Pseudo-multiple sclerosis: a clinico-epidemiological study

G J Hankey, E G Stewart-Wynne

Research output: Contribution to journalArticle

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Abstract

Despite the advance represented by nuclear magnetic resonance imaging, the diagnosis of multiple sclerosis (MS) remains clinical. It has been our impression that a diagnosis of MS reduces further critical neurological thought and assumes an air of certainty after a number of visits in the absence of any new evidence for the diagnosis. One of us (E.G.S-W.), as part of a nationwide epidemiological study, reviewed 387 patients in Western Australia who had been diagnosed as having MS. Three diagnostic sub-groups were identified: group A--318 patients considered to have MS, group B--32 patients with an alternative chronic neurological disorder, and group C--35 patients not considered to have a neurological illness. Patients in group C were predominantly females (89%) and nurses (34%) with an earlier age of onset of symptoms (mean 28 years, range 12-46 years). Frequent clinical features included monocular diplopia, tunnel vision, 'give-way' weakness and hemisensory loss of all modalities of sensation. The major clinical features of patients in group B, which were atypical for MS, included onset of non-remitting, progressive disease before age 35 years, localised disease, and normal optic nerves and eye movements. The results of this study serve to promote critical analysis of the accuracy of diagnosis of MS in individual cases.

Original languageEnglish
Pages (from-to)11-9
Number of pages9
JournalClinical and experimental neurology
Volume24
Publication statusPublished - 1987
Externally publishedYes

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Multiple Sclerosis
Epidemiologic Studies
Optic Nerve Diseases
Western Australia
Diplopia
Eye Movements
Nervous System Diseases
Age of Onset
Magnetic Resonance Spectroscopy
Nurses
Air
Magnetic Resonance Imaging

Cite this

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Pseudo-multiple sclerosis : a clinico-epidemiological study. / Hankey, G J; Stewart-Wynne, E G.

In: Clinical and experimental neurology, Vol. 24, 1987, p. 11-9.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Pseudo-multiple sclerosis

T2 - a clinico-epidemiological study

AU - Hankey, G J

AU - Stewart-Wynne, E G

PY - 1987

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AB - Despite the advance represented by nuclear magnetic resonance imaging, the diagnosis of multiple sclerosis (MS) remains clinical. It has been our impression that a diagnosis of MS reduces further critical neurological thought and assumes an air of certainty after a number of visits in the absence of any new evidence for the diagnosis. One of us (E.G.S-W.), as part of a nationwide epidemiological study, reviewed 387 patients in Western Australia who had been diagnosed as having MS. Three diagnostic sub-groups were identified: group A--318 patients considered to have MS, group B--32 patients with an alternative chronic neurological disorder, and group C--35 patients not considered to have a neurological illness. Patients in group C were predominantly females (89%) and nurses (34%) with an earlier age of onset of symptoms (mean 28 years, range 12-46 years). Frequent clinical features included monocular diplopia, tunnel vision, 'give-way' weakness and hemisensory loss of all modalities of sensation. The major clinical features of patients in group B, which were atypical for MS, included onset of non-remitting, progressive disease before age 35 years, localised disease, and normal optic nerves and eye movements. The results of this study serve to promote critical analysis of the accuracy of diagnosis of MS in individual cases.

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KW - Male

KW - Middle Aged

KW - Multiple Sclerosis/diagnosis

KW - Nervous System Diseases/diagnosis

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