Reciprocal Regulation of 11β-HSDs May Predict Steroid Sensitivity in Childhood Nephrotic Syndrome

Shuji Sai, Masaki Yamamoto, Rie Yamaguchi, Karen E Chapman, Teruaki Hongo

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Childhood nephrotic syndrome, in which steroid-dependence occurs concurrently with steroid-resistance, requires aggressive therapy to prevent relapse. Predictive biomarkers that can be used to stratify treatment are urgently needed. Here we report that reciprocal regulation of the glucocorticoid metabolizing enzymes, 11β-hydroxysteroid dehydrogenase types 1 and 2, is associated with steroid-responsiveness and disease remission in childhood nephrotic syndrome, potentially providing a marker to identify patients in which aggressive therapy is required.

Original languageEnglish
JournalPediatrics
Volume138
Issue number3
DOIs
Publication statusPublished - Sep 2016

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