Prospective Assessment of Rhinovirus Symptoms and Species Recurrence in Children with and Without an Acute Wheezing Exacerbation

Robert Lethbridge, Franciska Prastanti, Cassandra Robertson, Stephen Oo, Siew Kim Khoo, Peter N. Le Souëf, Ingrid A. Laing

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

To assess if the difference in species-specific immune response to RV-C correlates with a higher frequency of reinfection, shorter time to reinfection, or different symptom severity than infections with RV-A or RV-B. Forty-Three patients were enrolled of which 34 were successfully tracked longitudinally over 3 months, with nasal swabs and symptom questionnaires provided every 2 weeks to identify rhinovirus (RV) strains and the concurrent symptomatology. No difference was found in the time to reinfection with an RV species between RV-C and RV-A or RV-B (p = 0.866). There was a trend toward more rapid reinfection with the same species in RV-C than RV-A (55.1 days vs. 67.9 days), but this failed to reach statistical significance (p = 0.105). RV infections were generally associated with only minor symptoms, with rhinorrhea being the only significantly associated symptom (p = 0.01). RV-C was shown to have higher levels of lethargy and wheeze than other RV species. Time to reinfection with subsequent RV is not influenced by the species of the preceding RV.

Original languageEnglish
Pages (from-to)299-305
Number of pages7
JournalViral Immunology
Volume31
Issue number4
DOIs
Publication statusPublished - 1 May 2018

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