Randomized single blind trial of two low-volume bowel preparations for screening computed tomographic colongraphy

Geoffrey Forbes, J.T. Edwards, N.M. Foster, C.J. Wood, R.M. Mendelson

    Research output: Contribution to journalArticlepeer-review

    3 Citations (Scopus)


    Background: Bowel preparation is an important part of computed tomographic colonography (CTC); we evaluated two small-volume preparations for screening CTC with regard to quality of preparation and patient acceptability.Methods: Asymptornatic subjects at average risk for colorectal cancer from a community-based CTC screening program were randomized to bowel preparation comprising magnesium/bisacodyl/picolax or polyethylene glycol (PEG)/picolax. CTC images were evaluated by a blinded investigator for residual feces and fluid; subjects completed a questionnaire regarding acceptability of the preparation.Results: In 176 subjects randomized to magnesium/bisacodyl/picolax (n = 82) or PEG/picolax (n = 94), the former preparation was discontinued because of syncope or presyncope in four (5%) subjects. Another 137 subjects received PEG/picolax without a significant adverse event. There were no other major differences in acceptability of the preparations as reported by subjects. The quality of bowel preparations for reporting CTC was similar.Conclusion: For subjects having screening CTC, both small-volume bowel preparations are generally well tolerated and result in minimal fluid and fecal residue; however, the magnesium/bisacodyl/picolax preparation was accompanied by an unacceptable incidence of syncope and is no longer used by us.
    Original languageEnglish
    Pages (from-to)48-52
    JournalAbdominal Imaging
    Publication statusPublished - 2005


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