Reconstruction of the ocular surface using biomaterial templates

Traian V. Chirila, S. Suzuki, L.W. Hirst, Damien G. Harkin

Research output: Chapter in Book/Conference paperChapter

2 Citations (Scopus)

Abstract

This chapter discusses the effect on vision of a large group of pathological conditions, known as ocular surface disorders (OSDs), and presents the therapeutic strategies to reconstruct the abnormal ocular surface. If left untreated, most of the OSDs will lead to partial or total loss of eyesight, especially when limbal stem cell deficiency is involved. An overview of various treatment strategies is presented, with the emphasis on the development of the ex vivo expansion of corneal limbal epithelial cells (presumed to be progenitor or stem cells) and the creation of transplantable epithelial constructs. The use of naturally derived biomaterials (collagen, fibrin, amnion, etc.) or synthetic polymers (polylactides, thermoresponsive polymers, etc.) as substrata in these constructs is critically analyzed. Emphasis is placed on the templates from silk proteins, which are being developed by the authors.

Original languageEnglish
Title of host publicationBiomaterials and Regenerative Medicine in Ophthalmology
EditorsT V Chirila, D Harkin
PublisherElsevier
Pages179-218
Number of pages40
Volume112
Edition2nd
ISBN (Electronic)9780081001844
ISBN (Print)9780081001479
DOIs
Publication statusPublished - 21 Apr 2016
Externally publishedYes

Publication series

NameWoodhead Publishing Series in Biomaterials

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Cite this

Chirila, T. V., Suzuki, S., Hirst, L. W., & Harkin, D. G. (2016). Reconstruction of the ocular surface using biomaterial templates. In T. V. Chirila, & D. Harkin (Eds.), Biomaterials and Regenerative Medicine in Ophthalmology (2nd ed., Vol. 112, pp. 179-218). (Woodhead Publishing Series in Biomaterials). Elsevier. https://doi.org/10.1016/B978-0-08-100147-9.00008-0