Rates of age- and amyloid β-associated cortical atrophy in older adults with superior memory performance

Christa Dang, N. Yassi, Karra D. Harrington, Ying Xia, Yen Ying Lim, D. Ames, Simon M. Laws, Martha Hickey, Stephanie Rainey-Smith, Hamid R. Sohrabi, James D. Doecke, Jurgen Fripp, Olivier Salvado, Peter J. Snyder, Michael Weinborn, Victor L. Villemagne, Christopher C. Rowe, Colin L. Masters, Paul Maruff, Brian R. Chambers & 19 others Edmond Chiu, Roger Clarnette, D. Darby, Mary Davison, John Drago, P. Drysdale, Jacqueline Gilbert, K. Lim, Nicola Lautenschlager, Dina LoGiudice, P. McCardle, S. McFarlane, Alastair Mander, John Merory, Daniel O'Connor, Ron Scholes, Mathew Samuel, Darshan Trivedi, Michael Woodward

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Abstract

Introduction: Superior cognitive performance in older adults may reflect underlying resistance to age-associated neurodegeneration. While elevated amyloid β (Aβ) deposition (Aβ+) has been associated with increased cortical atrophy, it remains unknown whether “SuperAgers” may be protected from Aβ-associated neurodegeneration. Methods: Neuropsychologically defined SuperAgers (n = 172) and cognitively normal for age (n = 172) older adults from the Australian Imaging, Biomarkers and Lifestyle study were case matched. Rates of cortical atrophy over 8 years were examined by SuperAger classification and Aβ status. Results: Of the case-matched SuperAgers and cognitively normal for age older adults, 40.7% and 40.1%, respectively, were Aβ+. Rates of age- and Aβ-associated atrophy did not differ between the groups on any measure. Aβ− individuals displayed the slowest rates of atrophy. Discussion: Maintenance of superior memory in late life does not reflect resistance to age- or Aβ-associated atrophy. However, those individuals who reached old age without cognitive impairment nor elevated Aβ deposition (i.e. Aβ−) displayed reduced rates of cortical atrophy.

Original languageEnglish
Pages (from-to)566-575
Number of pages10
JournalAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume11
DOIs
Publication statusPublished - 1 Dec 2019

