Progressive impairment of testicular endocrine function in ageing men: Testosterone and dihydrotestosterone decrease, and luteinizing hormone increases, in men transitioning from the 8th to 9th decades of life

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Abstract

CONTEXT: Sex hormone trajectories in ageing men and their health implications remain unclear. We examined longitudinal trajectories and associations of testosterone (T), dihydrotestosterone (DHT), oestradiol (E2), luteinizing hormone (LH) and sex hormone-binding globulin (SHBG) in oldest old men.

DESIGN: Prospective cohort study.

PARTICIPANTS: We studied 1025 community-dwelling men median age 75.1 years at baseline with 8.6 years of follow-up.

MEASUREMENTS: Baseline and follow-up T, DHT and E2 were assayed using mass spectrometry. Physical performance was assessed at follow-up. Correlations and covariate-adjusted P-values were determined.

RESULTS: Longitudinal change in T was -2.0%/year, DHT -7.2%/year, LH +7.5%/year, SHBG +5.6%/year while E2 remained stable. Annualized increases in LH correlated with decreases in T and DHT (r = -.20, P < .0001 and r = -.12, P = .0035, respectively). Higher baseline T correlated with better physical performance at follow-up (eg, Step test r = .07, P = .03), as did higher baseline DHT (eg, time to sit-stand [TSS] r = -.07, P = .01). Larger annualized increases in LH predicted poorer physical performance at follow-up (eg, TSS r = .14, P = .001). Higher T at follow-up was associated with better physical performance (eg, TSS r = -.07, P = .04), as were higher DHT and lower LH. At baseline, 24 men (2.4%) had abnormally high LH (>16 IU/L); at follow-up, 175 (17.4%) had high LH of whom 70 had low T (<6.4 nmol/L).

CONCLUSIONS: Annualized increases in LH are associated with declines in T and DHT, and predict poorer subsequent physical performance in oldest old men. Men transitioning from 8th to 9th decades exhibit biochemical evidence of progressively impaired testicular endocrine function, warranting further evaluation.

Original languageEnglish
Pages (from-to)88–95
JournalClinical Endocrinology
Volume88
Issue number1
DOIs
Publication statusPublished - 2018

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Dihydrotestosterone
Luteinizing Hormone
Testosterone
Sex Hormone-Binding Globulin
Independent Living
Men's Health
Gonadal Steroid Hormones
Estradiol
Mass Spectrometry
Cohort Studies
Prospective Studies

Cite this

@article{411875855469467e9ecd7a3d95b0b24f,
title = "Progressive impairment of testicular endocrine function in ageing men: Testosterone and dihydrotestosterone decrease, and luteinizing hormone increases, in men transitioning from the 8th to 9th decades of life",
abstract = "CONTEXT: Sex hormone trajectories in ageing men and their health implications remain unclear. We examined longitudinal trajectories and associations of testosterone (T), dihydrotestosterone (DHT), oestradiol (E2), luteinizing hormone (LH) and sex hormone-binding globulin (SHBG) in oldest old men.DESIGN: Prospective cohort study.PARTICIPANTS: We studied 1025 community-dwelling men median age 75.1 years at baseline with 8.6 years of follow-up.MEASUREMENTS: Baseline and follow-up T, DHT and E2 were assayed using mass spectrometry. Physical performance was assessed at follow-up. Correlations and covariate-adjusted P-values were determined.RESULTS: Longitudinal change in T was -2.0{\%}/year, DHT -7.2{\%}/year, LH +7.5{\%}/year, SHBG +5.6{\%}/year while E2 remained stable. Annualized increases in LH correlated with decreases in T and DHT (r = -.20, P < .0001 and r = -.12, P = .0035, respectively). Higher baseline T correlated with better physical performance at follow-up (eg, Step test r = .07, P = .03), as did higher baseline DHT (eg, time to sit-stand [TSS] r = -.07, P = .01). Larger annualized increases in LH predicted poorer physical performance at follow-up (eg, TSS r = .14, P = .001). Higher T at follow-up was associated with better physical performance (eg, TSS r = -.07, P = .04), as were higher DHT and lower LH. At baseline, 24 men (2.4{\%}) had abnormally high LH (>16 IU/L); at follow-up, 175 (17.4{\%}) had high LH of whom 70 had low T (<6.4 nmol/L).CONCLUSIONS: Annualized increases in LH are associated with declines in T and DHT, and predict poorer subsequent physical performance in oldest old men. Men transitioning from 8th to 9th decades exhibit biochemical evidence of progressively impaired testicular endocrine function, warranting further evaluation.",
keywords = "Journal Article",
author = "Yeap, {Bu B} and Laurens Manning and Chubb, {S A Paul} and Handelsman, {David J} and Almeida, {Osvaldo P} and Hankey, {Graeme J.} and Leon Flicker",
note = "{\circledC} 2017 John Wiley & Sons Ltd.",
year = "2018",
doi = "10.1111/cen.13484",
language = "English",
volume = "88",
pages = "88–95",
journal = "Clinical Endocrinology",
issn = "0300-0664",
publisher = "John Wiley & Sons",
number = "1",

