Radiological and histopathological examination of apparent lytic lesions in allograft long bones-No cause for concern

Mike Kent; Greg Brooker; Ryan Fisher; Geraldine Goh; Ranieri Falcao Aguiar; John Papadimitriou; Daniel Wong; Richard Carey-Smith; Anne Cowie

doi:10.1016/j.jor.2015.10.021

Radiological and histopathological examination of apparent lytic lesions in allograft long bones-No cause for concern

Mike Kent, Greg Brooker, Ryan Fisher, Geraldine Goh, Ranieri Falcao Aguiar, John Papadimitriou, Daniel Wong, Richard Carey-Smith, Anne Cowie

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVE: Identify the nature of apparent lytic lesions within human allograft specimens from patients with no known malignancy, using radiological and histopathological analysis.

METHODS: 123 Post-retrieval radiographs from 23 donors were examined. Sixty-seven radiographs were noted to show apparent lytic lesions. The number, size, character and position of the apparent lesions were recorded.

RESULTS: CT scanning of 9 specimens confirmed the lesions to be of air pockets causing artefact. Histopathological analysis showed no malignant or pathological process.

CONCLUSIONS: Apparent lesions were not pathological.

PRACTICE IMPLICATIONS: Specimens with similar appearances, in donors with no malignancy, can be safely used in donation.

Original language	English
Pages (from-to)	S152-6
Number of pages	5
Journal	Journal of Orthopaedics
Volume	12
Issue number	Suppl 2
DOIs	https://doi.org/10.1016/j.jor.2015.10.021
Publication status	Published - Dec 2015

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10.1016/j.jor.2015.10.021

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title = "Radiological and histopathological examination of apparent lytic lesions in allograft long bones-No cause for concern",

abstract = "OBJECTIVE: Identify the nature of apparent lytic lesions within human allograft specimens from patients with no known malignancy, using radiological and histopathological analysis.METHODS: 123 Post-retrieval radiographs from 23 donors were examined. Sixty-seven radiographs were noted to show apparent lytic lesions. The number, size, character and position of the apparent lesions were recorded.RESULTS: CT scanning of 9 specimens confirmed the lesions to be of air pockets causing artefact. Histopathological analysis showed no malignant or pathological process.CONCLUSIONS: Apparent lesions were not pathological.PRACTICE IMPLICATIONS: Specimens with similar appearances, in donors with no malignancy, can be safely used in donation.",

author = "Mike Kent and Greg Brooker and Ryan Fisher and Geraldine Goh and Aguiar, \{Ranieri Falcao\} and John Papadimitriou and Daniel Wong and Richard Carey-Smith and Anne Cowie",

year = "2015",

month = dec,

doi = "10.1016/j.jor.2015.10.021",

language = "English",

volume = "12",

pages = "S152--6",

journal = "Journal of Orthopaedics",

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publisher = "Elsevier",

number = "Suppl 2",

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TY - JOUR

T1 - Radiological and histopathological examination of apparent lytic lesions in allograft long bones-No cause for concern

AU - Kent, Mike

AU - Brooker, Greg

AU - Fisher, Ryan

AU - Goh, Geraldine

AU - Aguiar, Ranieri Falcao

AU - Papadimitriou, John

AU - Wong, Daniel

AU - Carey-Smith, Richard

AU - Cowie, Anne

PY - 2015/12

Y1 - 2015/12

N2 - OBJECTIVE: Identify the nature of apparent lytic lesions within human allograft specimens from patients with no known malignancy, using radiological and histopathological analysis.METHODS: 123 Post-retrieval radiographs from 23 donors were examined. Sixty-seven radiographs were noted to show apparent lytic lesions. The number, size, character and position of the apparent lesions were recorded.RESULTS: CT scanning of 9 specimens confirmed the lesions to be of air pockets causing artefact. Histopathological analysis showed no malignant or pathological process.CONCLUSIONS: Apparent lesions were not pathological.PRACTICE IMPLICATIONS: Specimens with similar appearances, in donors with no malignancy, can be safely used in donation.

AB - OBJECTIVE: Identify the nature of apparent lytic lesions within human allograft specimens from patients with no known malignancy, using radiological and histopathological analysis.METHODS: 123 Post-retrieval radiographs from 23 donors were examined. Sixty-seven radiographs were noted to show apparent lytic lesions. The number, size, character and position of the apparent lesions were recorded.RESULTS: CT scanning of 9 specimens confirmed the lesions to be of air pockets causing artefact. Histopathological analysis showed no malignant or pathological process.CONCLUSIONS: Apparent lesions were not pathological.PRACTICE IMPLICATIONS: Specimens with similar appearances, in donors with no malignancy, can be safely used in donation.

UR - https://www.scopus.com/pages/publications/84978323429

U2 - 10.1016/j.jor.2015.10.021

DO - 10.1016/j.jor.2015.10.021

M3 - Article

C2 - 27047215

SN - 0972-978X

VL - 12

SP - S152-6

JO - Journal of Orthopaedics

JF - Journal of Orthopaedics

IS - Suppl 2

ER -

Radiological and histopathological examination of apparent lytic lesions in allograft long bones-No cause for concern

Abstract

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