Protein homeostasis and sarcopenia: the influence of fasting and exercise on protein synthesis and degradation pathways

Zoe Rene White

    Research output: ThesisDoctoral Thesis

    1206 Downloads (Pure)

    Abstract

    Age-related loss of skeletal muscle mass and function is termed sarcopenia. This thesis investigated the main signalling pathway known to control protein turnover (IGF-1-mTORC1) in aged muscle, including pathway modulators (fasting and IGF-1 overexpression), and assessed the capacity of wheel-running protocols (resistance and endurance) to prevent sarcopenia. These studies determined that irregular mTORC1 signalling coincides with sarcopenia onset, a defect that is exacerbated under fasting conditions. Furthermore, resistance exercise Initiated from mid-life had the greatest benefit on muscle mass (assessed late-age), whereby sarcopenia was prevented and physiological parameters improved: including mitochondrial
    content, oxidative capacity and select autophagy markers.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • The University of Western Australia
    Supervisors/Advisors
    • Shavlakadze, Tea, Supervisor
    • Grounds, Miranda, Supervisor
    • White, Robert, Supervisor
    Award date7 Feb 2017
    Publication statusUnpublished - 2016

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