TY - CHAP
T1 - Reconstruction of the ocular surface using biomaterial templates
AU - Chirila, Traian V.
AU - Suzuki, S.
AU - Hirst, L.W.
AU - Harkin, Damien G.
PY - 2016/4/21
Y1 - 2016/4/21
N2 - This chapter discusses the effect on vision of a large group of pathological conditions, known as ocular surface disorders (OSDs), and presents the therapeutic strategies to reconstruct the abnormal ocular surface. If left untreated, most of the OSDs will lead to partial or total loss of eyesight, especially when limbal stem cell deficiency is involved. An overview of various treatment strategies is presented, with the emphasis on the development of the ex vivo expansion of corneal limbal epithelial cells (presumed to be progenitor or stem cells) and the creation of transplantable epithelial constructs. The use of naturally derived biomaterials (collagen, fibrin, amnion, etc.) or synthetic polymers (polylactides, thermoresponsive polymers, etc.) as substrata in these constructs is critically analyzed. Emphasis is placed on the templates from silk proteins, which are being developed by the authors.
AB - This chapter discusses the effect on vision of a large group of pathological conditions, known as ocular surface disorders (OSDs), and presents the therapeutic strategies to reconstruct the abnormal ocular surface. If left untreated, most of the OSDs will lead to partial or total loss of eyesight, especially when limbal stem cell deficiency is involved. An overview of various treatment strategies is presented, with the emphasis on the development of the ex vivo expansion of corneal limbal epithelial cells (presumed to be progenitor or stem cells) and the creation of transplantable epithelial constructs. The use of naturally derived biomaterials (collagen, fibrin, amnion, etc.) or synthetic polymers (polylactides, thermoresponsive polymers, etc.) as substrata in these constructs is critically analyzed. Emphasis is placed on the templates from silk proteins, which are being developed by the authors.
KW - Corneal limbal epithelial cells
KW - Epithelial constructs
KW - Naturally derived biomaterial templates
KW - Ocular surface disorders
KW - Synthetic biomaterial templates
UR - http://www.scopus.com/inward/record.url?scp=84979965564&partnerID=8YFLogxK
U2 - 10.1016/B978-0-08-100147-9.00008-0
DO - 10.1016/B978-0-08-100147-9.00008-0
M3 - Chapter
AN - SCOPUS:84979965564
SN - 9780081001479
VL - 112
T3 - Woodhead Publishing Series in Biomaterials
SP - 179
EP - 218
BT - Biomaterials and Regenerative Medicine in Ophthalmology
A2 - Chirila, T V
A2 - Harkin, D
PB - Elsevier
ER -