Abstract
Chest computed tomography (CT) is the gold standard for detecting structural lung disease in cystic fibrosis (CF), however there has been a lack of outcome measures appropriate for young children. In this project, a novel, quantitative measure of lung disease extent on CT - PRAGMA-CF - was developed. Outcomes from PRAGMA-CF were repeatable, associated with clinically relevant measures in children with CF, and feasible for use in research and clinical trials. This study provides both a rationale and a means to test interventions aimed at preventing structural lung disease in young children with CF.
Original language | English |
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Qualification | Doctor of Philosophy |
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Award date | 23 Nov 2017 |
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Publication status | Unpublished - 2017 |