Abstract
Age-related loss of skeletal muscle mass and function is termed sarcopenia. This thesis investigated the main signalling pathway known to control protein turnover (IGF-1-mTORC1) in aged muscle, including pathway modulators (fasting and IGF-1 overexpression), and assessed the capacity of wheel-running protocols (resistance and endurance) to prevent sarcopenia. These studies determined that irregular mTORC1 signalling coincides with sarcopenia onset, a defect that is exacerbated under fasting conditions. Furthermore, resistance exercise Initiated from mid-life had the greatest benefit on muscle mass (assessed late-age), whereby sarcopenia was prevented and physiological parameters improved: including mitochondrial
content, oxidative capacity and select autophagy markers.
content, oxidative capacity and select autophagy markers.
Original language | English |
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Qualification | Doctor of Philosophy |
Awarding Institution |
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Supervisors/Advisors |
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Award date | 7 Feb 2017 |
Publication status | Unpublished - 2016 |