Proportion of undercarboxylated osteocalcin and serum P1NP predict incidence of myocardial infarction in older men

Bu Yeap, H. Alfonso, Paul Chubb, Liz Byrnes, John Beilby, P.R. Ebeling, C.A. Allan, Carl Schultz, Graeme Hankey, J. Golledge, Leon Flicker, Paul Norman

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Abstract

Copyright © 2015 by the Endocrine Society. Context: Undercarboxylated osteocalcin (ucOC) modulates insulin secretion and sensitivity in mice, and higher ucOC is associated with lower prevalence of diabetes in men. The influence of ucOC distinct from other markers of bone turnover on incidence of cardiovascular events is unclear. Participants: Community-dwelling men aged 70-89 years resident in Perth, Western Australia. Main Outcome Measures: Serum total osteocalcin (TOC), N-terminal propeptide of type I collagen (P1NP), and collagen type I C-terminal cross-linked telopeptide (CTX) were measured by immunoassay, and ucOC by hydroxyapatite binding. The ratio ucOC/TOC was calculated. Hospital admissions and deaths from myocardial infarction (MI) and stroke were ascertained. Results: There were 3384 men followed for 7.0 years, during which 293 experienced an MI, 251 stroke, and 2840 neither. In multivariate analyses, higher ratio of ucOC/TOC (expressed as %) was associated with lower incidence of MI (quartiles Q2-4, 49% versus Q1,49%, hazard ratio 0.70, 95% confidence interval <0.54-0.91), but not of stroke (0.99, 0.73-1.34). Higher P1NP was associated with higher incidence of MI (Q2-4,28.2
Original languageEnglish
Pages (from-to)3934-3942
Number of pages9
JournalJournal of Clinical Endocrinology and Metabolism
Volume100
Issue number10
Early online date26 Aug 2015
DOIs
Publication statusPublished - Oct 2015

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