Quantitative linkage genome scan for atopy in a large collection of Caucasian families

B.T. Webb; E. Van Den Oord; A. Akkari; Steve Wilton; Tina Ly; R. Duff; K.C. Barnes; K. Carlsen; J. Gerritsen; W. Lenney; M. Silverman; P. Sly; J. Sundy; J. Tsanakas; A. Von Berg; M. Whyte; M. Blumenthal; J. Vestbo; L. Middleton; P.J. Helms; W.H. Anderson; S.G. Pillai

doi:10.1007/s00439-006-0285-z

Quantitative linkage genome scan for atopy in a large collection of Caucasian families

B.T. Webb, E. Van Den Oord, A. Akkari, Steve Wilton, Tina Ly, R. Duff, K.C. Barnes, K. Carlsen, J. Gerritsen, W. Lenney, M. Silverman, P. Sly, J. Sundy, J. Tsanakas, A. Von Berg, M. Whyte, M. Blumenthal, J. Vestbo, L. Middleton, P.J. HelmsW.H. Anderson, S.G. Pillai

Centre for Neuromuscular and Neurological Disorders (Perron Institute)
UWA Centre for Medical Research (affiliated with the Harry Perkins Institute of Medical Research)

Research output: Contribution to journal › Article › peer-review

13 Citations (Web of Science)

Abstract

Quantitative phenotypes correlated with a complex disorder offer increased power to detect linkage in comparison to affected-unaffected classifications. Asthma is a complex disorder characterized by periods of bronchial obstruction and increased bronchial hyper reactivity. In childhood and early adulthood, asthma is frequently associated also with quantitative measures of atopy. Genome wide quantitative multipoint linkage analysis was conducted for serum IgE levels and percentage of positive skin prick test (SPTper) using three large groups of families originally ascertained for asthma. In this report, 438 and 429 asthma families were informative for linkage using IgE and SPTper which represents 690 independent families. Suggestive linkage (LOD > 2) was found on chromosomes 1, 3, and 8q with maximum LODs of 2.34 (IgE), 2.03 (SPTper), and 2.25 (IgE) near markers D1S1653, D3S2322-D3S1764, and D8S2324, respectively. The results from chromosomes 1 and 3 replicate previous reports of linkage. We also replicate linkage to 5q with peak LODs of 1.96 (SPTper) and 1.77 (IgE) at or near marker D5S1480. Our results provide further evidence implicating chromosomes 1, 3, and 5q. The current report represents one of the biggest genome scans so far reported for asthma related phenotypes. This study also demonstrates the utility of increased sample sizes and quantitative phenotypes in linkage analysis of complex disorders.

Original language	English
Pages (from-to)	83-92
Journal	Human Genetics
Volume	121
Issue number	1
DOIs	https://doi.org/10.1007/s00439-006-0285-z
Publication status	Published - 2007

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Webb, B. T., Van Den Oord, E., Akkari, A., Wilton, S., Ly, T., Duff, R., Barnes, K. C., Carlsen, K., Gerritsen, J., Lenney, W., Silverman, M., Sly, P., Sundy, J., Tsanakas, J., Von Berg, A., Whyte, M., Blumenthal, M., Vestbo, J., Middleton, L., ... Pillai, S. G. (2007). Quantitative linkage genome scan for atopy in a large collection of Caucasian families. Human Genetics, 121(1), 83-92. https://doi.org/10.1007/s00439-006-0285-z

@article{4c1fe2854fe64a358f18a773671045e0,

title = "Quantitative linkage genome scan for atopy in a large collection of Caucasian families",

abstract = "Quantitative phenotypes correlated with a complex disorder offer increased power to detect linkage in comparison to affected-unaffected classifications. Asthma is a complex disorder characterized by periods of bronchial obstruction and increased bronchial hyper reactivity. In childhood and early adulthood, asthma is frequently associated also with quantitative measures of atopy. Genome wide quantitative multipoint linkage analysis was conducted for serum IgE levels and percentage of positive skin prick test (SPTper) using three large groups of families originally ascertained for asthma. In this report, 438 and 429 asthma families were informative for linkage using IgE and SPTper which represents 690 independent families. Suggestive linkage (LOD > 2) was found on chromosomes 1, 3, and 8q with maximum LODs of 2.34 (IgE), 2.03 (SPTper), and 2.25 (IgE) near markers D1S1653, D3S2322-D3S1764, and D8S2324, respectively. The results from chromosomes 1 and 3 replicate previous reports of linkage. We also replicate linkage to 5q with peak LODs of 1.96 (SPTper) and 1.77 (IgE) at or near marker D5S1480. Our results provide further evidence implicating chromosomes 1, 3, and 5q. The current report represents one of the biggest genome scans so far reported for asthma related phenotypes. This study also demonstrates the utility of increased sample sizes and quantitative phenotypes in linkage analysis of complex disorders.",

