans.13254",
language = "English",
volume = "86",
pages = "49--53",
journal = "Australian New Zealand Journal of Surgery",
issn = "1445-1433",
publisher = "John Wiley & Sons",
number = "1-2",

}

Teloken, PE, Ransom, D, Faragher, I, Jones, I, Gibbs, P & Platell, C 2016, 'Recurrence in patients with stage I colorectal cancer' ANZ Journal of Surgery, vol. 86, no. 1-2, pp. 49-53. https://doi.org/10.1111/ans.13254

Recurrence in patients with stage I colorectal cancer. / Teloken, P.E.; Ransom, D.; Faragher, I.; Jones, I.; Gibbs, P.; Platell, Cameron.

In: ANZ Journal of Surgery, Vol. 86, No. 1-2, 2016, p. 49-53.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Recurrence in patients with stage I colorectal cancer

AU - Teloken, P.E.

AU - Ransom, D.

AU - Faragher, I.

AU - Jones, I.

AU - Gibbs, P.

AU - Platell, Cameron

PY - 2016

Y1 - 2016

N2 - © 2016 Royal Australasian College of Surgeons. Background: Outcomes of patients with stage I colorectal cancer submitted to surgery with curative intent have not been thoroughly explored in contemporary series. Methods: All patients with colon or rectal adenocarcinoma who underwent resection from the St John of God Hospital (1996-2013) and BioGrid (1991-2013) databases were identified. Patients submitted to local excision, polypectomies or neoadjuvant treatment were excluded. Outcomes included recurrence (combined local and systemic), recurrence-free and overall survival, and survival after recurrence. Results: A total of 1193 patients with stage I disease were included. Median age was 67 (interquartile range 59-75) and median follow-up was 3.2 years (interquartile range 1.4-5.8). Five-year recurrence rate was 7.1% (95% confidence interval (CI) 5.4-9.4%; 5.0% for colon and 11.1% for rectal cancer). Rectal location was an independent predictor of recurrence (hazard ratio (HR) 1.97, 95% CI 1.09-3.55; P=0.024). Lymphovascular invasion was an independent predictor of recurrence only in patients with rectal cancer (HR 3.0, 95% CI 1.2-7.6; P=0.018). Five-year recurrence-free survival was 83.2% (95% CI 80.3-85.4%). Age (HR 1.05, 95% CI 1.03-1.07; P

AB - © 2016 Royal Australasian College of Surgeons. Background: Outcomes of patients with stage I colorectal cancer submitted to surgery with curative intent have not been thoroughly explored in contemporary series. Methods: All patients with colon or rectal adenocarcinoma who underwent resection from the St John of God Hospital (1996-2013) and BioGrid (1991-2013) databases were identified. Patients submitted to local excision, polypectomies or neoadjuvant treatment were excluded. Outcomes included recurrence (combined local and systemic), recurrence-free and overall survival, and survival after recurrence. Results: A total of 1193 patients with stage I disease were included. Median age was 67 (interquartile range 59-75) and median follow-up was 3.2 years (interquartile range 1.4-5.8). Five-year recurrence rate was 7.1% (95% confidence interval (CI) 5.4-9.4%; 5.0% for colon and 11.1% for rectal cancer). Rectal location was an independent predictor of recurrence (hazard ratio (HR) 1.97, 95% CI 1.09-3.55; P=0.024). Lymphovascular invasion was an independent predictor of recurrence only in patients with rectal cancer (HR 3.0, 95% CI 1.2-7.6; P=0.018). Five-year recurrence-free survival was 83.2% (95% CI 80.3-85.4%). Age (HR 1.05, 95% CI 1.03-1.07; P

U2 - 10.1111/ans.13254

DO - 10.1111/ans.13254

M3 - Article

VL - 86

SP - 49

EP - 53

JO - Australian New Zealand Journal of Surgery

JF - Australian New Zealand Journal of Surgery

SN - 1445-1433

IS - 1-2

ER -