Protein Delivery into the Cell Cytosol using Non-Viral Nanocarriers

Yi-Wei Lee, David C. Luther, Jessica A. Kretzmann, Andrew Burden, Taewon Jeon, Shumei Zhai, Vincent M. Rotello

Research output: Contribution to journalReview articlepeer-review

47 Citations (Web of Science)


Protein delivery into cells is a potentially transformative tool for treating "undruggable" targets in diseases associated with protein deficiencies or mutations. The vast majority of these targets are accessed via the cytosol, a challenging prospect for proteins with therapeutic and diagnostic relevance. In this review we will present promising non-viral approaches for intracellular and ultimately cytosolic delivery of proteins using nanocarriers. We will also discuss the mechanistic properties that govern the efficacy of nanocarrier-mediated protein delivery, applications of nanomaterials, and key challenges and opportunities in the use of nanocarriers for intracellular protein delivery.

Original languageEnglish
Pages (from-to)3280-3292
Number of pages13
Issue number11
Publication statusPublished - 2019


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