Psychosocial impact of undergoing prostate cancer screening for men with BRCA1 or BRCA2 mutations

IMPACT Study Steering Comm, IMPACT Collaborators

Research output: Contribution to journalArticle

Abstract

Objectives To report the baseline results of a longitudinal psychosocial study that forms part of the IMPACT study, a multi-national investigation of targeted prostate cancer (PCa) screening among men with a known pathogenic germline mutation in the BRCA1 or BRCA2 genes. Particpants and Methods Men enrolled in the IMPACT study were invited to complete a questionnaire at collaborating sites prior to each annual screening visit. The questionnaire included sociodemographic characteristics and the following measures: the Hospital Anxiety and Depression Scale (HADS), Impact of Event Scale (IES), 36-item short-form health survey (SF-36), Memorial Anxiety Scale for Prostate Cancer, Cancer Worry Scale-Revised, risk perception and knowledge. The results of the baseline questionnaire are presented. Results A total of 432 men completed questionnaires: 98 and 160 had mutations in BRCA1 and BRCA2 genes, respectively, and 174 were controls (familial mutation negative). Participants' perception of PCa risk was influenced by genetic status. Knowledge levels were high and unrelated to genetic status. Mean scores for the HADS and SF-36 were within reported general population norms and mean IES scores were within normal range. IES mean intrusion and avoidance scores were significantly higher in BRCA1/BRCA2 carriers than in controls and were higher in men with increased PCa risk perception. At the multivariate level, risk perception contributed more significantly to variance in IES scores than genetic status. Conclusion This is the first study to report the psychosocial profile of men with BRCA1/BRCA2 mutations undergoing PCa screening. No clinically concerning levels of general or cancer-specific distress or poor quality of life were detected in the cohort as a whole. A small subset of participants reported higher levels of distress, suggesting the need for healthcare professionals offering PCa screening to identify these risk factors and offer additional information and support to men seeking PCa screening.

Original languageEnglish
Pages (from-to)284-292
Number of pages9
JournalBJU International
Volume123
Issue number2
DOIs
Publication statusPublished - Feb 2019

