QTc prolongation in schizophrenia patients in Asia: Clinical correlates and trends between 2004 and 2008/2009

Y. Xiang, H.F.K. Chiu, Gabor Ungvári, C.U. Correll, K.Y.C. Lai, C. Wang, T. Si, E. Lee, Y. He, S. Yang, M. Chong, E. Kua, S. Fujii, K. Sim, M.K.H. Yong, J.K. Trivedi, E. Chung, P. Udomratn, K. Chee, N. Sartorius & 2 others C. Tan, N. Shinfuku

    Research output: Contribution to journalArticle

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    Abstract

    Copyright © 2015 John Wiley & Sons, Ltd. Copyright © 2015 John Wiley & Sons, Ltd. Objective Little is known about the pattern of QT interval (QTc) prolongation in Asian patients with schizophrenia. This study examined trends of QTc prolongation in schizophrenia inpatients in six Asian countries and territories between 2004 and 2008/2009 and its independent demographic and clinical correlates. Method Data on 3482 hospitalized schizophrenia patients (2004 = 1826 and 2008/2009 = 1656) in six Asian countries and territories were collected by either chart review or interviews during a 1-month period. Patients' sociodemographic and clinical characteristics, prescriptions of psychotropic drugs, and QTc interval were recorded using a standardized protocol and data collection procedure. Results The frequency of QTc prolongation (>456 ms) was 2.4% in the whole sample, decreasing from 3.1% in 2004 to 1.6% in 2008/2009 (p = 0.004) with wide intercountry variations. However, this decreased trend was driven by decreased QTc prolongation detected in China and Hong Kong (both p-values <0.05). Multiple logistic regression analysis of the whole sample revealed that patients having more likely to have an illness lasting longer than 5 years and received antipsychotics classified as list-1 drugs according to the Arizona Centre for Education and Research on Therapeutics. Compared with 2004, patients in 2008/2009 were less likely to have QTc prolongation. Thioridazine caused QTc prolongation most frequently (odds ratio (OR) 4.4; 95% confidence interval (CI) 1.2-15.2), followed by sulpiride (OR 2.4; 95% CI 1.3-4.5), clozapine (OR 2.4; 95% CI 1.4-4.2), and chlorpromazine (OR 1.9; 95% CI 1.07-3.5). Conclusions Frequency of QTc prolongation was low in Asian patients with schizophrenia. QTc prolongation in schizophrenia decreased in China and Hong Kong between 2004 and 2008/2009 but increased in Taiwan over the same period, remaining low in the other countries.
    Original languageEnglish
    Pages (from-to)94-99
    JournalHuman Psychopharmacology
    Volume30
    Issue number2
    DOIs
    Publication statusPublished - 2015

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    Schizophrenia
    Odds Ratio
    Confidence Intervals
    Hong Kong
    Nuclear Family
    China
    Therapeutic Human Experimentation
    Thioridazine
    Sulpiride
    Prescription Drugs
    Clozapine
    Psychotropic Drugs
    Chlorpromazine
    Taiwan
    Antipsychotic Agents
    Inpatients
    Logistic Models
    Regression Analysis
    Demography
    Interviews

