Psychiatric syndromes in Parkinson's disease

    Research output: Contribution to journalReview article

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    Abstract

    Purpose of review: To examine progress about relevant behavioural and psychiatric disorders in Parkinson's disease, such as depression, apathy, psychosis, and impulse control disorder.Recent findings: Several recent studies have characterized the phenomenology of depression in Parkinson's disease, and randomized controlled trials have demonstrated the efficacy of tricyclics, selective serotonin reuptake inhibitors and psychotherapy for depression in Parkinson's disease. Apathy is a valid behavioural syndrome in Parkinson's disease and is associated with depression and cognitive deficits. Psychosis is highly prevalent in the late stages of the disease, but there are few effective therapeutic modalities for this psychiatric condition. Impulse control disorders are also relatively frequent in Parkinson's disease, and are associated with comorbid psychiatric disorders.Summary: Standardized criteria should be used to diagnose depression and apathy in Parkinson's disease. Psychotherapy and pharmacotherapy are useful treatment modalities for affective disorders in Parkinson's disease. Clozapine is still the most effective, albeit rarely used, treatment for psychosis in Parkinson's disease. Impulse control disorders are relatively frequent in Parkinson's disease and all patients should be screened for this complex disorder.
    Original languageEnglish
    Pages (from-to)468-472
    JournalCurrent Opinion in Psychiatry
    Volume25
    Issue number6
    DOIs
    Publication statusPublished - 1 Nov 2012

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    Parkinson Disease
    Psychiatry
    Disruptive, Impulse Control, and Conduct Disorders
    Apathy
    Depression
    Psychotic Disorders
    Psychotherapy
    Clozapine
    Serotonin Uptake Inhibitors
    Mood Disorders
    Therapeutics
    Randomized Controlled Trials
    Drug Therapy

    Cite this

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    title = "Psychiatric syndromes in Parkinson's disease",
    abstract = "Purpose of review: To examine progress about relevant behavioural and psychiatric disorders in Parkinson's disease, such as depression, apathy, psychosis, and impulse control disorder.Recent findings: Several recent studies have characterized the phenomenology of depression in Parkinson's disease, and randomized controlled trials have demonstrated the efficacy of tricyclics, selective serotonin reuptake inhibitors and psychotherapy for depression in Parkinson's disease. Apathy is a valid behavioural syndrome in Parkinson's disease and is associated with depression and cognitive deficits. Psychosis is highly prevalent in the late stages of the disease, but there are few effective therapeutic modalities for this psychiatric condition. Impulse control disorders are also relatively frequent in Parkinson's disease, and are associated with comorbid psychiatric disorders.Summary: Standardized criteria should be used to diagnose depression and apathy in Parkinson's disease. Psychotherapy and pharmacotherapy are useful treatment modalities for affective disorders in Parkinson's disease. Clozapine is still the most effective, albeit rarely used, treatment for psychosis in Parkinson's disease. Impulse control disorders are relatively frequent in Parkinson's disease and all patients should be screened for this complex disorder.",
    author = "Sergio Starkstein and Simone Brockman and Bradleigh Hayhow",
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    Psychiatric syndromes in Parkinson's disease. / Starkstein, Sergio; Brockman, Simone; Hayhow, Bradleigh.

    In: Current Opinion in Psychiatry, Vol. 25, No. 6, 01.11.2012, p. 468-472.

    Research output: Contribution to journalReview article

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    T1 - Psychiatric syndromes in Parkinson's disease

    AU - Starkstein, Sergio

    AU - Brockman, Simone

    AU - Hayhow, Bradleigh

    PY - 2012/11/1

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    AB - Purpose of review: To examine progress about relevant behavioural and psychiatric disorders in Parkinson's disease, such as depression, apathy, psychosis, and impulse control disorder.Recent findings: Several recent studies have characterized the phenomenology of depression in Parkinson's disease, and randomized controlled trials have demonstrated the efficacy of tricyclics, selective serotonin reuptake inhibitors and psychotherapy for depression in Parkinson's disease. Apathy is a valid behavioural syndrome in Parkinson's disease and is associated with depression and cognitive deficits. Psychosis is highly prevalent in the late stages of the disease, but there are few effective therapeutic modalities for this psychiatric condition. Impulse control disorders are also relatively frequent in Parkinson's disease, and are associated with comorbid psychiatric disorders.Summary: Standardized criteria should be used to diagnose depression and apathy in Parkinson's disease. Psychotherapy and pharmacotherapy are useful treatment modalities for affective disorders in Parkinson's disease. Clozapine is still the most effective, albeit rarely used, treatment for psychosis in Parkinson's disease. Impulse control disorders are relatively frequent in Parkinson's disease and all patients should be screened for this complex disorder.

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