Cite this

IMPACT Study Steering Comm ; IMPACT Collaborators. / Psychosocial impact of undergoing prostate cancer screening for men with BRCA1 or BRCA2 mutations. In: BJU International. 2019 ; Vol. 123, No. 2. pp. 284-292.
@article{8fa9b3e0d1bb4d708e2fcd857b9d086a,
title = "Psychosocial impact of undergoing prostate cancer screening for men with BRCA1 or BRCA2 mutations",
abstract = "Objectives To report the baseline results of a longitudinal psychosocial study that forms part of the IMPACT study, a multi-national investigation of targeted prostate cancer (PCa) screening among men with a known pathogenic germline mutation in the BRCA1 or BRCA2 genes. Particpants and Methods Men enrolled in the IMPACT study were invited to complete a questionnaire at collaborating sites prior to each annual screening visit. The questionnaire included sociodemographic characteristics and the following measures: the Hospital Anxiety and Depression Scale (HADS), Impact of Event Scale (IES), 36-item short-form health survey (SF-36), Memorial Anxiety Scale for Prostate Cancer, Cancer Worry Scale-Revised, risk perception and knowledge. The results of the baseline questionnaire are presented. Results A total of 432 men completed questionnaires: 98 and 160 had mutations in BRCA1 and BRCA2 genes, respectively, and 174 were controls (familial mutation negative). Participants' perception of PCa risk was influenced by genetic status. Knowledge levels were high and unrelated to genetic status. Mean scores for the HADS and SF-36 were within reported general population norms and mean IES scores were within normal range. IES mean intrusion and avoidance scores were significantly higher in BRCA1/BRCA2 carriers than in controls and were higher in men with increased PCa risk perception. At the multivariate level, risk perception contributed more significantly to variance in IES scores than genetic status. Conclusion This is the first study to report the psychosocial profile of men with BRCA1/BRCA2 mutations undergoing PCa screening. No clinically concerning levels of general or cancer-specific distress or poor quality of life were detected in the cohort as a whole. A small subset of participants reported higher levels of distress, suggesting the need for healthcare professionals offering PCa screening to identify these risk factors and offer additional information and support to men seeking PCa screening.",
keywords = "#pcsm, #ProstateCancer, BRCA1, BRCA2, psychosocial, quality of life, QUALITY-OF-LIFE, FAMILY-HISTORY, PSYCHOLOGICAL IMPACT, HOSPITAL ANXIETY, RISK PERCEPTION, OVARIAN-CANCER, BRCA1/2, HEALTH, POPULATION, PSA",
author = "{IMPACT Study Steering Comm} and {IMPACT Collaborators} and Bancroft, {Elizabeth K.} and Sibel Saya and Page, {Elizabeth C.} and Kathryn Myhill and Sarah Thomas and Jennifer Pope and Anthony Chamberlain and Rachel Hart and Wayne Glover and Jackie Cook and Rosario, {Derek J.} and Helfand, {Brian T.} and Selkirk, {Christina Hutten} and Rosemarie Davidson and Mark Longmuir and Diana Eccles and Neus Gadea and Carole Brewer and Julian Barwell and Monica Salinas and Lynn Greenhalgh and Marc Tischkowitz and Alex Henderson and Evans, {David Gareth} and Saundra Buys and Eeles, {Rosalind A.} and Aaronson, {Neil K.} and Rosalind Eeles and Elizabeth Page and Zsofia Kote-Jarai and Audrey Ardern-Jones and Chris Bangma and Elena Castro and David Dearnaley and Alison Falconer and Christopher Foster and Henrik Gronberg and Hamdy, {Freddie C.