TY - JOUR
T1 - Realistic simulation and experiment reveals the importance of scatterer microstructure in optical coherence tomography image formation
AU - Ossowski, Paweł
AU - Curatolo, Andrea
AU - Sampson, David D.
AU - Munro, Peter R.T.
PY - 2018/7/1
Y1 - 2018/7/1
N2 - Realistic simulation of image formation in optical coherence tomography, based on Maxwell’s equations, has recently been demonstrated for sample volumes of practical significance. Yet, there remains a limitation whereby reducing the size of cells used to construct a computational grid, thus allowing for more realistic representation of scatterer microstructure, necessarily reduces the overall sample size that can be modelled. This is a significant problem since, as is well known, the microstructure of a scatterer significantly influences its scattering properties. Here we demonstrate that optimized scatterer design can overcome this problem resulting in good agreement between simulated and experimental images for a structured phantom. This approach to OCT image simulation allows for image formation for biological tissues to be simulated with unprecedented realism.
AB - Realistic simulation of image formation in optical coherence tomography, based on Maxwell’s equations, has recently been demonstrated for sample volumes of practical significance. Yet, there remains a limitation whereby reducing the size of cells used to construct a computational grid, thus allowing for more realistic representation of scatterer microstructure, necessarily reduces the overall sample size that can be modelled. This is a significant problem since, as is well known, the microstructure of a scatterer significantly influences its scattering properties. Here we demonstrate that optimized scatterer design can overcome this problem resulting in good agreement between simulated and experimental images for a structured phantom. This approach to OCT image simulation allows for image formation for biological tissues to be simulated with unprecedented realism.
UR - http://www.scopus.com/inward/record.url?scp=85049370779&partnerID=8YFLogxK
U2 - 10.1364/BOE.9.003122
DO - 10.1364/BOE.9.003122
M3 - Article
C2 - 29984087
AN - SCOPUS:85049370779
SN - 2156-7085
VL - 9
SP - 3122
EP - 3136
JO - Biomedical Optics Express
JF - Biomedical Optics Express
IS - 7
M1 - #328129
ER -