author = "B.T. Webb and {Van Den Oord}, E. and A. Akkari and Steve Wilton and Tina Ly and R. Duff and K.C. Barnes and K. Carlsen and J. Gerritsen and W. Lenney and M. Silverman and P. Sly and J. Sundy and J. Tsanakas and {Von Berg}, A. and M. Whyte and M. Blumenthal and J. Vestbo and L. Middleton and P.J. Helms and W.H. Anderson and S.G. Pillai",

year = "2007",

doi = "10.1007/s00439-006-0285-z",

language = "English",

volume = "121",

pages = "83--92",

journal = "Human Genetics",

issn = "0340-6717",

publisher = "Springer-Verlag London Ltd.",

number = "1",

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Webb, BT, Van Den Oord, E, Akkari, A, Wilton, S, Ly, T, Duff, R, Barnes, KC, Carlsen, K, Gerritsen, J, Lenney, W, Silverman, M, Sly, P, Sundy, J, Tsanakas, J, Von Berg, A, Whyte, M, Blumenthal, M, Vestbo, J, Middleton, L, Helms, PJ, Anderson, WH & Pillai, SG 2007, 'Quantitative linkage genome scan for atopy in a large collection of Caucasian families', Human Genetics, vol. 121, no. 1, pp. 83-92. https://doi.org/10.1007/s00439-006-0285-z

TY - JOUR

T1 - Quantitative linkage genome scan for atopy in a large collection of Caucasian families

AU - Webb, B.T.

AU - Van Den Oord, E.

AU - Akkari, A.

AU - Wilton, Steve

AU - Ly, Tina

AU - Duff, R.

AU - Barnes, K.C.

AU - Carlsen, K.

AU - Gerritsen, J.

AU - Lenney, W.

AU - Silverman, M.

AU - Sly, P.

AU - Sundy, J.

AU - Tsanakas, J.

AU - Von Berg, A.

AU - Whyte, M.

AU - Blumenthal, M.

AU - Vestbo, J.

AU - Middleton, L.

AU - Helms, P.J.

AU - Anderson, W.H.

AU - Pillai, S.G.

PY - 2007

Y1 - 2007

N2 - Quantitative phenotypes correlated with a complex disorder offer increased power to detect linkage in comparison to affected-unaffected classifications. Asthma is a complex disorder characterized by periods of bronchial obstruction and increased bronchial hyper reactivity. In childhood and early adulthood, asthma is frequently associated also with quantitative measures of atopy. Genome wide quantitative multipoint linkage analysis was conducted for serum IgE levels and percentage of positive skin prick test (SPTper) using three large groups of families originally ascertained for asthma. In this report, 438 and 429 asthma families were informative for linkage using IgE and SPTper which represents 690 independent families. Suggestive linkage (LOD > 2) was found on chromosomes 1, 3, and 8q with maximum LODs of 2.34 (IgE), 2.03 (SPTper), and 2.25 (IgE) near markers D1S1653, D3S2322-D3S1764, and D8S2324, respectively. The results from chromosomes 1 and 3 replicate previous reports of linkage. We also replicate linkage to 5q with peak LODs of 1.96 (SPTper) and 1.77 (IgE) at or near marker D5S1480. Our results provide further evidence implicating chromosomes 1, 3, and 5q. The current report represents one of the biggest genome scans so far reported for asthma related phenotypes. This study also demonstrates the utility of increased sample sizes and quantitative phenotypes in linkage analysis of complex disorders.

AB - Quantitative phenotypes correlated with a complex disorder offer increased power to detect linkage in comparison to affected-unaffected classifications. Asthma is a complex disorder characterized by periods of bronchial obstruction and increased bronchial hyper reactivity. In childhood and early adulthood, asthma is frequently associated also with quantitative measures of atopy. Genome wide quantitative multipoint linkage analysis was conducted for serum IgE levels and percentage of positive skin prick test (SPTper) using three large groups of families originally ascertained for asthma. In this report, 438 and 429 asthma families were informative for linkage using IgE and SPTper which represents 690 independent families. Suggestive linkage (LOD > 2) was found on chromosomes 1, 3, and 8q with maximum LODs of 2.34 (IgE), 2.03 (SPTper), and 2.25 (IgE) near markers D1S1653, D3S2322-D3S1764, and D8S2324, respectively. The results from chromosomes 1 and 3 replicate previous reports of linkage. We also replicate linkage to 5q with peak LODs of 1.96 (SPTper) and 1.77 (IgE) at or near marker D5S1480. Our results provide further evidence implicating chromosomes 1, 3, and 5q. The current report represents one of the biggest genome scans so far reported for asthma related phenotypes. This study also demonstrates the utility of increased sample sizes and quantitative phenotypes in linkage analysis of complex disorders.

U2 - 10.1007/s00439-006-0285-z

DO - 10.1007/s00439-006-0285-z

M3 - Article

C2 - 17103228

SN - 0340-6717

VL - 121

SP - 83

EP - 92

JO - Human Genetics

JF - Human Genetics

IS - 1

ER -

Quantitative linkage genome scan for atopy in a large collection of Caucasian families

Abstract

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