Projects per year
Abstract
Dietary fat intake has long been associated with fatty liver. Our study aimed to determine the effect of dietary fats on longitudinal fatty liver index (FLI) trajectories from adolescence to young adulthood.
Methods
Nine hundred eighty-five participants in the Raine Study, Perth, Western Australia, Australia, had cross-sectional assessments at ages 14, 17, 20 and 22 years, during which anthropometric measurements and blood tests were obtained. FLI trajectories were derived from the longitudinal FLI results. Dietary fat intake was measured with a semi-quantitative food frequency questionnaire at 14 years and log multinominal regression analyses were used to estimate relative risks.
Results
Three FLI trajectories were identified and labelled as stable-low (79.1%, N = 782), low-to-high (13.9%, N = 132), and stable-high (7%, N = 71). The low-to-high group associated with an increased intake of the long-chain polyunsaturated fatty acids EPA, DPA and DHA (RR 1.27, 95% CI 1.10–1.48) relative to the stable-low group. Compared to the stable-low group, omega-6 and the ratio of omega-6 to omega-3 in the stable-high group were associated with an increased relative risk of 1.34 (95% CI 1.02–1.76) and 1.10 (95% CI 1.03–1.16), respectively.
Conclusion
For those at high risk of fatty liver in early adolescence, high omega-6 fatty acid intake and a high ratio of omega-6 to omega-3 fatty acids are associated with increased risk of fatty liver. There should be caution in assuming these associations are causal due to possible undetected and underestimated confounding factors.
Original language | English |
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Pages (from-to) | 3987-4000 |
Number of pages | 14 |
Journal | European Journal of Nutrition |
Volume | 61 |
Issue number | 8 |
Early online date | Jul 2022 |
DOIs | |
Publication status | Published - Dec 2022 |
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Dive into the research topics of 'Prospective dietary polyunsaturated fatty acid intake is associated with trajectories of fatty liver disease: an 8-year follow-up study from adolescence to young adulthood'. Together they form a unique fingerprint.Projects
- 6 Finished
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Nutritional determinants of Cardiometabolic risk & mental health disorders from infancy to adulthood
Oddy, W. (Investigator 01), Mori, T. (Investigator 02), Adams, L. (Investigator 03) & Byrne, S. (Investigator 04)
NHMRC National Health and Medical Research Council
1/01/12 → 31/12/14
Project: Research
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Genes for juvenile-onset myopia
Mackey, D. (Investigator 01), Pennell, C. (Investigator 02), Hewitt, A. (Investigator 03), Young, T. (Investigator 04), Hammond, C. (Investigator 05), Coroneo, M. (Investigator 06) & MacGregor, S. (Investigator 07)
NHMRC National Health and Medical Research Council
1/01/12 → 31/12/14
Project: Research
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Childhood Obesity & its Relationship to Adult Sleep Disordered Breathing
Eastwood, P. (Investigator 01), Hillman, D. (Investigator 02), Smith, A. (Investigator 03), McArdle, N. (Investigator 04) & Huang, R.-C. (Investigator 05)
NHMRC National Health and Medical Research Council
1/01/12 → 31/12/14
Project: Research