Prospective memory in schizophrenia: A meta-analysis of comparative studies

Fu Chun Zhou, Wei Zheng, Li Lu, Yuan Yuan Wang, Chee H. Ng, Gabor S. Ungvari, Jun Li, Yu Tao Xiang

Research output: Contribution to journalArticle

Abstract

Background: Impairment of prospective memory (PM) in schizophrenia has gained increasing attention. This meta-analysis systematically examined PM impairment in schizophrenia. Methods: Both English (PubMed, PsycINFO, EMBASE, and Cochrane Library) and Chinese (WanFang, Chinese Biomedical and China Journal Net databases) databases were systematically searched from their inception until August 14, 2017. Case-control studies of PM in schizophrenia were included. Standardized mean differences (SMDs) and their 95% confidence interval (CI) were calculated using the random-effects model. Results: Twenty-nine case-control studies (n = 2492) were included in the analyses. The overall and three subtypes of PM were compared between patients with schizophrenia (n = 1284) and healthy controls (n = 1208). Compared to healthy controls, patients performed significantly poorer in overall (SMD = −1.125), time-based (SMD = −1.155), event-based (SMD = −1.068), and activity-based PM (SMD = -0.563). Subgroup analyses revealed significant differences between older and younger patients (SMD = -1.398 vs. -0.763), higher male predominance and no sex predominance (SMD = -1.679 vs. -0.800), lower and higher education level (SMD = -1.373 vs.-0.637), chronic and first-episode patients (SMD = -1.237 vs. -0.641) and between eco-valid and dual-task laboratory measurements (SMD = -1.542 vs. -0.725) regarding overall PM. Meta-regression analysis showed that higher negative symptom score was significantly associated with more severe overall PM impairment in patients (P = 0.022). Conclusions: In this meta-analysis the overall PM and all its subtypes, particularly the time-based PM, were significantly impaired in schizophrenia.

Original languageEnglish
Pages (from-to)62-71
JournalSchizophrenia Research
Volume212
DOIs
Publication statusPublished - Oct 2019

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Episodic Memory
Meta-Analysis
Schizophrenia
Case-Control Studies
Databases
PubMed
Libraries
China
Regression Analysis
Confidence Intervals
Education

Cite this

Zhou, Fu Chun ; Zheng, Wei ; Lu, Li ; Wang, Yuan Yuan ; Ng, Chee H. ; Ungvari, Gabor S. ; Li, Jun ; Xiang, Yu Tao. / Prospective memory in schizophrenia : A meta-analysis of comparative studies. In: Schizophrenia Research. 2019 ; Vol. 212. pp. 62-71.
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abstract = "Background: Impairment of prospective memory (PM) in schizophrenia has gained increasing attention. This meta-analysis systematically examined PM impairment in schizophrenia. Methods: Both English (PubMed, PsycINFO, EMBASE, and Cochrane Library) and Chinese (WanFang, Chinese Biomedical and China Journal Net databases) databases were systematically searched from their inception until August 14, 2017. Case-control studies of PM in schizophrenia were included. Standardized mean differences (SMDs) and their 95{\%} confidence interval (CI) were calculated using the random-effects model. Results: Twenty-nine case-control studies (n = 2492) were included in the analyses. The overall and three subtypes of PM were compared between patients with schizophrenia (n = 1284) and healthy controls (n = 1208). Compared to healthy controls, patients performed significantly poorer in overall (SMD = −1.125), time-based (SMD = −1.155), event-based (SMD = −1.068), and activity-based PM (SMD = -0.563). Subgroup analyses revealed significant differences between older and younger patients (SMD = -1.398 vs. -0.763), higher male predominance and no sex predominance (SMD = -1.679 vs. -0.800), lower and higher education level (SMD = -1.373 vs.-0.637), chronic and first-episode patients (SMD = -1.237 vs. -0.641) and between eco-valid and dual-task laboratory measurements (SMD = -1.542 vs. -0.725) regarding overall PM. Meta-regression analysis showed that higher negative symptom score was significantly associated with more severe overall PM impairment in patients (P = 0.022). Conclusions: In this meta-analysis the overall PM and all its subtypes, particularly the time-based PM, were significantly impaired in schizophrenia.",
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author = "Zhou, {Fu Chun} and Wei Zheng and Li Lu and Wang, {Yuan Yuan} and Ng, {Chee H.} and Ungvari, {Gabor S.} and Jun Li and Xiang, {Yu Tao}",
year = "2019",
month = "10",
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journal = "Schizophrenia Research",
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Prospective memory in schizophrenia : A meta-analysis of comparative studies. / Zhou, Fu Chun; Zheng, Wei; Lu, Li; Wang, Yuan Yuan; Ng, Chee H.; Ungvari, Gabor S.; Li, Jun; Xiang, Yu Tao.

