Puberty suppression in transgender children and adolescents

Simone Mahfouda, Julia K. Moore, Aris Siafarikas, Florian D. Zepf, Ashleigh Lin

Research output: Contribution to journalReview articlepeer-review

77 Citations (Scopus)


The World Professional Association for Transgender Health's standards of care recommend suspending puberty, preferably with the use of gonadotropin-releasing hormone agonists, in certain gender non-conforming minors (aged under 18 years) who have undergone a psychiatric assessment and have reached at least Tanner stage II of puberty. This approach seeks to lessen the discordance between assigned natal sex and gender identity by temporarily halting the development of secondary sexual characteristics, essentially widening the temporal window for gender clarification. Despite promising preliminary evidence on the clinical utility of this approach, there is a dearth of research to inform evidence-based practice. In view of these challenges, we review the available empirical evidence on the cognitive, physical, and surgical implications of puberty suppression in gender-incongruent children and adolescents. We also explore the historical underpinnings and clinical impetus for suspending puberty in this population, and propose key research priorities.

Original languageEnglish
Pages (from-to)816-826
Number of pages11
JournalThe Lancet Diabetes and Endocrinology
Issue number10
Publication statusPublished - Oct 2017


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