Quantitative analysis of chest computed tomography in early cystic fibrosis lung disease

    Research output: ThesisDoctoral Thesis

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    Abstract

    Chest computed tomography (CT) is the gold standard for detecting structural lung disease in cystic fibrosis (CF), however there has been a lack of outcome measures appropriate for young children. In this project, a novel, quantitative measure of lung disease extent on CT - PRAGMA-CF - was developed. Outcomes from PRAGMA-CF were repeatable, associated with clinically relevant measures in children with CF, and feasible for use in research and clinical trials. This study provides both a rationale and a means to test interventions aimed at preventing structural lung disease in young children with CF.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • The University of Western Australia
    Thesis sponsors
    Award date23 Nov 2017
    DOIs
    Publication statusUnpublished - 2017

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