Protective efficacy of heat-inactivated B. thailandensis, B. mallei or B. pseudomallei against experimental melioidosis and glanders

Mitali Sarkar-Tyson, S.J. J. Smither, S.V. V. Harding, T.P. P. Atkins, R.W. W. Titball

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Burkholderia pseudomallei and Burkholderia mallei are gram-negative bacilli that are the causative agents of melioidosis and glanders, respectively. Both humans and animals are susceptible to both diseases. There is currently no vaccine available for the prevention of disease. We report the protective efficacy of heat-inactivated Burkholderia thailandensis, B. mallei or B. pseudomallei cells as vaccines against murine melioidosis and glanders. Immunisation with heat-inactivated B. pseudomallei cells provided the highest levels of protection against either melioidosis or glanders. These studies indicate the longer term potential for heat-inactivated bacteria to be developed as vaccines against melioidosis and glanders. Crown Copyright © 2009.
Original languageEnglish
Pages (from-to)4447-4451
Number of pages5
JournalVaccine
Volume27
Issue number33
DOIs
Publication statusPublished - 2009

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