Radiotherapy dose-distribution to the perirectal fat space (PRS) is related to gastrointestinal control-related complications

S L Gulliford, S Ghose, M A Ebert, A Kennedy, J Dowling, J Mitra, D J Joseph, J W Denham

Research output: Contribution to journalArticle

3 Citations (Scopus)
173 Downloads (Pure)

Abstract

Traditionally rectal symptoms following pelvic/prostate radiotherapy are correlated to the dosimetry of the anorectum or a substructure of this. It has been suggested that the perirectal fat space (PRS) surrounding the rectum may also be relevant. This study considers the delineation and dosimetry of the PRS related to both rectal bleeding and control-related toxicity. Initially, a case-control cohort of 100 patients from the RADAR study were chosen based on presence/absence of rectal control-related toxicity. Automated contouring was developed to delineate the PRS. 79 of the 100 auto-segmentations were considered successful. Balanced case-control cohorts were defined from these cases. Atlas of Complication Incidence (ACI) were generated to relate the DVH of the PRS with specific rectal symptoms; rectal bleeding and control-related symptoms (LENT/SOM). ACI demonstrated that control-related symptoms were related to the dose distribution to the PRS which was confirmed with Wilcoxon rank sum test (p < 0.05). To the authors knowledge this is the first study implicating the dose distribution to the PRS to the incidence of control-related symptoms of rectal toxicity.

Original languageEnglish
Pages (from-to)62-70
Number of pages9
JournalClinical and translational radiation oncology
Volume7
DOIs
Publication statusPublished - Dec 2017

Fingerprint

Radiotherapy
Fats
Atlases
Nonparametric Statistics
Incidence
Hemorrhage
Rectum
Prostate

Cite this

@article{e0cf115dbf2546b1bfbb1d4ae19ad720,
title = "Radiotherapy dose-distribution to the perirectal fat space (PRS) is related to gastrointestinal control-related complications",
abstract = "Traditionally rectal symptoms following pelvic/prostate radiotherapy are correlated to the dosimetry of the anorectum or a substructure of this. It has been suggested that the perirectal fat space (PRS) surrounding the rectum may also be relevant. This study considers the delineation and dosimetry of the PRS related to both rectal bleeding and control-related toxicity. Initially, a case-control cohort of 100 patients from the RADAR study were chosen based on presence/absence of rectal control-related toxicity. Automated contouring was developed to delineate the PRS. 79 of the 100 auto-segmentations were considered successful. Balanced case-control cohorts were defined from these cases. Atlas of Complication Incidence (ACI) were generated to relate the DVH of the PRS with specific rectal symptoms; rectal bleeding and control-related symptoms (LENT/SOM). ACI demonstrated that control-related symptoms were related to the dose distribution to the PRS which was confirmed with Wilcoxon rank sum test (p < 0.05). To the authors knowledge this is the first study implicating the dose distribution to the PRS to the incidence of control-related symptoms of rectal toxicity.",
author = "Gulliford, {S L} and S Ghose and Ebert, {M A} and A Kennedy and J Dowling and J Mitra and Joseph, {D J} and Denham, {J W}",
year = "2017",
month = "12",
doi = "10.1016/j.ctro.2017.10.002",
language = "English",
volume = "7",
pages = "62--70",
journal = "Clinical and translational radiation oncology",
issn = "2405-6308",

}

Radiotherapy dose-distribution to the perirectal fat space (PRS) is related to gastrointestinal control-related complications. / Gulliford, S L; Ghose, S; Ebert, M A; Kennedy, A; Dowling, J; Mitra, J; Joseph, D J; Denham, J W.

In: Clinical and translational radiation oncology, Vol. 7, 12.2017, p. 62-70.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Radiotherapy dose-distribution to the perirectal fat space (PRS) is related to gastrointestinal control-related complications

AU - Gulliford, S L

AU - Ghose, S

AU - Ebert, M A

AU - Kennedy, A

AU - Dowling, J

AU - Mitra, J

AU - Joseph, D J

AU - Denham, J W

PY - 2017/12

Y1 - 2017/12

N2 - Traditionally rectal symptoms following pelvic/prostate radiotherapy are correlated to the dosimetry of the anorectum or a substructure of this. It has been suggested that the perirectal fat space (PRS) surrounding the rectum may also be relevant. This study considers the delineation and dosimetry of the PRS related to both rectal bleeding and control-related toxicity. Initially, a case-control cohort of 100 patients from the RADAR study were chosen based on presence/absence of rectal control-related toxicity. Automated contouring was developed to delineate the PRS. 79 of the 100 auto-segmentations were considered successful. Balanced case-control cohorts were defined from these cases. Atlas of Complication Incidence (ACI) were generated to relate the DVH of the PRS with specific rectal symptoms; rectal bleeding and control-related symptoms (LENT/SOM). ACI demonstrated that control-related symptoms were related to the dose distribution to the PRS which was confirmed with Wilcoxon rank sum test (p < 0.05). To the authors knowledge this is the first study implicating the dose distribution to the PRS to the incidence of control-related symptoms of rectal toxicity.

AB - Traditionally rectal symptoms following pelvic/prostate radiotherapy are correlated to the dosimetry of the anorectum or a substructure of this. It has been suggested that the perirectal fat space (PRS) surrounding the rectum may also be relevant. This study considers the delineation and dosimetry of the PRS related to both rectal bleeding and control-related toxicity. Initially, a case-control cohort of 100 patients from the RADAR study were chosen based on presence/absence of rectal control-related toxicity. Automated contouring was developed to delineate the PRS. 79 of the 100 auto-segmentations were considered successful. Balanced case-control cohorts were defined from these cases. Atlas of Complication Incidence (ACI) were generated to relate the DVH of the PRS with specific rectal symptoms; rectal bleeding and control-related symptoms (LENT/SOM). ACI demonstrated that control-related symptoms were related to the dose distribution to the PRS which was confirmed with Wilcoxon rank sum test (p < 0.05). To the authors knowledge this is the first study implicating the dose distribution to the PRS to the incidence of control-related symptoms of rectal toxicity.

U2 - 10.1016/j.ctro.2017.10.002

DO - 10.1016/j.ctro.2017.10.002

M3 - Article

VL - 7

SP - 62

EP - 70

JO - Clinical and translational radiation oncology

JF - Clinical and translational radiation oncology

SN - 2405-6308

ER -