}

TY - JOUR

T1 - Progressive impairment of testicular endocrine function in ageing men

T2 - Testosterone and dihydrotestosterone decrease, and luteinizing hormone increases, in men transitioning from the 8th to 9th decades of life

AU - Yeap, Bu B

AU - Manning, Laurens

AU - Chubb, S A Paul

AU - Handelsman, David J

AU - Almeida, Osvaldo P

AU - Hankey, Graeme J.

AU - Flicker, Leon

N1 - © 2017 John Wiley & Sons Ltd.

PY - 2018

Y1 - 2018

N2 - CONTEXT: Sex hormone trajectories in ageing men and their health implications remain unclear. We examined longitudinal trajectories and associations of testosterone (T), dihydrotestosterone (DHT), oestradiol (E2), luteinizing hormone (LH) and sex hormone-binding globulin (SHBG) in oldest old men.DESIGN: Prospective cohort study.PARTICIPANTS: We studied 1025 community-dwelling men median age 75.1 years at baseline with 8.6 years of follow-up.MEASUREMENTS: Baseline and follow-up T, DHT and E2 were assayed using mass spectrometry. Physical performance was assessed at follow-up. Correlations and covariate-adjusted P-values were determined.RESULTS: Longitudinal change in T was -2.0%/year, DHT -7.2%/year, LH +7.5%/year, SHBG +5.6%/year while E2 remained stable. Annualized increases in LH correlated with decreases in T and DHT (r = -.20, P < .0001 and r = -.12, P = .0035, respectively). Higher baseline T correlated with better physical performance at follow-up (eg, Step test r = .07, P = .03), as did higher baseline DHT (eg, time to sit-stand [TSS] r = -.07, P = .01). Larger annualized increases in LH predicted poorer physical performance at follow-up (eg, TSS r = .14, P = .001). Higher T at follow-up was associated with better physical performance (eg, TSS r = -.07, P = .04), as were higher DHT and lower LH. At baseline, 24 men (2.4%) had abnormally high LH (>16 IU/L); at follow-up, 175 (17.4%) had high LH of whom 70 had low T (<6.4 nmol/L).CONCLUSIONS: Annualized increases in LH are associated with declines in T and DHT, and predict poorer subsequent physical performance in oldest old men. Men transitioning from 8th to 9th decades exhibit biochemical evidence of progressively impaired testicular endocrine function, warranting further evaluation.

AB - CONTEXT: Sex hormone trajectories in ageing men and their health implications remain unclear. We examined longitudinal trajectories and associations of testosterone (T), dihydrotestosterone (DHT), oestradiol (E2), luteinizing hormone (LH) and sex hormone-binding globulin (SHBG) in oldest old men.DESIGN: Prospective cohort study.PARTICIPANTS: We studied 1025 community-dwelling men median age 75.1 years at baseline with 8.6 years of follow-up.MEASUREMENTS: Baseline and follow-up T, DHT and E2 were assayed using mass spectrometry. Physical performance was assessed at follow-up. Correlations and covariate-adjusted P-values were determined.RESULTS: Longitudinal change in T was -2.0%/year, DHT -7.2%/year, LH +7.5%/year, SHBG +5.6%/year while E2 remained stable. Annualized increases in LH correlated with decreases in T and DHT (r = -.20, P < .0001 and r = -.12, P = .0035, respectively). Higher baseline T correlated with better physical performance at follow-up (eg, Step test r = .07, P = .03), as did higher baseline DHT (eg, time to sit-stand [TSS] r = -.07, P = .01). Larger annualized increases in LH predicted poorer physical performance at follow-up (eg, TSS r = .14, P = .001). Higher T at follow-up was associated with better physical performance (eg, TSS r = -.07, P = .04), as were higher DHT and lower LH. At baseline, 24 men (2.4%) had abnormally high LH (>16 IU/L); at follow-up, 175 (17.4%) had high LH of whom 70 had low T (<6.4 nmol/L).CONCLUSIONS: Annualized increases in LH are associated with declines in T and DHT, and predict poorer subsequent physical performance in oldest old men. Men transitioning from 8th to 9th decades exhibit biochemical evidence of progressively impaired testicular endocrine function, warranting further evaluation.

KW - Journal Article

U2 - 10.1111/cen.13484

DO - 10.1111/cen.13484

M3 - Article

VL - 88

SP - 88

EP - 95

JO - Clinical Endocrinology

JF - Clinical Endocrinology

SN - 0300-0664

IS - 1

ER -