In: Schizophrenia Research, Vol. 212, 10.2019, p. 62-71.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prospective memory in schizophrenia

T2 - A meta-analysis of comparative studies

AU - Zhou, Fu Chun

AU - Zheng, Wei

AU - Lu, Li

AU - Wang, Yuan Yuan

AU - Ng, Chee H.

AU - Ungvari, Gabor S.

AU - Li, Jun

AU - Xiang, Yu Tao

PY - 2019/10

Y1 - 2019/10

N2 - Background: Impairment of prospective memory (PM) in schizophrenia has gained increasing attention. This meta-analysis systematically examined PM impairment in schizophrenia. Methods: Both English (PubMed, PsycINFO, EMBASE, and Cochrane Library) and Chinese (WanFang, Chinese Biomedical and China Journal Net databases) databases were systematically searched from their inception until August 14, 2017. Case-control studies of PM in schizophrenia were included. Standardized mean differences (SMDs) and their 95% confidence interval (CI) were calculated using the random-effects model. Results: Twenty-nine case-control studies (n = 2492) were included in the analyses. The overall and three subtypes of PM were compared between patients with schizophrenia (n = 1284) and healthy controls (n = 1208). Compared to healthy controls, patients performed significantly poorer in overall (SMD = −1.125), time-based (SMD = −1.155), event-based (SMD = −1.068), and activity-based PM (SMD = -0.563). Subgroup analyses revealed significant differences between older and younger patients (SMD = -1.398 vs. -0.763), higher male predominance and no sex predominance (SMD = -1.679 vs. -0.800), lower and higher education level (SMD = -1.373 vs.-0.637), chronic and first-episode patients (SMD = -1.237 vs. -0.641) and between eco-valid and dual-task laboratory measurements (SMD = -1.542 vs. -0.725) regarding overall PM. Meta-regression analysis showed that higher negative symptom score was significantly associated with more severe overall PM impairment in patients (P = 0.022). Conclusions: In this meta-analysis the overall PM and all its subtypes, particularly the time-based PM, were significantly impaired in schizophrenia.

AB - Background: Impairment of prospective memory (PM) in schizophrenia has gained increasing attention. This meta-analysis systematically examined PM impairment in schizophrenia. Methods: Both English (PubMed, PsycINFO, EMBASE, and Cochrane Library) and Chinese (WanFang, Chinese Biomedical and China Journal Net databases) databases were systematically searched from their inception until August 14, 2017. Case-control studies of PM in schizophrenia were included. Standardized mean differences (SMDs) and their 95% confidence interval (CI) were calculated using the random-effects model. Results: Twenty-nine case-control studies (n = 2492) were included in the analyses. The overall and three subtypes of PM were compared between patients with schizophrenia (n = 1284) and healthy controls (n = 1208). Compared to healthy controls, patients performed significantly poorer in overall (SMD = −1.125), time-based (SMD = −1.155), event-based (SMD = −1.068), and activity-based PM (SMD = -0.563). Subgroup analyses revealed significant differences between older and younger patients (SMD = -1.398 vs. -0.763), higher male predominance and no sex predominance (SMD = -1.679 vs. -0.800), lower and higher education level (SMD = -1.373 vs.-0.637), chronic and first-episode patients (SMD = -1.237 vs. -0.641) and between eco-valid and dual-task laboratory measurements (SMD = -1.542 vs. -0.725) regarding overall PM. Meta-regression analysis showed that higher negative symptom score was significantly associated with more severe overall PM impairment in patients (P = 0.022). Conclusions: In this meta-analysis the overall PM and all its subtypes, particularly the time-based PM, were significantly impaired in schizophrenia.

KW - Cognitive impairment

KW - Meta-analysis

KW - Prospective memory

KW - Schizophrenia

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