Quality of life of women with lower limb swelling or lymphedema 3-5 years following endometrial cancer

I.J. Rowlands, V.L. Beesley, M. Janda, S.C. Hayes, A. Obermair, M.A. Quinn, A.H. Brand, Yee Leung, L. Mcquire, P.M. Webb

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    Abstract

    Objective: To quantitatively assess and compare the quality of life (QoL) of women with a self-reported diagnosis of lower limb lymphedema (LLL), to women with lower limb swelling (LLS), and to women without LLL or LLS following treatment for endometrial cancer. Methods: 1399 participants in the Australian National Endometrial Cancer Study were sent a follow-up questionnaire 3-5 years after diagnosis. Women were asked if they had experienced swelling in the lower limbs and, if so, whether they had received a diagnosis of lymphedema by a health professional. The 639 women who responded were categorized as: Women with LLL (n = 68), women with LLS (n = 177) and women without LLL or LLS (n = 394). Multivariable-adjusted generalized linear models were used to compare women's physical and mental QoL by LLL status. Results: On average, women were 65 years of age and 4 years after diagnosis. Women with LLL had clinically lower physical QoL (M = 41.8, SE = 1.4) than women without LLL or LLS (M = 45.1, SE = 0.8, p = .07), however, their mental QoL was within the normative range (M = 49.6; SE = 1.1 p = 1.0). Women with LLS had significantly lower physical (M = 41.0, SE = 1.0, p = .003) and mental QoL (M = 46.8; SE = 0.8, p < .0001) than women without LLL or LLS (Mental QoL: M = 50.6, SE = 0.8). Conclusion: Although LLL was associated with reductions in physical QoL, LLS was related to reductions in both physical and mental QoL 3–5 years after cancer treatment. Early referral to evidence-based lymphedema programs may prevent long-term impairments to women's QoL.
    Original languageEnglish
    Pages (from-to)314-318
    JournalGynecologic Oncology
    Volume133
    Issue number2
    Early online date11 Mar 2014
    DOIs
    Publication statusPublished - May 2014

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    Lymphedema
    Endometrial Neoplasms
    Lower Extremity
    Quality of Life

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    Rowlands, I. J., Beesley, V. L., Janda, M., Hayes, S. C., Obermair, A., Quinn, M. A., ... Webb, P. M. (2014). Quality of life of women with lower limb swelling or lymphedema 3-5 years following endometrial cancer. Gynecologic Oncology, 133(2), 314-318. https://doi.org/10.1016/j.ygyno.2014.03.003
    Rowlands, I.J. ; Beesley, V.L. ; Janda, M. ; Hayes, S.C. ; Obermair, A. ; Quinn, M.A. ; Brand, A.H. ; Leung, Yee ; Mcquire, L. ; Webb, P.M. / Quality of life of women with lower limb swelling or lymphedema 3-5 years following endometrial cancer. In: Gynecologic Oncology. 2014 ; Vol. 133, No. 2. pp. 314-318.
    @article{18a6859cbe3145c8805aa8c98a5ae391,
    title = "Quality of life of women with lower limb swelling or lymphedema 3-5 years following endometrial cancer",
    abstract = "Objective: To quantitatively assess and compare the quality of life (QoL) of women with a self-reported diagnosis of lower limb lymphedema (LLL), to women with lower limb swelling (LLS), and to women without LLL or LLS following treatment for endometrial cancer. Methods: 1399 participants in the Australian National Endometrial Cancer Study were sent a follow-up questionnaire 3-5 years after diagnosis. Women were asked if they had experienced swelling in the lower limbs and, if so, whether they had received a diagnosis of lymphedema by a health professional. The 639 women who responded were categorized as: Women with LLL (n = 68), women with LLS (n = 177) and women without LLL or LLS (n = 394). Multivariable-adjusted generalized linear models were used to compare women's physical and mental QoL by LLL status. Results: On average, women were 65 years of age and 4 years after diagnosis. Women with LLL had clinically lower physical QoL (M = 41.8, SE = 1.4) than women without LLL or LLS (M = 45.1, SE = 0.8, p = .07), however, their mental QoL was within the normative range (M = 49.6; SE = 1.1 p = 1.0). Women with LLS had significantly lower physical (M = 41.0, SE = 1.0, p = .003) and mental QoL (M = 46.8; SE = 0.8, p < .0001) than women without LLL or LLS (Mental QoL: M = 50.6, SE = 0.8). Conclusion: Although LLL was associated with reductions in physical QoL, LLS was related to reductions in both physical and mental QoL 3–5 years after cancer treatment. Early referral to evidence-based lymphedema programs may prevent long-term impairments to women's QoL.",
    author = "I.J. Rowlands and V.L. Beesley and M. Janda and S.C. Hayes and A. Obermair and M.A. Quinn and A.H. Brand and Yee Leung and L. Mcquire and P.M. Webb",
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    Rowlands, IJ, Beesley, VL, Janda, M, Hayes, SC, Obermair, A, Quinn, MA, Brand, AH, Leung, Y, Mcquire, L & Webb, PM 2014, 'Quality of life of women with lower limb swelling or lymphedema 3-5 years following endometrial cancer' Gynecologic Oncology, vol. 133, no. 2, pp. 314-318. https://doi.org/10.1016/j.ygyno.2014.03.003

