TY - JOUR
T1 - Protocol for the development of a core outcome set for neonatal sepsis (NESCOS)
AU - Taneri, Petek Eylul
AU - Kirkham, Jamie J.
AU - Molloy, Eleanor J.
AU - Biesty, Linda
AU - Polin, Richard A.
AU - Wynn, James L.
AU - Stoll, Barbara J.
AU - Kissoon, Niranjan
AU - Kawaza, Kondwani
AU - Daly, Mandy
AU - Branagan, Aoife
AU - Bonnard, Lívia Nagy
AU - Giannoni, Eric
AU - Strunk, Tobias
AU - Ohaja, Magdalena
AU - Mugabe, Kenneth
AU - Suguitani, Denise
AU - Quirke, Fiona
AU - Devane, Declan
N1 - Funding Information:
This research was funded by the Health Research Board (HRB, Ireland) through funding to the HRB Irish Network for Children’s Clinical Trials (In4Kids) [Grant number: CTN-2021-007] Funders did not play any role in the study design, data collection (when applicable) and analysis, decision to publish, or preparation of the manuscript.
Publisher Copyright:
© 2023 Taneri et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2023/12/5
Y1 - 2023/12/5
N2 - Neonatal sepsis is a serious public health problem; however, there is substantial heterogeneity in the outcomes measured and reported in research evaluating the effectiveness of the treatments. Therefore, we aim to develop a Core Outcome Set (COS) for studies evaluating the effectiveness of treatments for neonatal sepsis. Since a systematic review of key outcomes from randomised trials of therapeutic interventions in neonatal sepsis was published recently, we will complement this with a qualitative systematic review of the key outcomes of neonatal sepsis identified by parents, other family members, parent representatives, healthcare providers, policymakers, and researchers. We will interpret the outcomes of both studies using a previously established framework. Stakeholders across three different groups i.e., (1) researchers, (2) healthcare providers, and (3) patients’ parents/family members and parent representatives will rate the importance of the outcomes in an online Real-Time Delphi Survey. Afterwards, consensus meetings will be held to agree on the final COS through online discussions with key stakeholders. This COS is expected to minimize outcome heterogeneity in measurements and publications, improve comparability and synthesis, and decrease research waste.
AB - Neonatal sepsis is a serious public health problem; however, there is substantial heterogeneity in the outcomes measured and reported in research evaluating the effectiveness of the treatments. Therefore, we aim to develop a Core Outcome Set (COS) for studies evaluating the effectiveness of treatments for neonatal sepsis. Since a systematic review of key outcomes from randomised trials of therapeutic interventions in neonatal sepsis was published recently, we will complement this with a qualitative systematic review of the key outcomes of neonatal sepsis identified by parents, other family members, parent representatives, healthcare providers, policymakers, and researchers. We will interpret the outcomes of both studies using a previously established framework. Stakeholders across three different groups i.e., (1) researchers, (2) healthcare providers, and (3) patients’ parents/family members and parent representatives will rate the importance of the outcomes in an online Real-Time Delphi Survey. Afterwards, consensus meetings will be held to agree on the final COS through online discussions with key stakeholders. This COS is expected to minimize outcome heterogeneity in measurements and publications, improve comparability and synthesis, and decrease research waste.
UR - http://www.scopus.com/inward/record.url?scp=85178850161&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0295325
DO - 10.1371/journal.pone.0295325
M3 - Article
C2 - 38051733
AN - SCOPUS:85178850161
SN - 1932-6203
VL - 18
JO - PLoS One
JF - PLoS One
IS - 12 December
M1 - e0295325
ER -