    Cite this

    Xiang, Y. ; Chiu, H.F.K. ; Ungvári, Gabor ; Correll, C.U. ; Lai, K.Y.C. ; Wang, C. ; Si, T. ; Lee, E. ; He, Y. ; Yang, S. ; Chong, M. ; Kua, E. ; Fujii, S. ; Sim, K. ; Yong, M.K.H. ; Trivedi, J.K. ; Chung, E. ; Udomratn, P. ; Chee, K. ; Sartorius, N. ; Tan, C. ; Shinfuku, N. / QTc prolongation in schizophrenia patients in Asia: Clinical correlates and trends between 2004 and 2008/2009. In: Human Psychopharmacology. 2015 ; Vol. 30, No. 2. pp. 94-99.
    @article{f6626033d41643c592946073a29a82d6,
    title = "QTc prolongation in schizophrenia patients in Asia: Clinical correlates and trends between 2004 and 2008/2009",
    abstract = "Copyright {\circledC} 2015 John Wiley & Sons, Ltd. Copyright {\circledC} 2015 John Wiley & Sons, Ltd. Objective Little is known about the pattern of QT interval (QTc) prolongation in Asian patients with schizophrenia. This study examined trends of QTc prolongation in schizophrenia inpatients in six Asian countries and territories between 2004 and 2008/2009 and its independent demographic and clinical correlates. Method Data on 3482 hospitalized schizophrenia patients (2004 = 1826 and 2008/2009 = 1656) in six Asian countries and territories were collected by either chart review or interviews during a 1-month period. Patients' sociodemographic and clinical characteristics, prescriptions of psychotropic drugs, and QTc interval were recorded using a standardized protocol and data collection procedure. Results The frequency of QTc prolongation (>456 ms) was 2.4{\%} in the whole sample, decreasing from 3.1{\%} in 2004 to 1.6{\%} in 2008/2009 (p = 0.004) with wide intercountry variations. However, this decreased trend was driven by decreased QTc prolongation detected in China and Hong Kong (both p-values <0.05). Multiple logistic regression analysis of the whole sample revealed that patients having more likely to have an illness lasting longer than 5 years and received antipsychotics classified as list-1 drugs according to the Arizona Centre for Education and Research on Therapeutics. Compared with 2004, patients in 2008/2009 were less likely to have QTc prolongation. Thioridazine caused QTc prolongation most frequently (odds ratio (OR) 4.4; 95{\%} confidence interval (CI) 1.2-15.2), followed by sulpiride (OR 2.4; 95{\%} CI 1.3-4.5), clozapine (OR 2.4; 95{\%} CI 1.4-4.2), and chlorpromazine (OR 1.9; 95{\%} CI 1.07-3.5). Conclusions Frequency of QTc prolongation was low in Asian patients with schizophrenia. QTc prolongation in schizophrenia decreased in China and Hong Kong between 2004 and 2008/2009 but increased in Taiwan over the same period, remaining low in the other countries.",
    author = "Y. Xiang and H.F.K. Chiu and Gabor Ungv{\'a}ri and C.U. Correll and K.Y.C. Lai and C. Wang and T. Si and E. Lee and Y. He and S. Yang and M. Chong and E. Kua and S. Fujii and K. Sim and M.K.H. Yong and J.K. Trivedi and E. Chung and P. Udomratn and K. Chee and N. Sartorius and C. Tan and N. Shinfuku",
    year = "2015",
    doi = "10.1002/hup.2458",
    language = "English",
    volume = "30",
    pages = "94--99",
    journal = "Human Psychopharmacology: Clinical and Experimental",
    issn = "0885-6222",
    publisher = "John Wiley & Sons",
    number = "2",

    }

    Xiang, Y, Chiu, HFK, Ungvári, G, Correll, CU, Lai, KYC, Wang, C, Si, T, Lee, E, He, Y, Yang, S, Chong, M, Kua, E, Fujii, S, Sim, K, Yong, MKH, Trivedi, JK, Chung, E, Udomratn, P, Chee, K, Sartorius, N, Tan, C & Shinfuku, N 2015, 'QTc prolongation in schizophrenia patients in Asia: Clinical correlates and trends between 2004 and 2008/2009' Human Psychopharmacology, vol. 30, no. 2, pp. 94-99. https://doi.org/10.1002/hup.2458

    QTc prolongation in schizophrenia patients in Asia: Clinical correlates and trends between 2004 and 2008/2009. / Xiang, Y.; Chiu, H.F.K.; Ungvári, Gabor; Correll, C.U.; Lai, K.Y.C.; Wang, C.; Si, T.; Lee, E.; He, Y.; Yang, S.; Chong, M.; Kua, E.; Fujii, S.; Sim, K.; Yong, M.K.H.; Trivedi, J.K.; Chung, E.; Udomratn, P.; Chee, K.; Sartorius, N.; Tan, C.; Shinfuku, N.

    In: Human Psychopharmacology, Vol. 30, No. 2, 2015, p. 94-99.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - QTc prolongation in schizophrenia patients in Asia: Clinical correlates and trends between 2004 and 2008/2009

    AU - Xiang, Y.

    AU - Chiu, H.F.K.

    AU - Ungvári, Gabor

    AU - Correll, C.U.

    AU - Lai, K.Y.C.

    AU - Wang, C.

    AU - Si, T.

    AU - Lee, E.

    AU - He, Y.

    AU - Yang, S.

    AU - Chong, M.

    AU - Kua, E.

    AU - Fujii, S.

    AU - Sim, K.

    AU - Yong, M.K.H.

    AU - Trivedi, J.K.

    AU - Chung, E.

