Radioguided occult lesion localisation using iodine-125 seeds ('ROLLIS') for removal of impalpable breast lesions: First Australian experience

Donna Taylor, Anita Bourke, Eliza Westcott, J. Burrage, B. Latham, P. Riley, H. Ballal, R. Kamyab, F. Frost, D. Dissanayake, J. Landman, Michael Phillips, Christobel Saunders

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Abstract

© 2015 The Royal Australian and New Zealand College of Radiologists. Introduction Approximately one-third of breast cancers are impalpable and require pre-operative image-guided localisation. Hook-wire localisation (HWL) is commonly used but has several disadvantages. Use of a low-activity radioactive iodine-125 seed is a promising alternative technique used in the USA and the Netherlands. This pilot study describes the first use of this in Australia. Methods In this prospective pilot study, 21 participants with biopsy-proven breast cancer underwent radioguided occult lesion localisation using iodine-125 seed(s) (ROLLIS) with insertion of a hook-wire for back up. Sentinel node biopsy was performed where indicated. Ease of hook-wire and seed insertion, duration of the procedure, dependence on the seed versus hook-wire during surgery, lesion location within the specimen, histopathology including size of radial margins, the ease of seed retrieval in pathology, and safe return of seeds for disposal were documented. Radiation dosimetry of staff was performed. Results All seeds were placed within 3.5 mm of the lesion. All lesions and seeds were removed. One participant needed re-excision for involved margins. Radiologists and surgeons both preferred ROLLIS. Surgeons were able to depend on the seed for localisation in all but one case. Sentinel node biopsy was successfully performed when required. Pathologists found seed retrieval quick and easy, with no detrimental effect on tissue processing. No radiation doses measurably above background were received by staff. Conclusion ROLLIS is an easily learnt, safe and effective alternative technique to standard HWL.
Original languageEnglish
Pages (from-to)411-420
JournalJournal of Medical Imaging and Radiation Oncology
Volume59
Issue number4
DOIs
Publication statusPublished - 2015

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Iodine
Seeds
Breast
Biopsy
Breast Neoplasms
Radiometry
Netherlands
Prospective Studies
Radiation
Pathology

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Taylor, Donna ; Bourke, Anita ; Westcott, Eliza ; Burrage, J. ; Latham, B. ; Riley, P. ; Ballal, H. ; Kamyab, R. ; Frost, F. ; Dissanayake, D. ; Landman, J. ; Phillips, Michael ; Saunders, Christobel. / Radioguided occult lesion localisation using iodine-125 seeds ('ROLLIS') for removal of impalpable breast lesions: First Australian experience. In: Journal of Medical Imaging and Radiation Oncology. 2015 ; Vol. 59, No. 4. pp. 411-420.
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author = "Donna Taylor and Anita Bourke and Eliza Westcott and J. Burrage and B. Latham and P. Riley and H. Ballal and R. Kamyab and F. Frost and D. Dissanayake and J. Landman and Michael Phillips and Christobel Saunders",
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Radioguided occult lesion localisation using iodine-125 seeds ('ROLLIS') for removal of impalpable breast lesions: First Australian experience. / Taylor, Donna; Bourke, Anita; Westcott, Eliza; Burrage, J.; Latham, B.; Riley, P.; Ballal, H.; Kamyab, R.; Frost, F.; Dissanayake, D.; Landman, J.; Phillips, Michael; Saunders, Christobel.

In: Journal of Medical Imaging and Radiation Oncology, Vol. 59, No. 4, 2015, p. 411-420.

Research output: Contribution to journalArticle

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T1 - Radioguided occult lesion localisation using iodine-125 seeds ('ROLLIS') for removal of impalpable breast lesions: First Australian experience

AU - Taylor, Donna

AU - Bourke, Anita

AU - Westcott, Eliza

AU - Burrage, J.

AU - Latham, B.

AU - Riley, P.

AU - Ballal, H.

AU - Kamyab, R.

AU - Frost, F.

AU - Dissanayake, D.

AU - Landman, J.

AU - Phillips, Michael

AU - Saunders, Christobel

PY - 2015

Y1 - 2015

N2 - © 2015 The Royal Australian and New Zealand College of Radiologists. Introduction Approximately one-third of breast cancers are impalpable and require pre-operative image-guided localisation. Hook-wire localisation (HWL) is commonly used but has several disadvantages. Use of a low-activity radioactive iodine-125 seed is a promising alternative technique used in the USA and the Netherlands. This pilot study describes the first use of this in Australia. Methods In this prospective pilot study, 21 participants with biopsy-proven breast cancer underwent radioguided occult lesion localisation using iodine-125 seed(s) (ROLLIS) with insertion of a hook-wire for back up. Sentinel node biopsy was performed where indicated. Ease of hook-wire and seed insertion, duration of the procedure, dependence on the seed versus hook-wire during surgery, lesion location within the specimen, histopathology including size of radial margins, the ease of seed retrieval in pathology, and safe return of seeds for disposal were documented. Radiation dosimetry of staff was performed. Results All seeds were placed within 3.5 mm of the lesion. All lesions and seeds were removed. One participant needed re-excision for involved margins. Radiologists and surgeons both preferred ROLLIS. Surgeons were able to depend on the seed for localisation in all but one case. Sentinel node biopsy was successfully performed when required. Pathologists found seed retrieval quick and easy, with no detrimental effect on tissue processing. No radiation doses measurably above background were received by staff. Conclusion ROLLIS is an easily learnt, safe and effective alternative technique to standard HWL.

AB - © 2015 The Royal Australian and New Zealand College of Radiologists. Introduction Approximately one-third of breast cancers are impalpable and require pre-operative image-guided localisation. Hook-wire localisation (HWL) is commonly used but has several disadvantages. Use of a low-activity radioactive iodine-125 seed is a promising alternative technique used in the USA and the Netherlands. This pilot study describes the first use of this in Australia. Methods In this prospective pilot study, 21 participants with biopsy-proven breast cancer underwent radioguided occult lesion localisation using iodine-125 seed(s) (ROLLIS) with insertion of a hook-wire for back up. Sentinel node biopsy was performed where indicated. Ease of hook-wire and seed insertion, duration of the procedure, dependence on the seed versus hook-wire during surgery, lesion location within the specimen, histopathology including size of radial margins, the ease of seed retrieval in pathology, and safe return of seeds for disposal were documented. Radiation dosimetry of staff was performed. Results All seeds were placed within 3.5 mm of the lesion. All lesions and seeds were removed. One participant needed re-excision for involved margins. Radiologists and surgeons both preferred ROLLIS. Surgeons were able to depend on the seed for localisation in all but one case. Sentinel node biopsy was successfully performed when required. Pathologists found seed retrieval quick and easy, with no detrimental effect on tissue processing. No radiation doses measurably above background were received by staff. Conclusion ROLLIS is an easily learnt, safe and effective alternative technique to standard HWL.

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JO - Journal of Medical Imaging and Radiation Oncology

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SN - 0004-8461

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