} and Johannsson, {Oskar Thor} and Vincent Khoo and Diana Eccles and Hans Lilja and Gareth Evans and Jorunn Eyfjord and Jan Lubinski and Lovise Maehle and Christos Mikropoulos and Alan Millner and Anita Mitra and Judith Offman and Clare Moynihan and Gad Rennert and Mohnish Suri and Alex Dias and Natalie Taylor and Lucia D'Mello and Jenny Pope and Paul James and Gillian Mitchell and Sue Shanley and Kate Richardson and Joanne McKinley and Lara Petelin and Morgan Murphy and Lyon Mascarenhas and Declan Murphy and Jimmy Lam and Louise Taylor and Cathy Miller and Alan Stapleton and Michael Chong and Graeme Suthers and Nicola Poplawski and Katherine Tucker and Lesley Andrews and Jessica Duffy and Richard Millard and Robyn Ward and Rachel Williams and Phillip Stricker and Judy Kirk and Michelle Bowman and Manish Patel and Marion Harris and Shona O'Connell and Clare Hunt and Courtney Smyth and Mark Frydenberg and Geoffrey Lindeman and Kylie Shackleton and Catherine Morton and Rachel Susman and Julie McGaughran and Melanie Boon and Nicholas Pachter and Sharron Townshend and Lyn Schofield and Cassandra Nicholls and Allan Spigelman and Margaret Gleeson and David Amor and Jo Burke and Briony Patterson and Peter Swindle and Rodney Scott and William Foulkes and Talia Boshari and Armen Aprikian and Thomas Jensen and Anders Bojeson and Palle Osther and Anne-Bine Skytte and Dorthe Cruger and Tondering, {Majbritt Kure} and Anne-Marie Gerdes and Rita Schmutzler and Kerstin Rhiem and Petra Wihler and K. Kast and C. Griebsch and Oskar Johannsson and Vigdis Stefansdottir and Vedang Murthy and Rajiv Sarin and Kasturi Awatagiri and Sujata Ghonge and Pradnya Kowtal and Gouri Mulgund and David Gallagher and Richard Bambury and Michael Farrell and Fergal Gallagher and Ingrid Kiernan and Eitan Friedman and Rakefet Chen-Shtoyerman and Alon Basevitch and Dan Leibovici and Ehud Melzer and Ben-Yehoshua, {Sagi Josefsberg} and Nicola Nicolai and Paolo Radice and Riccardo Valdagni and Tiziana Magnani and Simona Gay and Teo, {Soo Hwang} and Tan, {Hui Meng} and Sook-Yee Yoon and Thong, {Meow Keong} and Hans Vasen and Janneke Ringleberg and {van Asperen}, Christi and Bart Kiemeney and {van Zelst-Stams}, Wendy and Ausems, {Margreet G. E. M.} and {van der Luijt}, {Rob B.} and {van Os}, Theo and Ruijs, {Marielle W. G.} and Adank, {Muriel A.} and Oldenburg, {Rogier A.} and {Helderman-van den Enden}, {A. Paula T. J. M.} and Caanen, {B. A. H.} and Oosterwijk, {Jan C.} and Pal Moller and Bjorn Brennhovd and Heidi Medvik and Eldbjorg Hanslien and Grindedal, {Eli Marie} and Cezary Cybulski and Dominika Wokolorczyk and Manuel Teixeira and Sofia Maia and Ana Peixoto and Rui Henrique and Jorge Oliveira and Nuno Goncalves and Luis Araujo and Manuela Seixas and Souto, {Joao Paulo} and Pedro Nogueira and Lucia Copakova and Janez Zgajnar and Mateja Krajc and Alenka Vrecar and Gabriel Capella and {Ramon y Cajal}, Teresa and David Fisas and Josefina Mora and Salvador Esquena and Judith Balmana and Juan Morote and Annelie Liljegren and Marie Hjalm-Eriksson and Karl-Johan Ekdahl and Stefan Carlsson and Angela George and Zoe Kemp and Jennifer Wiggins and Cathryn Moss and {Van As}, Nicholas and Alan Thompson and Chris Ogden and Christopher Woodhouse and Pardeep Kumar and Evans, {D. Gareth} and Barbara Bulman and Jeanette Rothwell and Karen Tricker and Gillian Wise and Catherine Mercer and Donna McBride and Philandra Costello and Allison Pearce and Audrey Torokwa and Joan Paterson and Virginia Clowes and Amy Taylor and Barbara Newcombe and Lisa Walker and Dorothy Halliday and Barbara Stayner and D. Fleming-Brown and Katie Snape and Helen Hanson and Shirley Hodgson and Glen Brice and Tessa Homfray and Carrie Hammond and Kelly Kohut and Uruj Anjum and Audrey Dearing and Mark Mencias and Alison Potter and Caroline Renton and Anne Searle and Kathryn Hill and Selina Goodman and Lynda Garcia and Gemma Devlin and Sarah Everest and Maria Nadolski and Fiona Douglas and Irene Jobson and Edgar Paez and Alan Donaldson and Sue Tomkins and Caroline Langman and Chris Jacobs and Tricia Heaton and Davis, {John W.}",
year = "2019",
month = "2",
doi = "10.1111/bju.14412",
language = "English",
volume = "123",
pages = "284--292",
journal = "British Journal of Urology International",
issn = "1464-410X",
publisher = "John Wiley & Sons",
number = "2",

