Pyrrhocoricin as a potential drug delivery vehicle for Cryptosporidium parvum

A. Boxell, S.H.C. Lee, R. Jefferies, Paul Watt, R. Hopkins, S. Reid, A. Armson, U. Ryan

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

This study analysed the intracellular delivery capacity of insect derived pyrrhocoricin with a peptide cargo in Cryptosporidium parvum in vitro using fluorescence microscopy. Results revealed that pyrrhocoricin was capable of acting as a delivery vehicle in transducing peptides across the parasite cell membrane for multiple life-cycle stages. The successful transduction may aid in target validation and the delivery of future peptide-based drugs against this important human pathogen.
Original languageEnglish
Pages (from-to)301-303
JournalExperimental Parasitology
Volume119
Issue number2
DOIs
Publication statusPublished - 2008

Fingerprint

Dive into the research topics of 'Pyrrhocoricin as a potential drug delivery vehicle for Cryptosporidium parvum'. Together they form a unique fingerprint.

Cite this