Prospective memory deficits in patients with depression: A meta-analysis

Fu Chun Zhou, Yuan Yuan Wang, Wei Zheng, Qinge Zhang, Gabor S. Ungvari, Chee H. Ng, Juan Zhang, Yu-Tao Xiang

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Abstract

Background Prospective memory (PM) can be impaired in patients with psychiatric disorders including depression. This meta-analysis systematically examined PM in patients with depression. Methods The meta-analysis was conducted according to the guidelines from Strengthening the Reporting of Observational studies in Epidemiology (STROBE). Case-control studies on PM in patients with depression were included. Standardized mean differences (SMDs) and 95% confidence interval (CI) were calculated using random effect models. Results Ten case-control studies (n = 596) comparing patients with depression (n = 299) with healthy controls (n = 297) were included in the analyses. Compared with healthy controls, patients with depression had significant impairment in event-based PM (EBPM) [8 trials, n = 436; SMD: −0.87 (95%CI: −1.43, −0.31), P = 0.002; I2 = 87%]. Significance was observed after removing two outlier trials [SMD: −0.44 (95%CI: −0.69, −0.20), P = 0.0004; I2 = 23%] and also in 8 out of the 13 subgroup analyses. Similarly, time-based PM (TBPM) was significantly impaired in patients with depression [4 trials, n = 239; SMD: −0.89 (95%CI: −1.46, −0.31), P = 0.003; I2 = 78%] when compared with healthy controls. Conclusions This meta-analysis showed that both TBPM and EBPM appeared to be impaired in patients with depression.

LanguageEnglish
Pages79-85
Number of pages7
JournalJournal of Affective Disorders
Volume220
DOIs
StatePublished - 1 Oct 2017

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Episodic Memory
Memory Disorders
Meta-Analysis
Depression
Confidence Intervals
Case-Control Studies
Observational Studies
Psychiatry
Epidemiology
Guidelines

Cite this

Zhou, F. C., Wang, Y. Y., Zheng, W., Zhang, Q., Ungvari, G. S., Ng, C. H., ... Xiang, Y-T. (2017). Prospective memory deficits in patients with depression: A meta-analysis. Journal of Affective Disorders, 220, 79-85. DOI: 10.1016/j.jad.2017.05.042
Zhou, Fu Chun ; Wang, Yuan Yuan ; Zheng, Wei ; Zhang, Qinge ; Ungvari, Gabor S. ; Ng, Chee H. ; Zhang, Juan ; Xiang, Yu-Tao. / Prospective memory deficits in patients with depression : A meta-analysis. In: Journal of Affective Disorders. 2017 ; Vol. 220. pp. 79-85
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title = "Prospective memory deficits in patients with depression: A meta-analysis",
abstract = "Background Prospective memory (PM) can be impaired in patients with psychiatric disorders including depression. This meta-analysis systematically examined PM in patients with depression. Methods The meta-analysis was conducted according to the guidelines from Strengthening the Reporting of Observational studies in Epidemiology (STROBE). Case-control studies on PM in patients with depression were included. Standardized mean differences (SMDs) and 95{\%} confidence interval (CI) were calculated using random effect models. Results Ten case-control studies (n = 596) comparing patients with depression (n = 299) with healthy controls (n = 297) were included in the analyses. Compared with healthy controls, patients with depression had significant impairment in event-based PM (EBPM) [8 trials, n = 436; SMD: −0.87 (95{\%}CI: −1.43, −0.31), P = 0.002; I2 = 87{\%}]. Significance was observed after removing two outlier trials [SMD: −0.44 (95{\%}CI: −0.69, −0.20), P = 0.0004; I2 = 23{\%}] and also in 8 out of the 13 subgroup analyses. Similarly, time-based PM (TBPM) was significantly impaired in patients with depression [4 trials, n = 239; SMD: −0.89 (95{\%}CI: −1.46, −0.31), P = 0.003; I2 = 78{\%}] when compared with healthy controls. Conclusions This meta-analysis showed that both TBPM and EBPM appeared to be impaired in patients with depression.",
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Zhou, FC, Wang, YY, Zheng, W, Zhang, Q, Ungvari, GS, Ng, CH, Zhang, J & Xiang, Y-T 2017, 'Prospective memory deficits in patients with depression: A meta-analysis' Journal of Affective Disorders, vol 220, pp. 79-85. DOI: 10.1016/j.jad.2017.05.042

