QSAR Modeling of Carbonic Anhydrase-I, -II and -IV Inhibitory Activities: Relative Correlation Potential of Six Topological Indices

P.V. Khadikar; B.W. Clare; A.T. Balaban; C.T. Supuran; V.K. Agarwal; J. Singh; A.K. Joshi; M. Lakhwami

QSAR Modeling of Carbonic Anhydrase-I, -II and -IV Inhibitory Activities: Relative Correlation Potential of Six Topological Indices

P.V. Khadikar, B.W. Clare, A.T. Balaban, C.T. Supuran, V.K. Agarwal, J. Singh, A.K. Joshi, M. Lakhwami

School of Molecular Sciences

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

QSAR studies on modeling the biological activities of 26 benzenesulfonamide derivatives as inhibitors of carbonic anhydrases CA-I, CA-II and CA-IV were performed using six distance-based topological indices, including Balaban-type indices J(hetV) and J(hetE). Satisfactory multiparametric correlations were obtained.

Original language	English
Pages (from-to)	703-717
Journal	Revue Roumaine de Chimie
Volume	51
Publication status	Published - 2006

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title = "QSAR Modeling of Carbonic Anhydrase-I, -II and -IV Inhibitory Activities: Relative Correlation Potential of Six Topological Indices",

abstract = "QSAR studies on modeling the biological activities of 26 benzenesulfonamide derivatives as inhibitors of carbonic anhydrases CA-I, CA-II and CA-IV were performed using six distance-based topological indices, including Balaban-type indices J(hetV) and J(hetE). Satisfactory multiparametric correlations were obtained.",

author = "P.V. Khadikar and B.W. Clare and A.T. Balaban and C.T. Supuran and V.K. Agarwal and J. Singh and A.K. Joshi and M. Lakhwami",

year = "2006",

language = "English",

volume = "51",

pages = "703--717",

journal = "Revue Roumaine de Chimie",

issn = "0035-3930",

publisher = "Editions de l'Academie Republique Populaire",

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TY - JOUR

T1 - QSAR Modeling of Carbonic Anhydrase-I, -II and -IV Inhibitory Activities: Relative Correlation Potential of Six Topological Indices

AU - Khadikar, P.V.

AU - Clare, B.W.

AU - Balaban, A.T.

AU - Supuran, C.T.

AU - Agarwal, V.K.

AU - Singh, J.

AU - Joshi, A.K.

AU - Lakhwami, M.

PY - 2006

Y1 - 2006

N2 - QSAR studies on modeling the biological activities of 26 benzenesulfonamide derivatives as inhibitors of carbonic anhydrases CA-I, CA-II and CA-IV were performed using six distance-based topological indices, including Balaban-type indices J(hetV) and J(hetE). Satisfactory multiparametric correlations were obtained.

AB - QSAR studies on modeling the biological activities of 26 benzenesulfonamide derivatives as inhibitors of carbonic anhydrases CA-I, CA-II and CA-IV were performed using six distance-based topological indices, including Balaban-type indices J(hetV) and J(hetE). Satisfactory multiparametric correlations were obtained.

M3 - Article

SN - 0035-3930

VL - 51

SP - 703

EP - 717

JO - Revue Roumaine de Chimie

JF - Revue Roumaine de Chimie

ER -

QSAR Modeling of Carbonic Anhydrase-I, -II and -IV Inhibitory Activities: Relative Correlation Potential of Six Topological Indices

Abstract

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