TY - JOUR
T1 - Recovery of CD4+ T cells in HIV patients with a stable virologic response to antiretroviral therapy is associated with polymorphisms of interleukin-6 and central major histocompatibility complex genes
AU - Fernandez, Sonia
AU - Rosenow, A.A.
AU - James, I.R.
AU - Roberts, S.G.
AU - Nolan, R.C.
AU - French, Martyn
AU - Price, Patricia
PY - 2006
Y1 - 2006
N2 - We investigated whether polymorphisms in genes associated with HIV disease progression and/or immune activation affect CD4(+) T-cell recovery in HIV patients who began combination anti-retroviral therapy (ART) with advanced immunodeficiency and achieved stable control of plasma viremia. Patients with CD4(+) T-cell Counts < 300 cells/mu L (n = 33) and > 400 cells/mu L (n = 37) oil ART were compared. A multiple case-control logistic regression associated carriage of BATI (1,2) or interleukin (IL)6-174(2,2) with low CD4(+) T-cell Counts (P = 0.012). BATI*2 uniquely marks the central major histocompatibility complex region of a conserved haplotype (HLA-A1,B8,BAT1*2,TNFA-308*2,DR3,DQ2). There was no association between alleles carried at CCR5 Delta 32, CCR5 59029, CCR5 59353, CCR2+190 (V641), SDFI 3'UTR, ILIA+4845, ILIB+3953, IL-4589, IL10-592, IL10-RI+536, IL10-RI+1112 IL12B 3'UTR, TNFA-308, or TNFA-1031 and CD4(+) T-cell Counts. We Suggest that immune activation and/or CD4(+) T-cell apoptosis in HIV patients oil effective ART is influenced by genetic factors.
AB - We investigated whether polymorphisms in genes associated with HIV disease progression and/or immune activation affect CD4(+) T-cell recovery in HIV patients who began combination anti-retroviral therapy (ART) with advanced immunodeficiency and achieved stable control of plasma viremia. Patients with CD4(+) T-cell Counts < 300 cells/mu L (n = 33) and > 400 cells/mu L (n = 37) oil ART were compared. A multiple case-control logistic regression associated carriage of BATI (1,2) or interleukin (IL)6-174(2,2) with low CD4(+) T-cell Counts (P = 0.012). BATI*2 uniquely marks the central major histocompatibility complex region of a conserved haplotype (HLA-A1,B8,BAT1*2,TNFA-308*2,DR3,DQ2). There was no association between alleles carried at CCR5 Delta 32, CCR5 59029, CCR5 59353, CCR2+190 (V641), SDFI 3'UTR, ILIA+4845, ILIB+3953, IL-4589, IL10-592, IL10-RI+536, IL10-RI+1112 IL12B 3'UTR, TNFA-308, or TNFA-1031 and CD4(+) T-cell Counts. We Suggest that immune activation and/or CD4(+) T-cell apoptosis in HIV patients oil effective ART is influenced by genetic factors.
U2 - 10.1097/01.qai.0000188990.57760.e3
DO - 10.1097/01.qai.0000188990.57760.e3
M3 - Article
SN - 1525-4135
VL - 41
SP - 1
EP - 5
JO - JAIDS: Journal of Acquired Immune Deficiency Syndromes
JF - JAIDS: Journal of Acquired Immune Deficiency Syndromes
IS - 1
ER -