Protein thiol oxidation and the skeletal muscle pathology in animal models of Duchenne Muscular Dystrophy

Research output: ThesisDoctoral Thesis

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Abstract

Duchenne muscular dystrophy (DMD) is an incurable X-linked disease characterised by progressive muscle weakness and wasting leading to premature death. This thesis explored the role of oxidative stress in the pathophysiology of DMD, with a focus on dystrophic muscle protein thiol oxidation. Experiments were undertaken using the dystrophic mdx mouse and GRMD dog models, and a novel dystrophic mouse strain with enhanced exercise capability. The results of this thesis suggest that reducing dystrophic muscle protein thiol oxidation could reduce the functional deficits seen in dystrophic muscle and reduce the severity and progression of the disease.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Bakker, Tony, Supervisor
  • Arthur, Peter, Supervisor
  • Pinniger, Gavin, Supervisor
Thesis sponsors
Award date15 Oct 2019
DOIs
Publication statusUnpublished - 2019

Embargo information

  • Embargoed from 17/10/2019 to 31/05/2021. Made publicly available on 31/05/2021.

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