TY - JOUR
T1 - RADBIOMOD
T2 - A simple program for utilising biological modelling in radiotherapy plan evaluation
AU - Chang, Joe H.
AU - Gehrke, Christopher
AU - Prabhakar, Ramachandran
AU - Gill, Suki
AU - Wada, Morikatsu
AU - Lim Joon, Daryl
AU - Khoo, Vincent
N1 - Publisher Copyright:
© 2015 Associazione Italiana di Fisica Medica.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Purpose: Radiotherapy plan evaluation is currently performed by assessing physical parameters, which has many limitations. Biological modelling can potentially allow plan evaluation that is more reflective of clinical outcomes, however further research is required into this field before it can be used clinically. Methods: A simple program, RADBIOMOD, has been developed using Visual Basic for Applications (VBA) for Microsoft Excel that incorporates multiple different biological models for radiotherapy plan evaluation, including modified Poisson tumour control probability (TCP), modified Zaider-Minerbo TCP, Lyman-Kutcher-Burman normal tissue complication probability (NTCP), equivalent uniform dose (EUD), EUD-based TCP, EUD-based NTCP, and uncomplicated tumour control probability (UTCP). RADBIOMOD was compared to existing biological modelling calculators for 15 sample cases. Results: Comparing RADBIOMOD to the existing biological modelling calculators, all models tested had mean absolute errors and root mean square errors less than 1%. Conclusions: RADBIOMOD produces results that are non-significantly different from existing biological modelling calculators for the models tested. It is hoped that this freely available, user-friendly program will aid future research into biological modelling.
AB - Purpose: Radiotherapy plan evaluation is currently performed by assessing physical parameters, which has many limitations. Biological modelling can potentially allow plan evaluation that is more reflective of clinical outcomes, however further research is required into this field before it can be used clinically. Methods: A simple program, RADBIOMOD, has been developed using Visual Basic for Applications (VBA) for Microsoft Excel that incorporates multiple different biological models for radiotherapy plan evaluation, including modified Poisson tumour control probability (TCP), modified Zaider-Minerbo TCP, Lyman-Kutcher-Burman normal tissue complication probability (NTCP), equivalent uniform dose (EUD), EUD-based TCP, EUD-based NTCP, and uncomplicated tumour control probability (UTCP). RADBIOMOD was compared to existing biological modelling calculators for 15 sample cases. Results: Comparing RADBIOMOD to the existing biological modelling calculators, all models tested had mean absolute errors and root mean square errors less than 1%. Conclusions: RADBIOMOD produces results that are non-significantly different from existing biological modelling calculators for the models tested. It is hoped that this freely available, user-friendly program will aid future research into biological modelling.
KW - Biological modelling
KW - Normal tissue complication probability
KW - Radiotherapy plan evaluation
KW - Tumour control probability
UR - http://www.scopus.com/inward/record.url?scp=84948844802&partnerID=8YFLogxK
U2 - 10.1016/j.ejmp.2015.10.091
DO - 10.1016/j.ejmp.2015.10.091
M3 - Article
C2 - 26549777
AN - SCOPUS:84948844802
SN - 1120-1797
VL - 32
SP - 248
EP - 254
JO - Physica Medica
JF - Physica Medica
IS - 1
ER -