Prospective memory deficits in patients with depression : A meta-analysis. / Zhou, Fu Chun; Wang, Yuan Yuan; Zheng, Wei; Zhang, Qinge; Ungvari, Gabor S.; Ng, Chee H.; Zhang, Juan; Xiang, Yu-Tao.

In: Journal of Affective Disorders, Vol. 220, 01.10.2017, p. 79-85.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prospective memory deficits in patients with depression

T2 - Journal of Affective Disorders

AU - Zhou,Fu Chun

AU - Wang,Yuan Yuan

AU - Zheng,Wei

AU - Zhang,Qinge

AU - Ungvari,Gabor S.

AU - Ng,Chee H.

AU - Zhang,Juan

AU - Xiang,Yu-Tao

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Background Prospective memory (PM) can be impaired in patients with psychiatric disorders including depression. This meta-analysis systematically examined PM in patients with depression. Methods The meta-analysis was conducted according to the guidelines from Strengthening the Reporting of Observational studies in Epidemiology (STROBE). Case-control studies on PM in patients with depression were included. Standardized mean differences (SMDs) and 95% confidence interval (CI) were calculated using random effect models. Results Ten case-control studies (n = 596) comparing patients with depression (n = 299) with healthy controls (n = 297) were included in the analyses. Compared with healthy controls, patients with depression had significant impairment in event-based PM (EBPM) [8 trials, n = 436; SMD: −0.87 (95%CI: −1.43, −0.31), P = 0.002; I2 = 87%]. Significance was observed after removing two outlier trials [SMD: −0.44 (95%CI: −0.69, −0.20), P = 0.0004; I2 = 23%] and also in 8 out of the 13 subgroup analyses. Similarly, time-based PM (TBPM) was significantly impaired in patients with depression [4 trials, n = 239; SMD: −0.89 (95%CI: −1.46, −0.31), P = 0.003; I2 = 78%] when compared with healthy controls. Conclusions This meta-analysis showed that both TBPM and EBPM appeared to be impaired in patients with depression.

AB - Background Prospective memory (PM) can be impaired in patients with psychiatric disorders including depression. This meta-analysis systematically examined PM in patients with depression. Methods The meta-analysis was conducted according to the guidelines from Strengthening the Reporting of Observational studies in Epidemiology (STROBE). Case-control studies on PM in patients with depression were included. Standardized mean differences (SMDs) and 95% confidence interval (CI) were calculated using random effect models. Results Ten case-control studies (n = 596) comparing patients with depression (n = 299) with healthy controls (n = 297) were included in the analyses. Compared with healthy controls, patients with depression had significant impairment in event-based PM (EBPM) [8 trials, n = 436; SMD: −0.87 (95%CI: −1.43, −0.31), P = 0.002; I2 = 87%]. Significance was observed after removing two outlier trials [SMD: −0.44 (95%CI: −0.69, −0.20), P = 0.0004; I2 = 23%] and also in 8 out of the 13 subgroup analyses. Similarly, time-based PM (TBPM) was significantly impaired in patients with depression [4 trials, n = 239; SMD: −0.89 (95%CI: −1.46, −0.31), P = 0.003; I2 = 78%] when compared with healthy controls. Conclusions This meta-analysis showed that both TBPM and EBPM appeared to be impaired in patients with depression.

KW - Depression

KW - Meta-analysis

KW - Prospective memory

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Zhou FC, Wang YY, Zheng W, Zhang Q, Ungvari GS, Ng CH et al. Prospective memory deficits in patients with depression: A meta-analysis. Journal of Affective Disorders. 2017 Oct 1;220:79-85. Available from, DOI: 10.1016/j.jad.2017.05.042