Randomised controlled trial of daily versus stoss vitamin D therapy in Aboriginal children

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    Abstract

    © 2014 The Authors. Journal of Paediatrics and Child Health © 2014 Paediatrics and Child Health Division (Royal Australasian College of Physicians). Aim The prevalence of vitamin D deficiency has risen in countries with a high ultraviolet index and sunny environment such as Australia. There is lack of information on vitamin D status and best possible therapy in Australian Aboriginal children. We aim to (i) describe the vitamin D status in an opportunistic sample of Aboriginal children in Western Australia and (ii) compare the efficacy of oral daily vitamin D with oral stoss vitamin D therapy in this sample. Method Participants were recruited from a metropolitan area (31′ S) and a rural area (17′ S). Those with a 25(OH)D level less than 78 nmol/L were randomised to receive daily or stoss vitamin D therapy with follow-up at 4-6 months and 9-12 months. Biochemical and clinical parameters such as 25(OH)D, alkaline phosphatase, calcium and sun exposure were collected. Results Seventy-three participants were enrolled (61 from a metropolitan and 12 from a rural area). 25(OH)D levels were greater than 78 nmol/L in 9/12 (75%) participants in the rural group and 21/61 (34%) in the metropolitan group. 25(OH)D levels were less than 78 nmol/L in 43/73 (59%) participants. Of these, 34/43 (79%) were insufficient (50-78 nmol/L), 8/43 (19%) mildly deficient (27.5-50 nmol/L) and 1/43 (2%) deficient (
    Original languageEnglish
    Pages (from-to)626-631
    JournalJournal of Paediatrics and Child Health
    Volume51
    Issue number6
    DOIs
    Publication statusPublished - 2015

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