Prospects for the treatment of drug-resistant malaria parasites

L. Tilley, Timothy Davis, P.G. Bray

    Research output: Contribution to journalArticle

    19 Citations (Scopus)

    Abstract

    Widespread parasitic resistance has led to an urgent need for the development and implementation of new drugs for the treatment of Plasmodium foiciparum malaria. Artemisinin and its derivatives are becoming increasingly important, used preferably in combination with a second antimalarial agent to increase the efficacy and slow the development of resistance. However, cost, production and pharmacological issues associated with artemisinin derivatives and potential partner drugs are hindering the implementation of combination therapies. This article reviews the molecular basis of the action of, and resistance to, different antimalarials and examines the prospects for the next generation of drugs to combat this potentially lethal human pathogen.
    Original languageEnglish
    Pages (from-to)127-141
    JournalFuture Microbiology
    Volume1
    Issue number1
    DOIs
    Publication statusPublished - 2006

    Fingerprint Dive into the research topics of 'Prospects for the treatment of drug-resistant malaria parasites'. Together they form a unique fingerprint.

    Cite this