    AU - Udomratn, P.

    AU - Chee, K.

    AU - Sartorius, N.

    AU - Tan, C.

    AU - Shinfuku, N.

    PY - 2015

    Y1 - 2015

    N2 - Copyright © 2015 John Wiley & Sons, Ltd. Copyright © 2015 John Wiley & Sons, Ltd. Objective Little is known about the pattern of QT interval (QTc) prolongation in Asian patients with schizophrenia. This study examined trends of QTc prolongation in schizophrenia inpatients in six Asian countries and territories between 2004 and 2008/2009 and its independent demographic and clinical correlates. Method Data on 3482 hospitalized schizophrenia patients (2004 = 1826 and 2008/2009 = 1656) in six Asian countries and territories were collected by either chart review or interviews during a 1-month period. Patients' sociodemographic and clinical characteristics, prescriptions of psychotropic drugs, and QTc interval were recorded using a standardized protocol and data collection procedure. Results The frequency of QTc prolongation (>456 ms) was 2.4% in the whole sample, decreasing from 3.1% in 2004 to 1.6% in 2008/2009 (p = 0.004) with wide intercountry variations. However, this decreased trend was driven by decreased QTc prolongation detected in China and Hong Kong (both p-values <0.05). Multiple logistic regression analysis of the whole sample revealed that patients having more likely to have an illness lasting longer than 5 years and received antipsychotics classified as list-1 drugs according to the Arizona Centre for Education and Research on Therapeutics. Compared with 2004, patients in 2008/2009 were less likely to have QTc prolongation. Thioridazine caused QTc prolongation most frequently (odds ratio (OR) 4.4; 95% confidence interval (CI) 1.2-15.2), followed by sulpiride (OR 2.4; 95% CI 1.3-4.5), clozapine (OR 2.4; 95% CI 1.4-4.2), and chlorpromazine (OR 1.9; 95% CI 1.07-3.5). Conclusions Frequency of QTc prolongation was low in Asian patients with schizophrenia. QTc prolongation in schizophrenia decreased in China and Hong Kong between 2004 and 2008/2009 but increased in Taiwan over the same period, remaining low in the other countries.

    AB - Copyright © 2015 John Wiley & Sons, Ltd. Copyright © 2015 John Wiley & Sons, Ltd. Objective Little is known about the pattern of QT interval (QTc) prolongation in Asian patients with schizophrenia. This study examined trends of QTc prolongation in schizophrenia inpatients in six Asian countries and territories between 2004 and 2008/2009 and its independent demographic and clinical correlates. Method Data on 3482 hospitalized schizophrenia patients (2004 = 1826 and 2008/2009 = 1656) in six Asian countries and territories were collected by either chart review or interviews during a 1-month period. Patients' sociodemographic and clinical characteristics, prescriptions of psychotropic drugs, and QTc interval were recorded using a standardized protocol and data collection procedure. Results The frequency of QTc prolongation (>456 ms) was 2.4% in the whole sample, decreasing from 3.1% in 2004 to 1.6% in 2008/2009 (p = 0.004) with wide intercountry variations. However, this decreased trend was driven by decreased QTc prolongation detected in China and Hong Kong (both p-values <0.05). Multiple logistic regression analysis of the whole sample revealed that patients having more likely to have an illness lasting longer than 5 years and received antipsychotics classified as list-1 drugs according to the Arizona Centre for Education and Research on Therapeutics. Compared with 2004, patients in 2008/2009 were less likely to have QTc prolongation. Thioridazine caused QTc prolongation most frequently (odds ratio (OR) 4.4; 95% confidence interval (CI) 1.2-15.2), followed by sulpiride (OR 2.4; 95% CI 1.3-4.5), clozapine (OR 2.4; 95% CI 1.4-4.2), and chlorpromazine (OR 1.9; 95% CI 1.07-3.5). Conclusions Frequency of QTc prolongation was low in Asian patients with schizophrenia. QTc prolongation in schizophrenia decreased in China and Hong Kong between 2004 and 2008/2009 but increased in Taiwan over the same period, remaining low in the other countries.

    U2 - 10.1002/hup.2458

    DO - 10.1002/hup.2458

    M3 - Article

    VL - 30

    SP - 94

    EP - 99

    JO - Human Psychopharmacology: Clinical and Experimental

    JF - Human Psychopharmacology: Clinical and Experimental

    SN - 0885-6222

    IS - 2

    ER -