Chest computed tomography (CT) is the gold standard for detecting structural lung disease in cystic fibrosis (CF), however there has been a lack of outcome measures appropriate for young children. In this project, a novel, quantitative measure of lung disease extent on CT - PRAGMA-CF - was developed. Outcomes from PRAGMA-CF were repeatable, associated with clinically relevant measures in children with CF, and feasible for use in research and clinical trials. This study provides both a rationale and a means to test interventions aimed at preventing structural lung disease in young children with CF.
|Qualification||Doctor of Philosophy|
|Award date||23 Nov 2017|
|Publication status||Unpublished - 2017|