Prognostic value of a plasma protein-based biomarker test for chronic kidney disease complicating diabetes in Aboriginal Australians

Timothy M E Davis; Kirsten E Peters; Scott Bringans; Daniel McAullay; Arvind Singh; Richard J Lipscombe; Wendy A Davis

doi:10.1111/imj.70275

Prognostic value of a plasma protein-based biomarker test for chronic kidney disease complicating diabetes in Aboriginal Australians

Timothy M E Davis
, Kirsten E Peters
, Scott Bringans
, Daniel McAullay
, Arvind Singh
, Richard J Lipscombe
, Wendy A Davis

Internal Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

The predictive value of PromarkerD tests for incident diabetic kidney disease or rapid decline in estimated glomerular filtration rate was evaluated in 1010 non-Aboriginal and 71 Aboriginal adults with diabetes. Areas under the receiver operating characteristic curves were not significantly different (P ≥ 0.081) for first- (non-Aboriginals 0.890 (95% confidence interval 0.864 to 0.915) and Aboriginals 0.769 (0.624 to 0.915)) and second-generation (0.890 (0.862 to 0.917) and 0.711 (0.543 to 0.878)) tests. PromarkerD has potential renal prognostic value in Aboriginals with diabetes.

Original language	English
Pages (from-to)	295-299
Number of pages	5
Journal	Internal Medicine Journal
Volume	56
Issue number	2
DOIs	https://doi.org/10.1111/imj.70275
Publication status	Published - Feb 2026

Funding

Funders	Funder number
MRFF Medical Research Future Fund	1154192
NHMRC National Health and Medical Research Council	513781, 1042231

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1111/imj.70275

MRFF - Community-based studies of diabetes and infectious diseases
Davis, T. (Investigator 01)
NHMRC National Health and Medical Research Council
1/01/19 → 31/12/23
Project: Research
The Fremantle Diabetes Study Phase II - A Community Based Study of Diabetes Care Control Complications and Cost
Davis, T. (Chief Investigator), Bruce, D. (Chief Investigator), Davis, W. (Chief Investigator), Davis, E. (Chief Investigator), Geelhoed, E. (Chief Investigator) & Knuiman, M. (Chief Investigator)
NHMRC Project Grants
1/01/08 → 31/12/12
Project: Research

Cite this

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title = "Prognostic value of a plasma protein-based biomarker test for chronic kidney disease complicating diabetes in Aboriginal Australians",

abstract = "The predictive value of PromarkerD tests for incident diabetic kidney disease or rapid decline in estimated glomerular filtration rate was evaluated in 1010 non-Aboriginal and 71 Aboriginal adults with diabetes. Areas under the receiver operating characteristic curves were not significantly different (P ≥ 0.081) for first- (non-Aboriginals 0.890 (95\% confidence interval 0.864 to 0.915) and Aboriginals 0.769 (0.624 to 0.915)) and second-generation (0.890 (0.862 to 0.917) and 0.711 (0.543 to 0.878)) tests. PromarkerD has potential renal prognostic value in Aboriginals with diabetes.",

keywords = "Humans, Biomarkers/blood, Male, Female, Middle Aged, Prognosis, Renal Insufficiency, Chronic/blood, Australia/epidemiology, Adult, Aged, Diabetic Nephropathies/blood, Glomerular Filtration Rate/physiology, Blood Proteins/metabolism, Predictive Value of Tests",

author = "Davis, \{Timothy M E\} and Peters, \{Kirsten E\} and Scott Bringans and Daniel McAullay and Arvind Singh and Lipscombe, \{Richard J\} and Davis, \{Wendy A\}",

note = "{\textcopyright} 2025 Royal Australasian College of Physicians.",

year = "2026",

month = feb,

doi = "10.1111/imj.70275",

language = "English",

volume = "56",

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AU - Davis, Timothy M E

AU - Peters, Kirsten E

AU - Bringans, Scott

AU - McAullay, Daniel

AU - Singh, Arvind

AU - Lipscombe, Richard J

AU - Davis, Wendy A

PY - 2026/2

Y1 - 2026/2

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AB - The predictive value of PromarkerD tests for incident diabetic kidney disease or rapid decline in estimated glomerular filtration rate was evaluated in 1010 non-Aboriginal and 71 Aboriginal adults with diabetes. Areas under the receiver operating characteristic curves were not significantly different (P ≥ 0.081) for first- (non-Aboriginals 0.890 (95% confidence interval 0.864 to 0.915) and Aboriginals 0.769 (0.624 to 0.915)) and second-generation (0.890 (0.862 to 0.917) and 0.711 (0.543 to 0.878)) tests. PromarkerD has potential renal prognostic value in Aboriginals with diabetes.

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KW - Biomarkers/blood

KW - Male

KW - Female

KW - Middle Aged

KW - Prognosis

KW - Renal Insufficiency, Chronic/blood

KW - Australia/epidemiology

KW - Adult

KW - Aged

KW - Diabetic Nephropathies/blood

KW - Glomerular Filtration Rate/physiology

KW - Blood Proteins/metabolism

KW - Predictive Value of Tests

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JO - Internal Medicine Journal

JF - Internal Medicine Journal

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ER -

Prognostic value of a plasma protein-based biomarker test for chronic kidney disease complicating diabetes in Aboriginal Australians

Abstract

Funding

UN SDGs

Access to Document

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Projects

MRFF - Community-based studies of diabetes and infectious diseases

The Fremantle Diabetes Study Phase II - A Community Based Study of Diabetes Care Control Complications and Cost

Cite this