}

Psychosocial impact of undergoing prostate cancer screening for men with BRCA1 or BRCA2 mutations. / IMPACT Study Steering Comm; IMPACT Collaborators.

In: BJU International, Vol. 123, No. 2, 02.2019, p. 284-292.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Psychosocial impact of undergoing prostate cancer screening for men with BRCA1 or BRCA2 mutations

AU - IMPACT Study Steering Comm

AU - IMPACT Collaborators

AU - Bancroft, Elizabeth K.

AU - Saya, Sibel

AU - Page, Elizabeth C.

AU - Myhill, Kathryn

AU - Thomas, Sarah

AU - Pope, Jennifer

AU - Chamberlain, Anthony

AU - Hart, Rachel

AU - Glover, Wayne

AU - Cook, Jackie

AU - Rosario, Derek J.

AU - Helfand, Brian T.

AU - Selkirk, Christina Hutten

AU - Davidson, Rosemarie

AU - Longmuir, Mark

AU - Eccles, Diana

AU - Gadea, Neus

AU - Brewer, Carole

AU - Barwell, Julian

AU - Salinas, Monica

AU - Greenhalgh, Lynn

AU - Tischkowitz, Marc

AU - Henderson, Alex

AU - Evans, David Gareth

AU - Buys, Saundra

AU - Eeles, Rosalind A.

AU - Aaronson, Neil K.

AU - Eeles, Rosalind

AU - Page, Elizabeth

AU - Kote-Jarai, Zsofia

AU - Ardern-Jones, Audrey

AU - Bangma, Chris

AU - Castro, Elena

AU - Dearnaley, David

AU - Falconer, Alison

AU - Foster, Christopher

AU - Gronberg, Henrik

AU - Hamdy, Freddie C.

AU - Johannsson, Oskar Thor

AU - Khoo, Vincent

AU - Eccles, Diana

AU - Lilja, Hans

AU - Evans, Gareth

AU - Eyfjord, Jorunn

AU - Lubinski, Jan

AU - Maehle, Lovise

AU - Mikropoulos, Christos

AU - Millner, Alan

AU - Mitra, Anita

AU - Offman, Judith

AU - Moynihan, Clare

AU - Rennert, Gad

AU - Suri, Mohnish

AU - Dias, Alex

AU - Taylor, Natalie

AU - D'Mello, Lucia

AU - Pope, Jenny

AU - James, Paul

AU - Mitchell, Gillian

AU - Shanley, Sue

AU - Richardson, Kate

AU - McKinley, Joanne

AU - Petelin, Lara

AU - Murphy, Morgan

AU - Mascarenhas, Lyon

AU - Murphy, Declan

AU - Lam, Jimmy

AU - Taylor, Louise

AU - Miller, Cathy

AU - Stapleton, Alan

AU - Chong, Michael

AU - Suthers, Graeme

AU - Poplawski, Nicola

AU - Tucker, Katherine

AU - Andrews, Lesley

AU - Duffy, Jessica

AU - Millard, Richard

AU - Ward, Robyn

AU - Williams, Rachel

AU - Stricker, Phillip

AU - Kirk, Judy

AU - Bowman, Michelle

AU - Patel, Manish

AU - Harris, Marion

AU - O'Connell, Shona

AU - Hunt, Clare

AU - Smyth, Courtney

AU - Frydenberg, Mark

AU - Lindeman, Geoffrey

AU - Shackleton, Kylie

AU - Morton, Catherine

AU - Susman, Rachel

AU - McGaughran, Julie

AU - Boon, Melanie

AU - Pachter, Nicholas

AU - Townshend, Sharron

AU - Schofield, Lyn

AU - Nicholls, Cassandra

AU - Spigelman, Allan

AU - Gleeson, Margaret

AU - Amor, David

AU - Burke, Jo

AU - Patterson, Briony

AU - Swindle, Peter

AU - Scott, Rodney

AU - Foulkes, William

AU - Boshari, Talia

AU - Aprikian, Armen

AU - Jensen, Thomas

AU - Bojeson, Anders

AU - Osther, Palle

AU - Skytte, Anne-Bine

AU - Cruger, Dorthe

AU - Tondering, Majbritt Kure

AU - Gerdes, Anne-Marie

AU - Schmutzler, Rita

AU - Rhiem, Kerstin

AU - Wihler, Petra

AU - Kast, K.

AU - Griebsch, C.