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Dang, Christa ; Yassi, N. ; Harrington, Karra D. ; Xia, Ying ; Lim, Yen Ying ; Ames, D. ; Laws, Simon M. ; Hickey, Martha ; Rainey-Smith, Stephanie ; Sohrabi, Hamid R. ; Doecke, James D. ; Fripp, Jurgen ; Salvado, Olivier ; Snyder, Peter J. ; Weinborn, Michael ; Villemagne, Victor L. ; Rowe, Christopher C. ; Masters, Colin L. ; Maruff, Paul ; Chambers, Brian R. ; Chiu, Edmond ; Clarnette, Roger ; Darby, D. ; Davison, Mary ; Drago, John ; Drysdale, P. ; Gilbert, Jacqueline ; Lim, K. ; Lautenschlager, Nicola ; LoGiudice, Dina ; McCardle, P. ; McFarlane, S. ; Mander, Alastair ; Merory, John ; O'Connor, Daniel ; Scholes, Ron ; Samuel, Mathew ; Trivedi, Darshan ; Woodward, Michael. / Rates of age- and amyloid β-associated cortical atrophy in older adults with superior memory performance. In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 2019 ; Vol. 11. pp. 566-575.
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title = "Rates of age- and amyloid β-associated cortical atrophy in older adults with superior memory performance",
abstract = "Introduction: Superior cognitive performance in older adults may reflect underlying resistance to age-associated neurodegeneration. While elevated amyloid β (Aβ) deposition (Aβ+) has been associated with increased cortical atrophy, it remains unknown whether “SuperAgers” may be protected from Aβ-associated neurodegeneration. Methods: Neuropsychologically defined SuperAgers (n = 172) and cognitively normal for age (n = 172) older adults from the Australian Imaging, Biomarkers and Lifestyle study were case matched. Rates of cortical atrophy over 8 years were examined by SuperAger classification and Aβ status. Results: Of the case-matched SuperAgers and cognitively normal for age older adults, 40.7{\%} and 40.1{\%}, respectively, were Aβ+. Rates of age- and Aβ-associated atrophy did not differ between the groups on any measure. Aβ− individuals displayed the slowest rates of atrophy. Discussion: Maintenance of superior memory in late life does not reflect resistance to age- or Aβ-associated atrophy. However, those individuals who reached old age without cognitive impairment nor elevated Aβ deposition (i.e. Aβ−) displayed reduced rates of cortical atrophy.",
keywords = "Aging, Alzheimer's disease, Memory, Neurodegeneration, β-amyloid",
author = "Christa Dang and N. Yassi and Harrington, {Karra D.} and Ying Xia and Lim, {Yen Ying} and D. Ames and Laws, {Simon M.} and Martha Hickey and Stephanie Rainey-Smith and Sohrabi, {Hamid R.} and Doecke, {James D.} and Jurgen Fripp and Olivier Salvado and Snyder, {Peter J.} and Michael Weinborn and Villemagne, {Victor L.} and Rowe, {Christopher C.} and Masters, {Colin L.} and Paul Maruff and Chambers, {Brian R.} and Edmond Chiu and Roger Clarnette and D. Darby and Mary Davison and John Drago and P. Drysdale and Jacqueline Gilbert and K. Lim and Nicola Lautenschlager and Dina LoGiudice and P. McCardle and S. McFarlane and Alastair Mander and John Merory and Daniel O'Connor and Ron Scholes and Mathew Samuel and Darshan Trivedi and Michael Woodward",
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Dang, C, Yassi, N, Harrington, KD, Xia, Y, Lim, YY, Ames, D, Laws, SM, Hickey, M, Rainey-Smith, S, Sohrabi, HR, Doecke, JD, Fripp, J, Salvado, O, Snyder, PJ, Weinborn, M, Villemagne, VL, Rowe, CC, Masters, CL, Maruff, P, Chambers, BR, Chiu, E, Clarnette, R, Darby, D, Davison, M, Drago, J, Drysdale, P, Gilbert, J, Lim, K, Lautenschlager, N, LoGiudice, D, McCardle, P, McFarlane, S, Mander, A, Merory, J, O'Connor, D, Scholes, R, Samuel, M, Trivedi, D & Woodward, M 2019, 'Rates of age- and amyloid β-associated cortical atrophy in older adults with superior memory performance' Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, vol. 11, pp. 566-575. https://doi.org/10.1016/j.dadm.2019.05.005

Rates of age- and amyloid β-associated cortical atrophy in older adults with superior memory performance. / Dang, Christa; Yassi, N.; Harrington, Karra D.; Xia, Ying; Lim, Yen Ying; Ames, D.; Laws, Simon M.; Hickey, Martha; Rainey-Smith, Stephanie; Sohrabi, Hamid R.; Doecke, James D.; Fripp, Jurgen; Salvado, Olivier; Snyder, Peter J.; Weinborn, Michael; Villemagne, Victor L.; Rowe, Christopher C.; Masters, Colin L.; Maruff, Paul; Chambers, Brian R.; Chiu, Edmond; Clarnette, Roger; Darby, D.; Davison, Mary; Drago, John; Drysdale, P.; Gilbert, Jacqueline; Lim, K.; Lautenschlager, Nicola; LoGiudice, Dina; McCardle, P.; McFarlane, S.; Mander, Alastair; Merory, John; O'Connor, Daniel; Scholes, Ron; Samuel, Mathew; Trivedi, Darshan; Woodward, Michael.

In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, Vol. 11, 01.12.2019, p. 566-575.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Rates of age- and amyloid β-associated cortical atrophy in older adults with superior memory performance

AU - Dang, Christa

AU - Yassi, N.

