Quantification of Chondrocyte Morphology by Confocal Arthroscopy

C.W. Jones, D. Smolinski, J.P. Wu, Craig Willers, Karol Miller, Brett Kirk, Ming Zheng

Research output: Contribution to journalArticle

9 Citations (Scopus)


The purpose of this study was to determine the effectiveness of a novel Laser Scanning Confocal Arthroscope (LSCA) for the morphological quantification of articular cartilage chondrocytes.Healthy and debrided regions of the knee articular cartilage of six (6) New Zealand White rabbits were imaged during open follow-up surgery. Quantitative morphological analysis of chondrocyte cell populations was performed and compared to known parameters. Optical histology images were compared to conventional histology of similar sites.Optical histology revealed viable cells in normal hyaline cartilage tissue and enabled the visualization of fibro-cartilage in defect tissue. Morphological analysis was able to characterize the in vivo two-dimensional equivalent-area-diameter of chondrocytes. Significant differences (P
Original languageEnglish
Pages (from-to)145-154
JournalJournal of Musculoskeletal Research
Issue number4
Publication statusPublished - 2004

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