    Quality of life of women with lower limb swelling or lymphedema 3-5 years following endometrial cancer. / Rowlands, I.J.; Beesley, V.L.; Janda, M.; Hayes, S.C.; Obermair, A.; Quinn, M.A.; Brand, A.H.; Leung, Yee; Mcquire, L.; Webb, P.M.

    In: Gynecologic Oncology, Vol. 133, No. 2, 05.2014, p. 314-318.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Quality of life of women with lower limb swelling or lymphedema 3-5 years following endometrial cancer

    AU - Rowlands, I.J.

    AU - Beesley, V.L.

    AU - Janda, M.

    AU - Hayes, S.C.

    AU - Obermair, A.

    AU - Quinn, M.A.

    AU - Brand, A.H.

    AU - Leung, Yee

    AU - Mcquire, L.

    AU - Webb, P.M.

    PY - 2014/5

    Y1 - 2014/5

    N2 - Objective: To quantitatively assess and compare the quality of life (QoL) of women with a self-reported diagnosis of lower limb lymphedema (LLL), to women with lower limb swelling (LLS), and to women without LLL or LLS following treatment for endometrial cancer. Methods: 1399 participants in the Australian National Endometrial Cancer Study were sent a follow-up questionnaire 3-5 years after diagnosis. Women were asked if they had experienced swelling in the lower limbs and, if so, whether they had received a diagnosis of lymphedema by a health professional. The 639 women who responded were categorized as: Women with LLL (n = 68), women with LLS (n = 177) and women without LLL or LLS (n = 394). Multivariable-adjusted generalized linear models were used to compare women's physical and mental QoL by LLL status. Results: On average, women were 65 years of age and 4 years after diagnosis. Women with LLL had clinically lower physical QoL (M = 41.8, SE = 1.4) than women without LLL or LLS (M = 45.1, SE = 0.8, p = .07), however, their mental QoL was within the normative range (M = 49.6; SE = 1.1 p = 1.0). Women with LLS had significantly lower physical (M = 41.0, SE = 1.0, p = .003) and mental QoL (M = 46.8; SE = 0.8, p < .0001) than women without LLL or LLS (Mental QoL: M = 50.6, SE = 0.8). Conclusion: Although LLL was associated with reductions in physical QoL, LLS was related to reductions in both physical and mental QoL 3–5 years after cancer treatment. Early referral to evidence-based lymphedema programs may prevent long-term impairments to women's QoL.

    AB - Objective: To quantitatively assess and compare the quality of life (QoL) of women with a self-reported diagnosis of lower limb lymphedema (LLL), to women with lower limb swelling (LLS), and to women without LLL or LLS following treatment for endometrial cancer. Methods: 1399 participants in the Australian National Endometrial Cancer Study were sent a follow-up questionnaire 3-5 years after diagnosis. Women were asked if they had experienced swelling in the lower limbs and, if so, whether they had received a diagnosis of lymphedema by a health professional. The 639 women who responded were categorized as: Women with LLL (n = 68), women with LLS (n = 177) and women without LLL or LLS (n = 394). Multivariable-adjusted generalized linear models were used to compare women's physical and mental QoL by LLL status. Results: On average, women were 65 years of age and 4 years after diagnosis. Women with LLL had clinically lower physical QoL (M = 41.8, SE = 1.4) than women without LLL or LLS (M = 45.1, SE = 0.8, p = .07), however, their mental QoL was within the normative range (M = 49.6; SE = 1.1 p = 1.0). Women with LLS had significantly lower physical (M = 41.0, SE = 1.0, p = .003) and mental QoL (M = 46.8; SE = 0.8, p < .0001) than women without LLL or LLS (Mental QoL: M = 50.6, SE = 0.8). Conclusion: Although LLL was associated with reductions in physical QoL, LLS was related to reductions in both physical and mental QoL 3–5 years after cancer treatment. Early referral to evidence-based lymphedema programs may prevent long-term impairments to women's QoL.

    U2 - 10.1016/j.ygyno.2014.03.003

    DO - 10.1016/j.ygyno.2014.03.003

    M3 - Article

    VL - 133

    SP - 314

    EP - 318

    JO - Gynecologic Oncology

    JF - Gynecologic Oncology

    SN - 0090-8258

    IS - 2

    ER -