AU - Harrington, Karra D.

AU - Xia, Ying

AU - Lim, Yen Ying

AU - Ames, D.

AU - Laws, Simon M.

AU - Hickey, Martha

AU - Rainey-Smith, Stephanie

AU - Sohrabi, Hamid R.

AU - Doecke, James D.

AU - Fripp, Jurgen

AU - Salvado, Olivier

AU - Snyder, Peter J.

AU - Weinborn, Michael

AU - Villemagne, Victor L.

AU - Rowe, Christopher C.

AU - Masters, Colin L.

AU - Maruff, Paul

AU - Chambers, Brian R.

AU - Chiu, Edmond

AU - Clarnette, Roger

AU - Darby, D.

AU - Davison, Mary

AU - Drago, John

AU - Drysdale, P.

AU - Gilbert, Jacqueline

AU - Lim, K.

AU - Lautenschlager, Nicola

AU - LoGiudice, Dina

AU - McCardle, P.

AU - McFarlane, S.

AU - Mander, Alastair

AU - Merory, John

AU - O'Connor, Daniel

AU - Scholes, Ron

AU - Samuel, Mathew

AU - Trivedi, Darshan

AU - Woodward, Michael

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Introduction: Superior cognitive performance in older adults may reflect underlying resistance to age-associated neurodegeneration. While elevated amyloid β (Aβ) deposition (Aβ+) has been associated with increased cortical atrophy, it remains unknown whether “SuperAgers” may be protected from Aβ-associated neurodegeneration. Methods: Neuropsychologically defined SuperAgers (n = 172) and cognitively normal for age (n = 172) older adults from the Australian Imaging, Biomarkers and Lifestyle study were case matched. Rates of cortical atrophy over 8 years were examined by SuperAger classification and Aβ status. Results: Of the case-matched SuperAgers and cognitively normal for age older adults, 40.7% and 40.1%, respectively, were Aβ+. Rates of age- and Aβ-associated atrophy did not differ between the groups on any measure. Aβ− individuals displayed the slowest rates of atrophy. Discussion: Maintenance of superior memory in late life does not reflect resistance to age- or Aβ-associated atrophy. However, those individuals who reached old age without cognitive impairment nor elevated Aβ deposition (i.e. Aβ−) displayed reduced rates of cortical atrophy.

AB - Introduction: Superior cognitive performance in older adults may reflect underlying resistance to age-associated neurodegeneration. While elevated amyloid β (Aβ) deposition (Aβ+) has been associated with increased cortical atrophy, it remains unknown whether “SuperAgers” may be protected from Aβ-associated neurodegeneration. Methods: Neuropsychologically defined SuperAgers (n = 172) and cognitively normal for age (n = 172) older adults from the Australian Imaging, Biomarkers and Lifestyle study were case matched. Rates of cortical atrophy over 8 years were examined by SuperAger classification and Aβ status. Results: Of the case-matched SuperAgers and cognitively normal for age older adults, 40.7% and 40.1%, respectively, were Aβ+. Rates of age- and Aβ-associated atrophy did not differ between the groups on any measure. Aβ− individuals displayed the slowest rates of atrophy. Discussion: Maintenance of superior memory in late life does not reflect resistance to age- or Aβ-associated atrophy. However, those individuals who reached old age without cognitive impairment nor elevated Aβ deposition (i.e. Aβ−) displayed reduced rates of cortical atrophy.

KW - Aging

KW - Alzheimer's disease

KW - Memory

KW - Neurodegeneration

KW - β-amyloid

UR - http://www.scopus.com/inward/record.url?scp=85070370939&partnerID=8YFLogxK

U2 - 10.1016/j.dadm.2019.05.005

DO - 10.1016/j.dadm.2019.05.005

M3 - Article

VL - 11

SP - 566

EP - 575

JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

SN - 2352-8729

ER -