Rate of Nonsurveillance and Advanced Hepatocellular Carcinoma at Diagnosis in Chronic Liver Disease

Yi Huang; Michael C. Wallace; Leon A. Adams; Gerry MacQuillan; George Garas; John Ferguson; Shaun Samuelson; Jonathan Tibballs; Gary P. Jeffrey

doi:10.1097/MCG.0000000000000916

Rate of Nonsurveillance and Advanced Hepatocellular Carcinoma at Diagnosis in Chronic Liver Disease

Yi Huang, Michael C. Wallace, Leon A. Adams, Gerry MacQuillan, George Garas, John Ferguson, Shaun Samuelson, Jonathan Tibballs, Gary P. Jeffrey

UWA Medical School

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Aims:Ultrasound surveillance for hepatocellular carcinoma (HCC) is recommended in cirrhotic patients to allow early diagnosis. This study investigated risk factors for nonsurveillance and advanced HCC at diagnosis and their effect on survival.Materials and Methods:Two hundred seventy HCC patients were included. Clinical data were collected from hospital databases.Results:One hundred twenty-eight (47.1%) patients had 6-monthly ultrasound surveillance before HCC diagnosis. Ninety-two (34.1%) patients had advanced HCC (multifocal or total diameter 6cm) at diagnosis. The nonsurveillance rate was significantly higher in nonalcoholic fatty liver disease (NAFLD) (79%) compared with other causes of chronic liver disease (31.6% to 58.1%, P

Original language	English
Pages (from-to)	551-556
Number of pages	6
Journal	Journal of Clinical Gastroenterology
Volume	52
Issue number	6
DOIs	https://doi.org/10.1097/MCG.0000000000000916
Publication status	Published - Jul 2018

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title = "Rate of Nonsurveillance and Advanced Hepatocellular Carcinoma at Diagnosis in Chronic Liver Disease",

abstract = "Aims:Ultrasound surveillance for hepatocellular carcinoma (HCC) is recommended in cirrhotic patients to allow early diagnosis. This study investigated risk factors for nonsurveillance and advanced HCC at diagnosis and their effect on survival.Materials and Methods:Two hundred seventy HCC patients were included. Clinical data were collected from hospital databases.Results:One hundred twenty-eight (47.1%) patients had 6-monthly ultrasound surveillance before HCC diagnosis. Ninety-two (34.1%) patients had advanced HCC (multifocal or total diameter 6cm) at diagnosis. The nonsurveillance rate was significantly higher in nonalcoholic fatty liver disease (NAFLD) (79%) compared with other causes of chronic liver disease (31.6% to 58.1%, P",

keywords = "chronic liver disease, alcohol consumption, magnetic resonance imaging, CLINICAL-PRACTICE, SURVEILLANCE, MANAGEMENT, PATTERNS, CANCER",

author = "Yi Huang and Wallace, {Michael C.} and Adams, {Leon A.} and Gerry MacQuillan and George Garas and John Ferguson and Shaun Samuelson and Jonathan Tibballs and Jeffrey, {Gary P.}",

year = "2018",

month = jul,

doi = "10.1097/MCG.0000000000000916",

language = "English",

volume = "52",

pages = "551--556",

journal = "Journal of Clinical Gastroenterology",

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}

TY - JOUR

T1 - Rate of Nonsurveillance and Advanced Hepatocellular Carcinoma at Diagnosis in Chronic Liver Disease

AU - Huang, Yi

AU - Wallace, Michael C.

AU - Adams, Leon A.

AU - MacQuillan, Gerry

AU - Garas, George

AU - Ferguson, John

AU - Samuelson, Shaun

AU - Tibballs, Jonathan

AU - Jeffrey, Gary P.

PY - 2018/7

Y1 - 2018/7

N2 - Aims:Ultrasound surveillance for hepatocellular carcinoma (HCC) is recommended in cirrhotic patients to allow early diagnosis. This study investigated risk factors for nonsurveillance and advanced HCC at diagnosis and their effect on survival.Materials and Methods:Two hundred seventy HCC patients were included. Clinical data were collected from hospital databases.Results:One hundred twenty-eight (47.1%) patients had 6-monthly ultrasound surveillance before HCC diagnosis. Ninety-two (34.1%) patients had advanced HCC (multifocal or total diameter 6cm) at diagnosis. The nonsurveillance rate was significantly higher in nonalcoholic fatty liver disease (NAFLD) (79%) compared with other causes of chronic liver disease (31.6% to 58.1%, P

AB - Aims:Ultrasound surveillance for hepatocellular carcinoma (HCC) is recommended in cirrhotic patients to allow early diagnosis. This study investigated risk factors for nonsurveillance and advanced HCC at diagnosis and their effect on survival.Materials and Methods:Two hundred seventy HCC patients were included. Clinical data were collected from hospital databases.Results:One hundred twenty-eight (47.1%) patients had 6-monthly ultrasound surveillance before HCC diagnosis. Ninety-two (34.1%) patients had advanced HCC (multifocal or total diameter 6cm) at diagnosis. The nonsurveillance rate was significantly higher in nonalcoholic fatty liver disease (NAFLD) (79%) compared with other causes of chronic liver disease (31.6% to 58.1%, P

KW - chronic liver disease

KW - alcohol consumption

KW - magnetic resonance imaging

KW - CLINICAL-PRACTICE

KW - SURVEILLANCE

KW - MANAGEMENT

KW - PATTERNS

KW - CANCER

U2 - 10.1097/MCG.0000000000000916

DO - 10.1097/MCG.0000000000000916

M3 - Article

SN - 0192-0790

VL - 52

SP - 551

EP - 556

JO - Journal of Clinical Gastroenterology

JF - Journal of Clinical Gastroenterology

IS - 6

ER -

Rate of Nonsurveillance and Advanced Hepatocellular Carcinoma at Diagnosis in Chronic Liver Disease

Abstract

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