Quantification of Chondrocyte Morphology by Confocal Arthroscopy

C.W. Jones; D. Smolinski; J.P. Wu; Craig Willers; Karol Miller; Brett Kirk; Ming Zheng

doi:10.1142/S0218957704001314

Quantification of Chondrocyte Morphology by Confocal Arthroscopy

C.W. Jones, D. Smolinski, J.P. Wu, Craig Willers, Karol Miller, Brett Kirk, Ming Zheng

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

The purpose of this study was to determine the effectiveness of a novel Laser Scanning Confocal Arthroscope (LSCA) for the morphological quantification of articular cartilage chondrocytes.Healthy and debrided regions of the knee articular cartilage of six (6) New Zealand White rabbits were imaged during open follow-up surgery. Quantitative morphological analysis of chondrocyte cell populations was performed and compared to known parameters. Optical histology images were compared to conventional histology of similar sites.Optical histology revealed viable cells in normal hyaline cartilage tissue and enabled the visualization of fibro-cartilage in defect tissue. Morphological analysis was able to characterize the in vivo two-dimensional equivalent-area-diameter of chondrocytes. Significant differences (P

Original language	English
Pages (from-to)	145-154
Journal	Journal of Musculoskeletal Research
Volume	8
Issue number	4
DOIs	https://doi.org/10.1142/S0218957704001314
Publication status	Published - 2004

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title = "Quantification of Chondrocyte Morphology by Confocal Arthroscopy",

abstract = "The purpose of this study was to determine the effectiveness of a novel Laser Scanning Confocal Arthroscope (LSCA) for the morphological quantification of articular cartilage chondrocytes.Healthy and debrided regions of the knee articular cartilage of six (6) New Zealand White rabbits were imaged during open follow-up surgery. Quantitative morphological analysis of chondrocyte cell populations was performed and compared to known parameters. Optical histology images were compared to conventional histology of similar sites.Optical histology revealed viable cells in normal hyaline cartilage tissue and enabled the visualization of fibro-cartilage in defect tissue. Morphological analysis was able to characterize the in vivo two-dimensional equivalent-area-diameter of chondrocytes. Significant differences (P",

author = "C.W. Jones and D. Smolinski and J.P. Wu and Craig Willers and Karol Miller and Brett Kirk and Ming Zheng",

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T1 - Quantification of Chondrocyte Morphology by Confocal Arthroscopy

AU - Jones, C.W.

AU - Smolinski, D.

AU - Wu, J.P.

AU - Willers, Craig

AU - Miller, Karol

AU - Kirk, Brett

AU - Zheng, Ming

PY - 2004

Y1 - 2004

N2 - The purpose of this study was to determine the effectiveness of a novel Laser Scanning Confocal Arthroscope (LSCA) for the morphological quantification of articular cartilage chondrocytes.Healthy and debrided regions of the knee articular cartilage of six (6) New Zealand White rabbits were imaged during open follow-up surgery. Quantitative morphological analysis of chondrocyte cell populations was performed and compared to known parameters. Optical histology images were compared to conventional histology of similar sites.Optical histology revealed viable cells in normal hyaline cartilage tissue and enabled the visualization of fibro-cartilage in defect tissue. Morphological analysis was able to characterize the in vivo two-dimensional equivalent-area-diameter of chondrocytes. Significant differences (P

AB - The purpose of this study was to determine the effectiveness of a novel Laser Scanning Confocal Arthroscope (LSCA) for the morphological quantification of articular cartilage chondrocytes.Healthy and debrided regions of the knee articular cartilage of six (6) New Zealand White rabbits were imaged during open follow-up surgery. Quantitative morphological analysis of chondrocyte cell populations was performed and compared to known parameters. Optical histology images were compared to conventional histology of similar sites.Optical histology revealed viable cells in normal hyaline cartilage tissue and enabled the visualization of fibro-cartilage in defect tissue. Morphological analysis was able to characterize the in vivo two-dimensional equivalent-area-diameter of chondrocytes. Significant differences (P

U2 - 10.1142/S0218957704001314

DO - 10.1142/S0218957704001314

M3 - Article

SN - 0218-9577

VL - 8

SP - 145

EP - 154

JO - Journal of Musculoskeletal Research

JF - Journal of Musculoskeletal Research

IS - 4

ER -

Quantification of Chondrocyte Morphology by Confocal Arthroscopy

Abstract

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