Progressive ventilation inhomogeneity in infants with cystic fibrosis after pulmonary infection

Shannon Simpson; S. Ranganathan; J. Park; L. Turkovic; R.M. Robins-Browne; B. Skoric; Kathryn Ramsey; T. Rosenow; G.L. Banton; L. Berry; Stephen Stick; Graham Hall

doi:10.1183/13993003.00622-2015

Progressive ventilation inhomogeneity in infants with cystic fibrosis after pulmonary infection

Shannon Simpson, S. Ranganathan, J. Park, L. Turkovic, R.M. Robins-Browne, B. Skoric, Kathryn Ramsey, T. Rosenow, G.L. Banton, L. Berry, Stephen Stick, Graham Hall

UWA Centre for Child Health Research (affiliated with the Telethon Kids Institute)

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

Copyright © ERS 2015. Measures of ventilation distribution are promising for monitoring early lung disease in cystic fibrosis (CF). This study describes the cross-sectional and longitudinal impacts of pulmonary inflammation and infection on ventilation homogeneity in infants with CF. Infants diagnosed with CF underwent multiple breath washout (MBW) testing and bronchoalveolar lavage at three time points during the first 2 years of life. Measures were obtained for 108 infants on 156 occasions. Infants with a significant pulmonary infection at the time of MBW showed increases in lung clearance index (LCI) of 0.400 units (95% CI 0.150-0.648; p=0.002). The impact was long lasting, with previous pulmonary infection leading to increased ventilation inhomogeneity over time compared to those who remained free of infection ( p

Original language	English
Pages (from-to)	1680-1690
Journal	European Respiratory Journal
Volume	46
Issue number	6
Early online date	17 Sep 2015
DOIs	https://doi.org/10.1183/13993003.00622-2015
Publication status	Published - Dec 2015

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10.1183/13993003.00622-2015

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title = "Progressive ventilation inhomogeneity in infants with cystic fibrosis after pulmonary infection",

abstract = "Copyright {\textcopyright} ERS 2015. Measures of ventilation distribution are promising for monitoring early lung disease in cystic fibrosis (CF). This study describes the cross-sectional and longitudinal impacts of pulmonary inflammation and infection on ventilation homogeneity in infants with CF. Infants diagnosed with CF underwent multiple breath washout (MBW) testing and bronchoalveolar lavage at three time points during the first 2 years of life. Measures were obtained for 108 infants on 156 occasions. Infants with a significant pulmonary infection at the time of MBW showed increases in lung clearance index (LCI) of 0.400 units (95% CI 0.150-0.648; p=0.002). The impact was long lasting, with previous pulmonary infection leading to increased ventilation inhomogeneity over time compared to those who remained free of infection ( p",

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Progressive ventilation inhomogeneity in infants with cystic fibrosis after pulmonary infection. / Simpson, Shannon; Ranganathan, S.; Park, J.; Turkovic, L.; Robins-Browne, R.M.; Skoric, B.; Ramsey, Kathryn ; Rosenow, T.; Banton, G.L.; Berry, L.; Stick, Stephen; Hall, Graham.

In: European Respiratory Journal, Vol. 46, No. 6, 12.2015, p. 1680-1690.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Progressive ventilation inhomogeneity in infants with cystic fibrosis after pulmonary infection

AU - Simpson, Shannon

AU - Ranganathan, S.

AU - Park, J.

AU - Turkovic, L.

AU - Robins-Browne, R.M.

AU - Skoric, B.

AU - Ramsey, Kathryn

AU - Rosenow, T.

AU - Banton, G.L.

AU - Berry, L.

AU - Stick, Stephen

AU - Hall, Graham

PY - 2015/12

Y1 - 2015/12

N2 - Copyright © ERS 2015. Measures of ventilation distribution are promising for monitoring early lung disease in cystic fibrosis (CF). This study describes the cross-sectional and longitudinal impacts of pulmonary inflammation and infection on ventilation homogeneity in infants with CF. Infants diagnosed with CF underwent multiple breath washout (MBW) testing and bronchoalveolar lavage at three time points during the first 2 years of life. Measures were obtained for 108 infants on 156 occasions. Infants with a significant pulmonary infection at the time of MBW showed increases in lung clearance index (LCI) of 0.400 units (95% CI 0.150-0.648; p=0.002). The impact was long lasting, with previous pulmonary infection leading to increased ventilation inhomogeneity over time compared to those who remained free of infection ( p

AB - Copyright © ERS 2015. Measures of ventilation distribution are promising for monitoring early lung disease in cystic fibrosis (CF). This study describes the cross-sectional and longitudinal impacts of pulmonary inflammation and infection on ventilation homogeneity in infants with CF. Infants diagnosed with CF underwent multiple breath washout (MBW) testing and bronchoalveolar lavage at three time points during the first 2 years of life. Measures were obtained for 108 infants on 156 occasions. Infants with a significant pulmonary infection at the time of MBW showed increases in lung clearance index (LCI) of 0.400 units (95% CI 0.150-0.648; p=0.002). The impact was long lasting, with previous pulmonary infection leading to increased ventilation inhomogeneity over time compared to those who remained free of infection ( p

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DO - 10.1183/13993003.00622-2015

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EP - 1690

JO - The European Respiratory Journal

JF - The European Respiratory Journal

SN - 0903-1936

IS - 6

ER -

Progressive ventilation inhomogeneity in infants with cystic fibrosis after pulmonary infection

Abstract

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