Progressive ventilation inhomogeneity in infants with cystic fibrosis after pulmonary infection

Shannon Simpson, S. Ranganathan, J. Park, L. Turkovic, R.M. Robins-Browne, B. Skoric, Kathryn Ramsey, T. Rosenow, G.L. Banton, L. Berry, Stephen Stick, Graham Hall

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)


Copyright © ERS 2015. Measures of ventilation distribution are promising for monitoring early lung disease in cystic fibrosis (CF). This study describes the cross-sectional and longitudinal impacts of pulmonary inflammation and infection on ventilation homogeneity in infants with CF. Infants diagnosed with CF underwent multiple breath washout (MBW) testing and bronchoalveolar lavage at three time points during the first 2 years of life. Measures were obtained for 108 infants on 156 occasions. Infants with a significant pulmonary infection at the time of MBW showed increases in lung clearance index (LCI) of 0.400 units (95% CI 0.150-0.648; p=0.002). The impact was long lasting, with previous pulmonary infection leading to increased ventilation inhomogeneity over time compared to those who remained free of infection ( p
Original languageEnglish
Pages (from-to)1680-1690
JournalEuropean Respiratory Journal
Issue number6
Early online date17 Sep 2015
Publication statusPublished - Dec 2015


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