TY - JOUR
T1 - Protective ventilation of preterm lambs exposed to acute chorioamnionitis does not reduce ventilation-induced lung or brain injury
AU - Barton, S.K.
AU - Moss, T.J.M.
AU - Hooper, S.B.
AU - Crossley, K.J.
AU - Gill, Andrew
AU - Kluckow, M.R.
AU - Zahra, V.A.
AU - Wong, F.Y.
AU - Pichler, G.
AU - Galinsky, R.
AU - Miller, S.L.
AU - Tolcos, M.
AU - Polglase, G.R.
PY - 2014/11/7
Y1 - 2014/11/7
N2 - © 2014 Barton et al. Background: The onset of mechanical ventilation is a critical time for the initiation of cerebral white matter (WM) injury in preterm neonates, particularly if they are inadvertently exposed to high tidal volumes (VT) in the delivery room. Protective ventilation strategies at birth reduce ventilation-induced lung and brain inflammation and injury, however its efficacy in a compromised newborn is not known. Chorioamnionitis is a common antecedent of preterm birth, and increases the risk and severity of WM injury. We investigated the effects of high VT ventilation, after chorioamnionitis, on preterm lung and WM inflammation and injury, and whether a protective ventilation strategy could mitigate the response. Results: LPSINJ lambs had poorer oxygenation than LPSPROT lambs. Ventilation requirements and cardiopulmonary and systemic haemodynamics were not different between ventilation strategies. Compared to unventilated lambs, LPSINJ and LPSPROT lambs had increases in pro-inflammatory cytokine expression within the lungs and brain, and increased astrogliosis (p
AB - © 2014 Barton et al. Background: The onset of mechanical ventilation is a critical time for the initiation of cerebral white matter (WM) injury in preterm neonates, particularly if they are inadvertently exposed to high tidal volumes (VT) in the delivery room. Protective ventilation strategies at birth reduce ventilation-induced lung and brain inflammation and injury, however its efficacy in a compromised newborn is not known. Chorioamnionitis is a common antecedent of preterm birth, and increases the risk and severity of WM injury. We investigated the effects of high VT ventilation, after chorioamnionitis, on preterm lung and WM inflammation and injury, and whether a protective ventilation strategy could mitigate the response. Results: LPSINJ lambs had poorer oxygenation than LPSPROT lambs. Ventilation requirements and cardiopulmonary and systemic haemodynamics were not different between ventilation strategies. Compared to unventilated lambs, LPSINJ and LPSPROT lambs had increases in pro-inflammatory cytokine expression within the lungs and brain, and increased astrogliosis (p
U2 - 10.1371/journal.pone.0112402
DO - 10.1371/journal.pone.0112402
M3 - Article
C2 - 25379714
SN - 1932-6203
VL - 9
SP - 1
EP - 10
JO - PLoS One
JF - PLoS One
IS - 11
ER -