AU - Johannsson, Oskar

AU - Stefansdottir, Vigdis

AU - Murthy, Vedang

AU - Sarin, Rajiv

AU - Awatagiri, Kasturi

AU - Ghonge, Sujata

AU - Kowtal, Pradnya

AU - Mulgund, Gouri

AU - Gallagher, David

AU - Bambury, Richard

AU - Farrell, Michael

AU - Gallagher, Fergal

AU - Kiernan, Ingrid

AU - Friedman, Eitan

AU - Chen-Shtoyerman, Rakefet

AU - Basevitch, Alon

AU - Leibovici, Dan

AU - Melzer, Ehud

AU - Ben-Yehoshua, Sagi Josefsberg

AU - Nicolai, Nicola

AU - Radice, Paolo

AU - Valdagni, Riccardo

AU - Magnani, Tiziana

AU - Gay, Simona

AU - Teo, Soo Hwang

AU - Tan, Hui Meng

AU - Yoon, Sook-Yee

AU - Thong, Meow Keong

AU - Vasen, Hans

AU - Ringleberg, Janneke

AU - van Asperen, Christi

AU - Kiemeney, Bart

AU - van Zelst-Stams, Wendy

AU - Ausems, Margreet G. E. M.

AU - van der Luijt, Rob B.

AU - van Os, Theo

AU - Ruijs, Marielle W. G.

AU - Adank, Muriel A.

AU - Oldenburg, Rogier A.

AU - Helderman-van den Enden, A. Paula T. J. M.

AU - Caanen, B. A. H.

AU - Oosterwijk, Jan C.

AU - Moller, Pal

AU - Brennhovd, Bjorn

AU - Medvik, Heidi

AU - Hanslien, Eldbjorg

AU - Grindedal, Eli Marie

AU - Cybulski, Cezary

AU - Wokolorczyk, Dominika

AU - Teixeira, Manuel

AU - Maia, Sofia

AU - Peixoto, Ana

AU - Henrique, Rui

AU - Oliveira, Jorge

AU - Goncalves, Nuno

AU - Araujo, Luis

AU - Seixas, Manuela

AU - Souto, Joao Paulo

AU - Nogueira, Pedro

AU - Copakova, Lucia

AU - Zgajnar, Janez

AU - Krajc, Mateja

AU - Vrecar, Alenka

AU - Capella, Gabriel

AU - Ramon y Cajal, Teresa

AU - Fisas, David

AU - Mora, Josefina

AU - Esquena, Salvador

AU - Balmana, Judith

AU - Morote, Juan

AU - Liljegren, Annelie

AU - Hjalm-Eriksson, Marie

AU - Ekdahl, Karl-Johan

AU - Carlsson, Stefan

AU - George, Angela

AU - Kemp, Zoe

AU - Wiggins, Jennifer

AU - Moss, Cathryn

AU - Van As, Nicholas

AU - Thompson, Alan

AU - Ogden, Chris

AU - Woodhouse, Christopher

AU - Kumar, Pardeep

AU - Evans, D. Gareth

AU - Bulman, Barbara

AU - Rothwell, Jeanette

AU - Tricker, Karen

AU - Wise, Gillian

AU - Mercer, Catherine

AU - McBride, Donna

AU - Costello, Philandra

AU - Pearce, Allison

AU - Torokwa, Audrey

AU - Paterson, Joan

AU - Clowes, Virginia

AU - Taylor, Amy

AU - Newcombe, Barbara

AU - Walker, Lisa

AU - Halliday, Dorothy

AU - Stayner, Barbara

AU - Fleming-Brown, D.

AU - Snape, Katie

AU - Hanson, Helen

AU - Hodgson, Shirley

AU - Brice, Glen

AU - Homfray, Tessa

AU - Hammond, Carrie

AU - Kohut, Kelly

AU - Anjum, Uruj

AU - Dearing, Audrey

AU - Mencias, Mark

AU - Potter, Alison

AU - Renton, Caroline

AU - Searle, Anne

AU - Hill, Kathryn

AU - Goodman, Selina

AU - Garcia, Lynda

AU - Devlin, Gemma

AU - Everest, Sarah

AU - Nadolski, Maria

AU - Douglas, Fiona

AU - Jobson, Irene

AU - Paez, Edgar

AU - Donaldson, Alan

AU - Tomkins, Sue

AU - Langman, Caroline

AU - Jacobs, Chris

AU - Heaton, Tricia

AU - Davis, John W.

