Proposed empiric antibiotic therapy for prosthetic joint infections: an analysis of the Prosthetic Joint Infection in Australia and New Zealand, Observational (PIANO) cohort

Joshua S. Davis, Sarah Metcalf, David L. Paterson, James O. Robinson, Benjamin Clarke, Laurens Manning

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Empiric antibiotic therapy in suspected prosthetic joint infection should cover likely pathogens while avoiding overly broad-spectrum antibiotics. We analysed individual patient data from a large prospective cohort study (Prosthetic Joint Infection in Australia and New Zealand, Observational (PIANO)) and found that causative organisms vary with the presentation type, with early post-operative infections more likely to be polymicrobial (41%) compared with late acute infections (10%). We thus propose empirical regimens tailored to the presentation type and presence or absence of sepsis.

Original languageEnglish
Pages (from-to)322-325
Number of pages4
JournalInternal Medicine Journal
Volume52
Issue number2
DOIs
Publication statusPublished - Feb 2022

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