TY - JOUR
T1 - Recent developments in frailty identification, management, risk factors and prevention
T2 - A narrative review of leading journals in geriatrics and gerontology
AU - Frailty Epidemiology Research Network (EPI-FRAIL)
AU - Dent, Elsa
AU - Hanlon, Peter
AU - Sim, Marc
AU - Jylhävä, Juulia
AU - Liu, Zuyun
AU - Vetrano, Davide L.
AU - Stolz, Erwin
AU - Pérez-Zepeda, Mario Ulises
AU - Crabtree, Daniel
AU - Nicholson, Caroline
AU - Job, Jenny
AU - Ambagtsheer, Rachel C.
AU - Ward, Paul R.
AU - Shi, Sandra M.
AU - Huynh, Quan
AU - Hoogendijk, Emiel O.
PY - 2023/11
Y1 - 2023/11
N2 - Frailty is an age-related clinical condition characterised by an increased susceptibility to stressors and an elevated risk of adverse outcomes such as mortality. In the light of global population ageing, the prevalence of frailty is expected to soar in coming decades. This narrative review provides critical insights into recent developments and emerging practices in frailty research regarding identification, management, risk factors, and prevention. We searched journals in the top two quartiles of geriatrics and gerontology (from Clarivate Journal Citation Reports) for articles published between 01 January 2018 and 20 December 2022. Several recent developments were identified, including new biomarkers and biomarker panels for frailty screening and diagnosis, using artificial intelligence to identify frailty, and investigating the altered response to medications by older adults with frailty. Other areas with novel developments included exercise (including technology-based exercise), multidimensional interventions, person-centred and integrated care, assistive technologies, analysis of frailty transitions, risk-factors, clinical guidelines, COVID-19, and potential future treatments. This review identified a strong need for the implementation and evaluation of cost-effective, community-based interventions to manage and prevent frailty. Our findings highlight the need to better identify and support older adults with frailty and involve those with frailty in shared decision-making regarding their care.
AB - Frailty is an age-related clinical condition characterised by an increased susceptibility to stressors and an elevated risk of adverse outcomes such as mortality. In the light of global population ageing, the prevalence of frailty is expected to soar in coming decades. This narrative review provides critical insights into recent developments and emerging practices in frailty research regarding identification, management, risk factors, and prevention. We searched journals in the top two quartiles of geriatrics and gerontology (from Clarivate Journal Citation Reports) for articles published between 01 January 2018 and 20 December 2022. Several recent developments were identified, including new biomarkers and biomarker panels for frailty screening and diagnosis, using artificial intelligence to identify frailty, and investigating the altered response to medications by older adults with frailty. Other areas with novel developments included exercise (including technology-based exercise), multidimensional interventions, person-centred and integrated care, assistive technologies, analysis of frailty transitions, risk-factors, clinical guidelines, COVID-19, and potential future treatments. This review identified a strong need for the implementation and evaluation of cost-effective, community-based interventions to manage and prevent frailty. Our findings highlight the need to better identify and support older adults with frailty and involve those with frailty in shared decision-making regarding their care.
KW - Aged
KW - Biomarkers
KW - Frailty
KW - Geriatric Assessment
KW - Risk Factors
UR - http://www.scopus.com/inward/record.url?scp=85173240185&partnerID=8YFLogxK
U2 - 10.1016/j.arr.2023.102082
DO - 10.1016/j.arr.2023.102082
M3 - Review article
C2 - 37797723
AN - SCOPUS:85173240185
SN - 1568-1637
VL - 91
JO - Ageing Research Reviews
JF - Ageing Research Reviews
M1 - 102082
ER -