PY - 2019/2

Y1 - 2019/2

N2 - Objectives To report the baseline results of a longitudinal psychosocial study that forms part of the IMPACT study, a multi-national investigation of targeted prostate cancer (PCa) screening among men with a known pathogenic germline mutation in the BRCA1 or BRCA2 genes. Particpants and Methods Men enrolled in the IMPACT study were invited to complete a questionnaire at collaborating sites prior to each annual screening visit. The questionnaire included sociodemographic characteristics and the following measures: the Hospital Anxiety and Depression Scale (HADS), Impact of Event Scale (IES), 36-item short-form health survey (SF-36), Memorial Anxiety Scale for Prostate Cancer, Cancer Worry Scale-Revised, risk perception and knowledge. The results of the baseline questionnaire are presented. Results A total of 432 men completed questionnaires: 98 and 160 had mutations in BRCA1 and BRCA2 genes, respectively, and 174 were controls (familial mutation negative). Participants' perception of PCa risk was influenced by genetic status. Knowledge levels were high and unrelated to genetic status. Mean scores for the HADS and SF-36 were within reported general population norms and mean IES scores were within normal range. IES mean intrusion and avoidance scores were significantly higher in BRCA1/BRCA2 carriers than in controls and were higher in men with increased PCa risk perception. At the multivariate level, risk perception contributed more significantly to variance in IES scores than genetic status. Conclusion This is the first study to report the psychosocial profile of men with BRCA1/BRCA2 mutations undergoing PCa screening. No clinically concerning levels of general or cancer-specific distress or poor quality of life were detected in the cohort as a whole. A small subset of participants reported higher levels of distress, suggesting the need for healthcare professionals offering PCa screening to identify these risk factors and offer additional information and support to men seeking PCa screening.

AB - Objectives To report the baseline results of a longitudinal psychosocial study that forms part of the IMPACT study, a multi-national investigation of targeted prostate cancer (PCa) screening among men with a known pathogenic germline mutation in the BRCA1 or BRCA2 genes. Particpants and Methods Men enrolled in the IMPACT study were invited to complete a questionnaire at collaborating sites prior to each annual screening visit. The questionnaire included sociodemographic characteristics and the following measures: the Hospital Anxiety and Depression Scale (HADS), Impact of Event Scale (IES), 36-item short-form health survey (SF-36), Memorial Anxiety Scale for Prostate Cancer, Cancer Worry Scale-Revised, risk perception and knowledge. The results of the baseline questionnaire are presented. Results A total of 432 men completed questionnaires: 98 and 160 had mutations in BRCA1 and BRCA2 genes, respectively, and 174 were controls (familial mutation negative). Participants' perception of PCa risk was influenced by genetic status. Knowledge levels were high and unrelated to genetic status. Mean scores for the HADS and SF-36 were within reported general population norms and mean IES scores were within normal range. IES mean intrusion and avoidance scores were significantly higher in BRCA1/BRCA2 carriers than in controls and were higher in men with increased PCa risk perception. At the multivariate level, risk perception contributed more significantly to variance in IES scores than genetic status. Conclusion This is the first study to report the psychosocial profile of men with BRCA1/BRCA2 mutations undergoing PCa screening. No clinically concerning levels of general or cancer-specific distress or poor quality of life were detected in the cohort as a whole. A small subset of participants reported higher levels of distress, suggesting the need for healthcare professionals offering PCa screening to identify these risk factors and offer additional information and support to men seeking PCa screening.

KW - #pcsm

KW - #ProstateCancer

KW - BRCA1

KW - BRCA2

KW - psychosocial

KW - quality of life

KW - QUALITY-OF-LIFE

KW - FAMILY-HISTORY

KW - PSYCHOLOGICAL IMPACT

KW - HOSPITAL ANXIETY

KW - RISK PERCEPTION

KW - OVARIAN-CANCER

KW - BRCA1/2

KW - HEALTH

KW - POPULATION

KW - PSA

U2 - 10.1111/bju.14412

DO - 10.1111/bju.14412

M3 - Article

VL - 123

SP - 284

EP - 292

JO - British Journal of Urology International

JF - British Journal of Urology International

SN - 1464-410X

IS - 2

ER -